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Clinical Evaluation of the Effect of Mephenesin on Anxiety

Published online by Cambridge University Press:  08 February 2018

John A. Ewing  and
John H. Mendenhall
John H. Mendenhall
Affiliation:
State Hospital at Butner, North Carolina, U.S.A.
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Extract

The drug which is now known officially as Mephenesin (“Myanesin,” “Tolserol”) was introduced by Berger and Bradley (1946), who showed that it antagonizes strychnine convulsions, counteracts pre-narcotic excitement, and increases the duration of barbiturate anaesthesia. Small doses depress the reflex excitability of the spinal cord, and larger doses have an ascending depressant action on the central nervous system. When Berger (1947) found that doses with little effect on voluntary power restored deranged reciprocal innervation to normal, he suggested that mephenesin might be useful in spastic and hypertonic conditions.

Type
Part I.—Original Articles
Information
Journal of Mental Science , Volume 99 , Issue 416 , July 1953 , pp. 464 - 472
Copyright
Copyright © Royal College of Psychiatrists, 1953 

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