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Synthesis of a novel bioactive glass using the ultrasonic energy assisted hydrothermal method and their biocompatibility evaluation

Published online by Cambridge University Press:  28 August 2014

Swapan Kumar Sarkar ,
Alexander Sadiasa  and
Byong Taek Lee
Swapan Kumar Sarkar
Affiliation:
Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University, Chungnam 330090, Korea
Alexander Sadiasa
Affiliation:
Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University, Chungnam 330090, Korea
Byong Taek Lee*
Affiliation:
Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University, Chungnam 330090, Korea
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

In this study, bioactive glass powders were synthesized via an inexpensive hydrothermal chemical route by the use of ultrasonic energy irradiation. Soda lime, calcium nitrate tetrahydrate, and diammonium hydrogen phosphate were used as the precursor materials to synthesize low-sodium bioactive glass materials based on the conventional 45S5 Bioglass®. The morphological properties of the synthesized powders and the microwave-sintered dense compact were investigated. The mechanical properties of the fabricated dense bioactive glasses were characterized and were found to be very good. The ability to form biological apatite under physiological conditions was demonstrated with simulated body fluid (SBF). The material was shown to be highly biocompatible using the 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide (MTT) assay with osteoblast-like MG63 cells. The cell adhesion and proliferation behavior of osteoblast-like MG63 cells were investigated and found to be excellent.

Type
Articles
Information
Journal of Materials Research , Volume 29 , Issue 16 , 28 August 2014 , pp. 1781 - 1789
Copyright
Copyright © Materials Research Society 2014 

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References

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