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Review: Micro- and nanostructured surface engineering for biomedical applications

Published online by Cambridge University Press:  28 December 2012

Emma Luong-Van ,
Isabel Rodriguez ,
Hong Yee Low ,
Noha Elmouelhi ,
Bruce Lowenhaupt ,
Sriram Natarajan ,
Chee Tiong Lim ,
Rita Prajapati ,
Murty Vyakarnam  and
Kevin Cooper
Emma Luong-Van*
Affiliation:
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Research Link, Singapore 117602
Isabel Rodriguez
Affiliation:
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Research Link, Singapore 117602
Hong Yee Low
Affiliation:
Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Research Link, Singapore 117602
Noha Elmouelhi
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Bruce Lowenhaupt
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Sriram Natarajan
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Chee Tiong Lim
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Rita Prajapati
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Murty Vyakarnam
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
Kevin Cooper
Affiliation:
Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey 08876
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

The engineering of well-defined micro- and nanoscaled surface topographies on biomedical metals and polymeric materials has been explored as a strategy to control biological responses. In this review, the ability of surface features engineered by a variety of methods to promote or reduce protein, blood, and bacterial adhesion is discussed independent of surface chemistry. The interaction of proteins with surface topography is fundamentally important and influences the conformation, the types of protein, as well as the overall amount of protein adhesion, which in many instances is increased over the associated increase in surface area. The use of superhydrophobic surface features is discussed as a manner to engineer antifouling surfaces with protein, blood, and bacterial resistance.

Type
Invited Feature Paper
Information
Journal of Materials Research , Volume 28 , Issue 2: Focus Section: Silicon-based Nanoparticles for Biosensing and Biomedical Applications , 28 January 2013 , pp. 165 - 174
Copyright
Copyright © Materials Research Society 2012

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