Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-23T11:18:58.408Z Has data issue: false hasContentIssue false

Investigation of the in vitro corrosion behavior and biocompatibility of niobium (Nb)-reinforced hydroxyapatite (HA) coating on CoCr alloy for medical implants

Published online by Cambridge University Press:  11 April 2019

Balraj Singh
Affiliation:
Department of Mechanical Engineering, Punjabi University, Patiala, Punjab 147002, India
Gurpreet Singh*
Affiliation:
Department of Mechanical Engineering, Punjabi University, Patiala, Punjab 147002, India
Buta Singh Sidhu
Affiliation:
Dean of Planning and Development, MRS Punjab Technical University, Bathinda, Punjab 151001, India
*
a)Address all correspondence to this author. e-mail: [email protected]
Get access

Abstract

In this study, a niobium-reinforced hydroxyapatite (HA-Nb) coating was developed on cobalt–chromium (CoCr) alloy by plasma spraying with three varied levels, i.e., 10, 20, and 30% of weight percent (wt%) of Nb content. The corrosion behavior and biocompatibility of the samples were analyzed through electrochemical corrosion testing and cytotoxicity studies, respectively. The results of corrosion testing revealed that the HA coating increased the corrosion resistance of the CoCr alloy, and with the incremental increase of Nb reinforcement in HA, corrosion resistance was further enhanced. The HA-30Nb coating demonstrated the finest corrosion resistance with the highest Ecorr and lowest Icorr values, which were about one order of magnitude lower in comparison to the bare CoCr alloy. The surface hardness increased and the surface roughness decreased with the increase of Nb content in the coating. Wettability analysis revealed that HA and HA-Nb coatings had a hydrophilic nature. HA-Nb coatings demonstrated a significantly better cell proliferation than the CoCr alloy.

Type
Article
Copyright
Copyright © Materials Research Society 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Likibi, F., Jiang, B., and Li, B.: Biomimetic nanocoating promotes osteoblast cell adhesion on biomedical implants. J. Mater. Res. 23, 3222 (2008).CrossRefGoogle Scholar
Sahasrabudhe, H., Bose, S., and Bandyopadhyay, A.: Laser processed calcium phosphate reinforced CoCrMo for load-bearing applications: Processing and wear induced damage evaluation. Acta Biomater. 66, 118 (2018).CrossRefGoogle ScholarPubMed
Cetiner, D., Paksoy, A.H., Tazegul, O., Baydogan, M., Guleryuz, H., Cimenoglu, H., and Atar, E.: A novel fabrication method for a TiO2 layer over CoCr alloy. Surf. Eng. 35, 234 (2018).CrossRefGoogle Scholar
Pradhan, D., Wren, A.W., Misture, S.T., and Mellott, N.P.: Investigating the structure and biocompatibility of niobium and titanium oxides as coatings for orthopedic metallic implants. Mater. Sci. Eng., C 58, 918 (2016).CrossRefGoogle ScholarPubMed
Luo, L., Petit, A., Antoniou, J., Zukor, D.J., Huk, O.L., Liu, R.C.W., Winnik, F.M., and Mwale, F.: Effect of cobalt and chromium ions on MMP-1, TIMP-1, and TNF-α gene expression in human U937 macrophages: A role for tyrosine kinases. Biomaterials 26, 5587 (2005).CrossRefGoogle ScholarPubMed
Darwiche, H., Barsoum, W.K., Klika, A., Krebs, V.E., and Molloy, R.: Retrospective analysis of infection rate after early reoperation in total hip arthroplasty. Clin. Orthop. Relat. Res. 468, 2392 (2010).CrossRefGoogle ScholarPubMed
Garvin, K.L. and Konigsberg, B.S.: Infection following total knee arthroplasty: Prevention and management. J. Bone Jt. Surg. 93, 1167 (2011).CrossRefGoogle ScholarPubMed
Logan, N., Sherif, A., Cross, A.J., Collins, S.N., Traynor, A., Bozec, L., Parkin, I.P., and Brett, P.: TiO2-coated CoCrMo: Improving the osteogenic differentiation and adhesion of mesenchymal stem cells in vitro. J. Biomed. Mater. Res., Part A 103, 1208 (2015).CrossRefGoogle ScholarPubMed
Singh, B., Singh, G., and Sidhu, B.S.: Analysis of corrosion behavior and surface properties of plasma-sprayed HA/Ta coating on CoCr alloy. J. Therm. Spray Technol. 27, 1401 (2018).CrossRefGoogle Scholar
Ratha, I., Anand, A., Chatterjee, S., Kundu, B., and Kumar, G.S.: Preliminary study on effect of nano-hydroxyapatite and mesoporous bioactive glass on DNA. J. Mater. Res. 33, 1592 (2018).CrossRefGoogle Scholar
Campbell, A.A.: Bioceramics for implant coatings. Mater. Today 6, 26 (2003).CrossRefGoogle Scholar
Moskalewicz, T., Łukaszczyk, A., Kruk, A., Kot, M., Jugowiec, D., Dubiel, B., and Radziszewska, A.: Porous HA and nanocomposite nc-TiO2/HA coatings to improve the electrochemical corrosion resistance of the Co–28Cr–5Mo alloy. Mater. Chem. Phys. 199, 144 (2017).CrossRefGoogle Scholar
ibrahim Coşkun, M., Karahan, İ.H., and Yücel, Y.: Optimized electrodeposition concentrations for hydroxyapatite coatings on CoCrMo biomedical alloys by computational techniques. Electrochim. Acta 150, 46 (2014).CrossRefGoogle Scholar
Shirdar, M.R., Izman, S., Taheri, M.M., Assadian, M., and Abdul Kadir, M.R.: Effect of electrophoretic deposition parameters on the corrosion behavior of hydroxyapatite-coated cobalt–chromium using response surface methodology. Arabian J. Sci. Eng. 41, 591 (2016).CrossRefGoogle Scholar
Kheimehsari, H., Izman, S., and Shirdar, M.R.: Effects of HA-coating on the surface morphology and corrosion behavior of a Co–Cr-based implant in different conditions. J. Mater. Eng. Perform. 24, 2294 (2015).CrossRefGoogle Scholar
Barry, J.N., Cowley, A., McNally, P.J., and Dowling, D.P.: Influence of substrate metal alloy type on the properties of hydroxyapatite coatings deposited using a novel ambient temperature deposition technique. J. Biomed. Mater. Res., Part A 102, 871 (2014).CrossRefGoogle ScholarPubMed
Singh, G., Singh, H., and Sidhu, B.S.: Corrosion behavior of plasma sprayed hydroxyapatite and hydroxyapatite-silicon oxide coatings on AISI 304 for biomedical application. Appl. Surf. Sci. 284, 811 (2013).CrossRefGoogle Scholar
Singh, T.P., Singh, H., and Singh, H.: Characterization, corrosion resistance, and cell response of high-velocity flame-sprayed HA and HA/TiO2 coatings on 316L SS. J. Therm. Spray Technol. 21, 917 (2012).CrossRefGoogle Scholar
Xiong, Y., Hu, X., and Song, R.: Characteristics of CeO2/ZrO2-HA composite coating on ZK60 magnesium alloy. J. Mater. Res. 32, 1073 (2017).CrossRefGoogle Scholar
Singh, G., Singh, H., and Sidhu, B.S.: Characterization and corrosion resistance of plasma sprayed HA and HA–SiO2 coatings on Ti–6Al–4V. Surf. Coat. Technol. 228, 242 (2013).CrossRefGoogle Scholar
Huang, Y., Zhang, X., Qiao, H., Hao, M., Zhang, H., Xu, Z., Zhang, X., Pang, X., and Lin, H.: Corrosion resistance and cytocompatibility studies of zinc-doped fluorohydroxyapatite nanocomposite coatings on titanium implant. Ceram. Int. 42, 1903 (2016).CrossRefGoogle Scholar
Anusha Thampi, V.V. and Subramanian, B.: Enhancement of bioactivity of pulsed magnetron sputtered TiCxNy with bioactive glass (BAG) incorporated polycaprolactone (PCL) composite scaffold. J. Alloys Compd. 649, 1210 (2015).CrossRefGoogle Scholar
Singh, G., Singh, H., and Sidhu, B.S.: In vitro corrosion investigations of plasma-sprayed hydroxyapatite and hydroxyapatite-calcium phosphate coatings on 316L SS. Bull. Mater. Sci. 37, 1519 (2014).CrossRefGoogle Scholar
Ke, D., Robertson, S., Dernell, W., Bandyopadhyay, A., and Bose, S.: Effects of MgO and SiO2 on plasma-sprayed hydroxyapatite coating: An in vivo study in rat distal femoral defects. ACS Appl. Mater. Interfaces 9, 25731 (2017).CrossRefGoogle Scholar
Fielding, G., Roy, M., Bandyopadhyay, A., and Bose, S.: Antibacterial and biological characteristics of silver containing and strontium doped plasma sprayed hydroxyapatite coatings. Acta Biomater. 8, 144 (2012).CrossRefGoogle ScholarPubMed
Pauline, S.A. and Rajendran, N.: Effect of Sr on the bioactivity and corrosion resistance of nanoporous niobium oxide coating for orthopaedic applications. Mater. Sci. Eng., C 36, 194 (2014).CrossRefGoogle ScholarPubMed
Sowa, M., Kazek-Kęsik, A., Krząkała, A., Socha, R.P., Dercz, G., Michalska, J., and Simka, W.: Modification of niobium surfaces using plasma electrolytic oxidation in silicate solutions. J. Solid State Electrochem. 18, 3129 (2014).CrossRefGoogle Scholar
Robin, A. and Rosa, J.L.: Corrosion behavior of niobium, tantalum and their alloys in hot hydrochloric and phosphoric acid solutions. Int. J. Refract. Met. Hard Mater. 18, 13 (2000).CrossRefGoogle Scholar
Fathi, M.H. and Azam, F.: Novel hydroxyapatite/tantalum surface coating for metallic dental implant. Mater. Lett. 61, 1238 (2007).CrossRefGoogle Scholar
Sun, L., Berndt, C.C., Gross, K.A., and Kucuk, A.: Material fundamentals and clinical performance of plasma-sprayed hydroxyapatite coatings: A review. J. Biomed. Mater. Res. 58, 570 (2001).CrossRefGoogle ScholarPubMed
Sun, L., Berndt, C.C., and Grey, C.P.: Phase, structural and microstructural investigations of plasma sprayed hydroxyapatite coatings. Mater. Sci. Eng., A 360, 70 (2003).CrossRefGoogle Scholar
Singh, G., Singh, S., and Prakash, S.: Surface characterization of plasma sprayed pure and reinforced hydroxyapatite coating on Ti6Al4V alloy. Surf. Coat. Technol. 205, 4814 (2011).CrossRefGoogle Scholar
Ntsoane, T.P., Topic, M., and Bucher, R.: Near-surface in vitro studies of plasma sprayed hydroxyapatite coatings. Powder Diffr. 26, 138 (2011).CrossRefGoogle Scholar
Ardelean, H., Frateur, I., and Marcus, P.: Corrosion protection of magnesium alloys by cerium, zirconium and niobium-based conversion coatings. Corros. Sci. 50, 1907 (2008).CrossRefGoogle Scholar
Nagarajan, S., Raman, V., and Rajendran, N.: Synthesis and electrochemical characterization of porous niobium oxide coated 316L SS for orthopedic applications. Mater. Chem. Phys. 119, 363 (2010).CrossRefGoogle Scholar
Pauline, S.A. and Rajendran, N.: Biomimetic novel nanoporous niobium oxide coating for orthopaedic applications. Appl. Surf. Sci. 290, 448 (2014).CrossRefGoogle Scholar
Prevéy, P.S.: X-ray diffraction characterization of crystallinity and phase composition in plasma-sprayed hydroxyapatite coatings. J. Therm. Spray Technol. 9, 369 (2000).CrossRefGoogle Scholar
Zhang, C., Xu, H., Geng, X., Wang, J., Xiao, J., and Zhu, P.: Effect of spray distance on microstructure and tribological performance of suspension plasma-sprayed hydroxyapatite–titania composite coatings. J. Therm. Spray Technol. 25, 1255 (2016).CrossRefGoogle Scholar
Williams, R.K., Butler, W.H., Graves, R.S., and Moore, J.P.: Experimental and theoretical evaluation of the phonon thermal conductivity of niobium at intermediate temperatures. Phys. Rev. B 28, 6316 (1983).CrossRefGoogle Scholar
Rapacz-Kmita, A., Ślósarczyk, A., Paszkiewicz, Z., and Paluch, D.: Evaluation of HAp–ZrO2 composites and monophase HAp bioceramics. In vitro study. J. Mater. Sci. 39, 5865 (2004).CrossRefGoogle Scholar
Chen, X., Zhang, B., Gong, Y., Zhou, P., and Li, H.: Mechanical properties of nanodiamond-reinforced hydroxyapatite composite coatings deposited by suspension plasma spraying. Appl. Surf. Sci. 439, 60 (2018).CrossRefGoogle Scholar
Ellies, L.G., Nelson, D.G.A., and Featherstone, J.D.B.: Crystallographic changes in calcium phosphates during plasma-spraying. Biomaterials 13, 313 (1992).CrossRefGoogle ScholarPubMed
Hasan, M.F., Wang, J., and Berndt, C.: Determination of the mechanical properties of plasma-sprayed hydroxyapatite coatings using the knoop indentation technique. J. Therm. Spray Technol. 24, 865 (2015).CrossRefGoogle Scholar
Gopi, D., Karthika, A., Rajeswari, D., Kavitha, L., Pramod, R., and Dwivedi, J.: Investigation on corrosion protection and mechanical performance of minerals substituted hydroxyapatite coating on HELCDEB-treated titanium using pulsed electrodeposition method. RSC Adv. 4, 34751 (2014).CrossRefGoogle Scholar
Hasan, M.F., Wang, J., and Berndt, C.: Evaluation of the mechanical properties of plasma sprayed hydroxyapatite coatings. Appl. Surf. Sci. 303, 155 (2014).CrossRefGoogle Scholar
Yamashita, D., Machigashira, M., Miyamoto, M., Takeuchi, H., Noguchi, K., Izumi, Y., and Ban, S.: Effect of surface roughness on initial responses of osteoblast-like cells on two types of zirconia. Dent. Mater. J. 28, 461 (2009).CrossRefGoogle ScholarPubMed
Shah, F.A., Johansson, M.L., Omar, O., Simonsson, H., Palmquist, A., and Thomsen, P.: Laser-modified surface enhances osseointegration and biomechanical anchorage of commercially pure titanium implants for bone-anchored hearing systems. PLoS One 11, e0157504 (2016).CrossRefGoogle ScholarPubMed
Gross, K.A. and Babovic, M.: Influence of abrasion on the surface characteristics of thermally sprayed hydroxyapatite coatings. Biomaterials 23, 4731 (2002).CrossRefGoogle ScholarPubMed
Xie, W., Wang, J., Berndt, C., Xie, W., Wang, J., and Berndt, C.C.: Ethylene methacrylic acid (EMAA) single splat morphology. Coatings 3, 82 (2013).CrossRefGoogle Scholar
Geng, Z., Wang, R., Zhuo, X., Li, Z., Huang, Y., Ma, L., Cui, Z., Zhu, S., Liang, Y., Liu, Y., Bao, H., Li, X., Huo, Q., Liu, Z., and Yang, X.: Incorporation of silver and strontium in hydroxyapatite coating on titanium surface for enhanced antibacterial and biological properties. Mater. Sci. Eng., C 71, 852 (2017).CrossRefGoogle ScholarPubMed
Marashi-Najafi, F., Khalil-Allafi, J., and Etminanfar, M.R.: Biocompatibility of hydroxyapatite coatings deposited by pulse electrodeposition technique on the Nitinol superelastic alloy. Mater. Sci. Eng., C 76, 278 (2017).CrossRefGoogle ScholarPubMed
Durdu, S., Korkmaz, K., Aktuğ, S.L., and Çakır, A.: Characterization and bioactivity of hydroxyapatite-based coatings formed on steel by electro-spark deposition and micro-arc oxidation. Surf. Coat. Technol. 326, 111 (2017).CrossRefGoogle Scholar
Poorraeisi, M. and Afshar, A.: The study of electrodeposition of hydroxyapatite-ZrO2–TiO2 nanocomposite coatings on 316 stainless steel. Surf. Coat. Technol. 339, 199 (2018).CrossRefGoogle Scholar
Wang, H., Zheng, Y., Jiang, C., Li, Y., and Fu, Y.: In vitro corrosion behavior and cytocompatibility of pure Fe implanted with Ta. Surf. Coat. Technol. 320, 201 (2017).CrossRefGoogle Scholar
Kiahosseini, S.R., Afshar, A., Mojtahedzadeh Larijani, M., and Yousefpour, M.: Structural and corrosion characterization of hydroxyapatite/zirconium nitride-coated AZ91 magnesium alloy by ion beam sputtering. Appl. Surf. Sci. 401, 172 (2017).CrossRefGoogle Scholar
Enayati, M.H., Fathi, M.H., and Zomorodian, A.: Characterisation and corrosion properties of novel hydroxyapatite niobium plasma sprayed coating. Surf. Eng. 25, 338 (2009).CrossRefGoogle Scholar
Mohajernia, S., Pour-Ali, S., Hejazi, S., Saremi, M., and Kiani-Rashid, A-R.: Hydroxyapatite coating containing multi-walled carbon nanotubes on AZ31 magnesium: Mechanical-electrochemical degradation in a physiological environment. Ceram. Int. 44, 8297 (2018).CrossRefGoogle Scholar
Gu, Y.W., Khor, K.A., and Cheang, P.: In vitro studies of plasma-sprayed hydroxyapatite/Ti–6Al–4V composite coatings in simulated body fluid (SBF). Biomaterials 24, 1603 (2003).CrossRefGoogle Scholar
Yang, C.Y., Wang, B.C., Chang, E., and Wu, B.C.: Bond degradation at the plasma-sprayed HA coating/Ti–6Al–4V alloy interface: An in vitro study. J. Mater. Sci.: Mater. Med. 6, 258 (1995).Google Scholar
Zhang, Z., Dunn, M.F., Xiao, T.D., Tomsia, A.P., and Saiz, E.: Nanostructured hydroxyapatite coatings for improved adhesion and corrosion resistance for medical implants. MRS Online Proc. Libr. 703, 291 (2001).CrossRefGoogle Scholar
Balani, K., Anderson, R., Laha, T., Andara, M., Tercero, J., Crumpler, E., and Agarwal, A.: Plasma-sprayed carbon nanotube reinforced hydroxyapatite coatings and their interaction with human osteoblasts in vitro. Biomaterials 28, 618 (2007).CrossRefGoogle ScholarPubMed