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Inductive biomaterials for bone regeneration

Published online by Cambridge University Press:  28 February 2017

Rafid Kasir ,
Varadraj N. Vernekar Open the ORCID record for Varadraj N. Vernekar [Opens in a new window]  and
Cato T. Laurencin
Rafid Kasir
Affiliation:
Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, and Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
Varadraj N. Vernekar
Affiliation:
Institute for Regenerative Engineering, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, and Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA
Cato T. Laurencin*
Affiliation:
Institute for Regenerative Engineering, University of Connecticut Health Center, Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences, and Department of Orthopaedic Surgery, Farmington, CT 06030, USA; Department of Materials Science and Engineering, Department of Chemical and Biomolecular Engineering, and Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USA
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Inductive biomaterials are sought as alternatives to traditional materials used to treat bone defects. Traditional materials include autologous bone grafts that must be obtained surgically, and allografts that carry the risk of disease transmission and infection. Whereas the use of growth factors to stimulate bone growth has seen considerable advances, their efficacy is usually limited to supra-physiological doses with considerable side effects. On the other hand, certain biomaterials have an intrinsic ability to stimulate bone regeneration in lieu of growth factor use, and their use in repairing bone defects as well as improving the osteointegration of implants has been promising. These materials known as osteoinductive biomaterials include ceramics, metals, polymers, and composites of these materials. In this review, we examine the relevant properties of these different materials in their ability to induce bone formation.

Keywords

osteoinductionbone graftbone regeneration
Type
Invited Feature Paper
Information
Journal of Materials Research , Volume 32 , Issue 6 , 28 March 2017 , pp. 1047 - 1060
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

b)

These authors contributed equally to this work.

Contributing Editor: Adrian B. Mann

This paper has been selected as an Invited Feature Paper.

References

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