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Glucomannan asymmetric membranes for wound dressing

Published online by Cambridge University Press:  30 January 2019

Giovana Maria Genevro ,
Reginaldo Jose Gomes Neto ,
Letícia de Almeida Paulo ,
Patrícia Santos Lopes ,
Mariana Agostini de Moraes Open the ORCID record for Mariana Agostini de Moraes [Opens in a new window]  and
Marisa Masumi Beppu
Giovana Maria Genevro
Affiliation:
School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, SP 13083-852, Brazil
Reginaldo Jose Gomes Neto
Affiliation:
School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, SP 13083-852, Brazil
Letícia de Almeida Paulo
Affiliation:
Environmental, Chemical and Pharmaceutical Sciences Institute, Department of Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP 09913-030, Brazil
Patrícia Santos Lopes
Affiliation:
Environmental, Chemical and Pharmaceutical Sciences Institute, Department of Pharmaceutical Sciences, Universidade Federal de São Paulo, Diadema, SP 09913-030, Brazil
Mariana Agostini de Moraes
Affiliation:
Environmental, Chemical and Pharmaceutical Sciences Institute, Department of Chemical Engineering, Universidade Federal de São Paulo, Diadema, SP 09913-030, Brazil
Marisa Masumi Beppu*
Affiliation:
School of Chemical Engineering, Department of Materials and Bioprocess Engineering, University of Campinas, Campinas, SP 13083-852, Brazil
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Asymmetric membranes present promising characteristics for wound dressing applications. A porous structure uptakes the wound exudate, whereas an occlusive layer (upper film) inhibits the microbial penetration and prevents an excessive loss of water. Konjac glucomannan (KGM) is a natural polysaccharide that has been investigated as wound dressings in the form of films, sponges, and hydrogels due to its flexibility, swelling capacity, biocompatibility, and low cost. However, there are no studies on literature regarding the development of KGM asymmetric membranes. In this study, we investigated a new casting–freezing process for the production of KGM asymmetric membranes. The scanning electron microscopy and thermogravimetric analyses indicated an asymmetric morphology and a good thermal stability of the membrane samples, respectively. Moreover, biological, mechanical, and fluid-handling capacity tests showed that the membrane is biocompatible and resistant to handling structure, which was also able to retain the ideal moist conditions for wound healing.

Keywords

polymersfilmporosity
Type
Invited Paper
Information
Journal of Materials Research , Volume 34 , Issue 4 , 28 February 2019 , pp. 481 - 489
Copyright
Copyright © Materials Research Society 2019. This is a work of the U.S. Government and is not subject to copyright protection in the United States. 

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Footnotes

b)

These authors contributed equally to this work.

This article has been corrected since its original publication. See doi:10.1557/jmr.2019.315.

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