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Effects of poly(para-dioxanone-co-L-lactide) on the in vitro hydrolytic degradation behaviors of poly(L-lactide)/poly(para-dioxanone) blends

Published online by Cambridge University Press:  17 February 2015

Xulong Xie ,
Wei Bai ,
Congming Tang ,
Dongliang Chen  and
Chengdong Xiong
Xulong Xie
Affiliation:
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China; and University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China
Wei Bai*
Affiliation:
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China
Congming Tang
Affiliation:
Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, Nanchong 637009, People's Republic of China
Dongliang Chen
Affiliation:
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China
Chengdong Xiong
Affiliation:
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Poly(L-lactide)/poly(para-dioxanone) (PLLA/PPDO) (85/15 w/w) blends with 0, 1, 3, and 5 wt% poly(para-dioxanone-co-L-lactide) (PDOLLA) as a compatibilizer were prepared by solution coprecipitation. The in vitro hydrolytic degradation (HD) of blend bars with different contents of PDOLLA was studied by immersing the bars in a phosphate buffer solution (PBS) at pH 7.49. To estimate the degradation of blend bars, the weight loss, water absorption, thermal properties, surface morphology, and mechanical properties of blend bars, as well as the pH value changes of the PBS, were studied for 8 wk of HD. By adding 1 and 3 wt% PDOLLA, the weight loss of PLLA/PPDO (85/15 w/w) blends increased from 6.4 to 6.8 and 7.4% after 8 wk of HD, 6.2 and 15.6% increment, respectively, while, the average tensile strength of PLLA/PPDO (85/15 w/w) blends for 2–8 wk of HD increased from 25.8 to 29.0 MPa and 31.0 MPa, 12.4 and 20.2% increment, respectively. Considering their good mechanical properties and HD rate, the PLLA/PPDO (85/15 w/w) blends with 1 and 3 wt% PDOLLA are potential to be used as a medical implant material.

Keywords

blendbiomedicalpolymer
Type
Articles
Information
Journal of Materials Research , Volume 30 , Issue 6 , 28 March 2015 , pp. 860 - 868
Copyright
Copyright © Materials Research Society 2015 

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