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Effects of cerium addition on the corrosion resistance and biocompatibility of Mg–2Sr–1Zr Alloy

Published online by Cambridge University Press:  21 September 2020

Sourav Dutta ,
Santanu Mandal ,
Sanjay Gupta  and
Mangal Roy
Sourav Dutta
Affiliation:
Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur721302, India
Santanu Mandal
Affiliation:
Department of Metallurgical and Materials Engineering, Indian Institute of Technology Kharagpur, Kharagpur721302, India
Sanjay Gupta
Affiliation:
Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur721302, India
Mangal Roy*
Affiliation:
Department of Metallurgical and Materials Engineering, Indian Institute of Technology Kharagpur, Kharagpur721302, India
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

There is a significant interest in developing the corrosion-resistant magnesium (Mg) alloy as a degradable biomaterial. In this work, the magnesium–zirconium (Zr = 1 wt%)–strontium (Sr = 2 wt%)–cerium (Ce = 0, 0.5 wt%) alloy was developed using the casting process. Effects of Ce addition on alloy microstructure, corrosion behavior, and biocompatibility were systematically investigated. Detailed microstructural analysis indicated that 0.5 wt% Ce addition refined the second phase (Mg17Sr2) in the Mg–2Sr–1Zr alloy. Furthermore, phase analysis of corrosion product showed the formation of stable CeO2 oxide layer on the corroded surface of the Mg alloy. Both the precipitate refinement and stable CeO2 layer formation significantly contributed toward enhanced corrosion resistance of the Mg–Sr–Zr–Ce alloy, as determined by both electrochemical and immersion corrosion in phosphate-buffered saline. Significantly higher osteoblast-like cell (MG-63) proliferation was observed in Ce-containing Mg alloy at both day 1 and day 3. Overall, the results showed that Ce addition could modulate degradation behavior and biocompatibility of the ternary Mg alloy.

Keywords

magnesiumdegradable biomaterialcorrosion resistancemicro-CTin vitro biocompatibility
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 22 , 30 November 2020 , pp. 3124 - 3135
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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References

Witte, F., Fischer, J., Nellesen, J., Crostack, H-A., Kaese, V., Pisch, A., Beckmann, F., and Windhagen, H.: In vitro and in vivo corrosion measurements of magnesium alloys. Biomaterials 27, 1013 (2006).CrossRefGoogle ScholarPubMed
Witte, F.: Reprint of: The history of biodegradable magnesium implants: A review. Acta Biomater. 23, S28 (2015).CrossRefGoogle ScholarPubMed
Xin, Y., Liu, C., Zhang, X., Tang, G., Tian, X., and Chu, P.K.: Corrosion behavior of biomedical AZ91 magnesium alloy in simulated body fluids. J. Mater. Res. 22, 2004 (2007).CrossRefGoogle Scholar
Chen, Y., Xu, Z., Smith, C., and Sankar, J.: Recent advances on the development of magnesium alloys for biodegradable implants. Acta Biomater. 10, 4561 (2014).CrossRefGoogle ScholarPubMed
Kottuparambil, R.R., Bontha, S., Rangarasaiah, R.M., Arya, S.B., Jana, A., Das, M., Balla, V.K., Amrithalingam, S., and Prabhu, T.R.: Effect of zinc and rare-earth element addition on mechanical, corrosion, and biological properties of magnesium. J. Mater. Res. 33, 3466 (2018).CrossRefGoogle Scholar
Saha, P., Roy, M., Datta, M.K., Lee, B., and Kumta, P.N.: Effects of grain refinement on the biocorrosion and in vitro bioactivity of magnesium. Mater. Sci. Eng. C 57, 294 (2015).CrossRefGoogle ScholarPubMed
Li, Y., Wen, C., Mushahary, D., Sravanthi, R., Harishankar, N., Pande, G., and Hodgson, P.: Mg–Zr–Sr alloys as biodegradable implant materials. Acta Biomater. 8, 3177 (2012).CrossRefGoogle ScholarPubMed
Pors Nielsen, S.: The biological role of strontium. Bone 35, 583 (2004).CrossRefGoogle ScholarPubMed
Meunier, P.J., Roux, C., Ortolani, S., Diaz-Curiel, M., Compston, J., Marquis, P., Cormier, C., Isaia, G., Badurski, J., Wark, J.D., Collette, J., and Reginster, J.Y.: Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Osteoporos. Int. 20, 1663 (2009).CrossRefGoogle ScholarPubMed
Ding, Y., Lin, J., Wen, C., Zhang, D., and Li, Y.: Mechanical properties, corrosion, and biocompatibility of Mg-Zr-Sr-Dy alloys for biodegradable implant applications. J. Biomed. Mater. Res. B Appl. Biomater. 106, 2425 (2018).CrossRefGoogle ScholarPubMed
Ding, Y., Lin, J., Wen, C., Zhang, D., and Li, Y.: Mechanical properties, in vitro corrosion and biocompatibility of newly developed biodegradable Mg-Zr-Sr-Ho alloys for biomedical applications. Sci. Rep. 6, 31990 (2016).CrossRefGoogle ScholarPubMed
Song, Y.L., Liu, Y.H., Wang, S.H., Yu, S.R., and Zhu, X.Y.: Effect of cerium addition on microstructure and corrosion resistance of die cast AZ91 magnesium alloy. Mater. Corros. 58, 189 (2007).CrossRefGoogle Scholar
Xie, F., Shen, J., Song, H., and Xie, X.: Effects of cerium and SiC mixed particles on nanoparticle strengthening activated TIG-welded AZ31 alloy joints. J. Mater. Res. 33, 4340 (2018).CrossRefGoogle Scholar
Phatai, P., Futalan, C.M., Utara, S., Khemthong, P., and Kamonwannasit, S.: Structural characterization of cerium-doped hydroxyapatite nanoparticles synthesized by an ultrasonic-assisted sol-gel technique. Results Phys. 10, 956 (2018).CrossRefGoogle Scholar
Priyadarshini, B. and Vijayalakshmi, U.: Development of cerium and silicon co-doped hydroxyapatite nanopowder and its in vitro biological studies for bone regeneration applications. Adv. Powder Technol. 29, 2792 (2018).CrossRefGoogle Scholar
Hu, Y., Du, Y., Jiang, H., and Jiang, G-S.: Cerium promotes bone marrow stromal cells migration and osteogenic differentiation via Smad1/5/8 signaling pathway. Int. J. Clin. Exp. Pathol. 7, 5369 (2014).Google ScholarPubMed
Zhang, J., Liu, C., Li, Y., Sun, J., Wang, P., Di, K., and Zhao, Y.: Effect of cerium ion on the proliferation, differentiation and mineralization function of primary mouse osteoblasts in vitro. J. Rare Earths 28, 138 (2010).CrossRefGoogle Scholar
Zhao, C., Pan, F., Zhang, L., Pan, H., Song, K., and Tang, A.: Microstructure, mechanical properties, bio-corrosion properties and cytotoxicity of as-extruded Mg-Sr alloys. Mater. Sci. Eng. C 70, 1081 (2017).CrossRefGoogle ScholarPubMed
Brar, H.S., Wong, J., and Manuel, M.V.: Investigation of the mechanical and degradation properties of Mg–Sr and Mg–Zn–Sr alloys for use as potential biodegradable implant materials. J. Mech. Behav. Biomed. Mater. 7, 87 (2012).CrossRefGoogle ScholarPubMed
Munir, K., Lin, J., Wen, C., Wright, P.F.A., and Li, Y.: Mechanical, corrosion, and biocompatibility properties of Mg-Zr-Sr-Sc alloys for biodegradable implant applications. Acta Biomater. 102, 493 (2020).CrossRefGoogle ScholarPubMed
Atrens, A., Song, G-L., Liu, M., Shi, Z., Cao, F., and Dargusch, M.S.: Review of recent developments in the field of magnesium corrosion. Adv. Eng. Mater. 17, 400 (2015).CrossRefGoogle Scholar
Willbold, E., Gu, X., Albert, D., Kalla, K., Bobe, K., Brauneis, M., Janning, C., Nellesen, J., Czayka, W., Tillmann, W., Zheng, Y., and Witte, F.: Effect of the addition of low rare earth elements (lanthanum, neodymium, cerium) on the biodegradation and biocompatibility of magnesium. Acta Biomater. 11, 554 (2015).CrossRefGoogle ScholarPubMed
Liu, J., Lin, Y., Bian, D., Wang, M., Lin, Z., Chu, X., Li, W., Liu, Y., Shen, Z., Liu, Y., Tong, Y., Xu, Z., Zhang, Y., and Zheng, Y.: In vitro and in vivo studies of Mg-30Sc alloys with different phase structure for potential usage within bone. Acta Biomater. 98, 50 (2019).CrossRefGoogle ScholarPubMed
Bian, D., Deng, J., Li, N., Chu, X., Liu, Y., Li, W., Cai, H., Xiu, P., Zhang, Y., Guan, Z., Zheng, Y., Kou, Y., Jiang, B., and Chen, R.: In vitro and in vivo studies on biomedical magnesium low-alloying with elements gadolinium and zinc for orthopedic implant applications. ACS Appl. Mater. Interfaces 10, 4394 (2018).CrossRefGoogle ScholarPubMed
Gui, Z., Kang, Z., and Li, Y.: Mechanical and corrosion properties of Mg-Gd-Zn-Zr-Mn biodegradable alloy by hot extrusion. J. Alloys Compd. 685, 222 (2016).CrossRefGoogle Scholar
Dutta, S., Devi, K.B., Mandal, S., Mahato, A., Gupta, S., Kundu, B., Balla, V.K., and Roy, M.: In vitro corrosion and cytocompatibility studies of hot press sintered magnesium-bioactive glass composite. Materialia 5, 100245 (2019).CrossRefGoogle Scholar
Dutta, S., Devi, K.B., Gupta, S., Kundu, B., Balla, V.K., and Roy, M.: Mechanical and in vitro degradation behavior of magnesium-bioactive glass composites prepared by SPS for biomedical applications. J. Biomed. Mater. Res. B Appl. Biomater. 107, 352 (2019).CrossRefGoogle ScholarPubMed
Dutta, S., Bavya Devi, K., and Roy, M.: Processing and degradation behavior of porous magnesium scaffold for biomedical applications. Adv. Powder Technol. 28, 3204 (2017).CrossRefGoogle Scholar
Zhao, M-C., Liu, M., Song, G-L., and Atrens, A.: Influence of pH and chloride ion concentration on the corrosion of Mg alloy ZE41. Corros. Sci. 50, 3168 (2008).CrossRefGoogle Scholar