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Development of bioceramic bone scaffolds by introducing triple liquid phases

Published online by Cambridge University Press:  11 October 2016

Cijun Shuai ,
Songlin Duan ,
Ping Wu ,
Dan Gao ,
Pei Feng ,
Chengde Gao  and
Shuping Peng
Cijun Shuai
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China; and State Key Laboratory for Powder Metallurgy, Central South University, Changsha 410083, People's Republic of China
Songlin Duan
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Ping Wu
Affiliation:
College of Chemistry, Xiangtan University, Xiangtan 411105, People's Republic of China
Dan Gao
Affiliation:
School of Basic Medical Science, Central South University, Changsha 410078, People's Republic of China
Pei Feng
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Chengde Gao
Affiliation:
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha 410083, People's Republic of China
Shuping Peng*
Affiliation:
Key Laboratory of Carcinogenesis of the Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha 410078, People's Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha 410078, People's Republic of China; and Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha 410013, People's Republic of China
*
a) Address all correspondence to this author. e-mail: [email protected]
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Abstract

In this study, a system of triple liquid phases was developed using Li2CO3, Na2CO3, and K2CO3 to improve the densification of the akermanite scaffolds fabricated by selective laser sintering (SLS). The system formed a ternary liquid phase (Li2CO3–Na2CO3–K2CO3) at 399 °C, a binary liquid phase (Na2CO3–K2CO3) at 695 °C, and a unitary liquid phase (K2CO3) at 891 °C during sintering process. The effects of the liquid phases on the sinterability and mechanical properties of the scaffolds were investigated. The fracture toughness and compressive strength is increased by 43 and 152% with liquid phases increasing from 0 to 4 wt%, respectively. This was explained that liquid phases enhanced densification via improving diffusion kinetics and inducing particle rearrangement. In addition, the scaffolds maintained favorable hydroxyapatite (HA) formation ability and cell proliferation ability, which was proved by simulated body fluid (SBF) test and microculture tetrazolium test (MTT), respectively.

Keywords

biomaterialdensificationlaser
Type
Articles
Information
Journal of Materials Research , Volume 31 , Issue 22 , 28 November 2016 , pp. 3498 - 3505
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Copyright
Copyright © Materials Research Society 2016 

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