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The control of morphological and size properties of carbamazepine-imprinted microspheres and nanospheres under different synthesis conditions

Published online by Cambridge University Press:  27 September 2013

Mehdi Esfandyari-Manesh ,
Mehran Javanbakht ,
Elnaz Shahmoradi ,
Rassoul Dinarvand  and
Fatemeh Atyabi
Mehdi Esfandyari-Manesh*
Affiliation:
Department of Chemistry, Amirkabir University of Technology, Tehran, Iran; and Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Mehran Javanbakht
Affiliation:
Department of Chemistry, Amirkabir University of Technology, Tehran, Iran; and Nano Science and Technology Research Center, Amirkabir University of Technology, Tehran, Iran
Elnaz Shahmoradi
Affiliation:
Department of Chemical Engineering, Sharif University of Technology, Tehran, Iran
Rassoul Dinarvand
Affiliation:
Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
Fatemeh Atyabi
Affiliation:
Nanotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Potential applications of the molecularly imprinted polymers (MIPs) demand physical configurations in different size ranges. Nowadays, research on MIPs is focused on the development of new or improved morphologies, which involves control and modification of the different parameters during the synthesis. In this study, the effect of different synthesis conditions on the particle size and morphology is investigated. Carbamazepine-imprinted polymers were prepared using precipitation polymerization under various conditions such as: the amounts of cross-linker and functional monomers, initiator, porogen, temperature and time of polymerization. We studied the polymerization conditions to obtain imprinted spherical particles with controllable sizes in the range of 243 nm to 3.4 μm. Scanning electron microscopy and photon correlation spectroscopy were utilized to investigate the morphological characterization. The mole ratio of the functional monomer to the cross-linker was important to obtain smaller uniformly sized particles. In addition, the results showed that the cross-linker in the molecular imprinting synthesis can affect the morphology and composition of the MIPs, which influences the binding affinity.

Keywords

molecular imprintingprecipitation polymerizationsynthesis conditionsnanospheremorphology
Type
Articles
Information
Journal of Materials Research , Volume 28 , Issue 19 , 14 October 2013 , pp. 2677 - 2686
Copyright
Copyright © Materials Research Society 2013 

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