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Chitosan-poly(acrylic acid) complex modified paramagnetic Fe3O4 nanoparticles for camptothecin loading and release

Published online by Cambridge University Press:  31 January 2011

Aiping Zhu ,
Xiadan Luo  and
Sheng Dai
Aiping Zhu*
Affiliation:
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, People's Republic of China
Xiadan Luo
Affiliation:
College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, People's Republic of China
Sheng Dai
Affiliation:
Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6
*
a) Address all correspondence to this author. e-mail: [email protected]
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Abstract

The stable superparamagnetic colloidal suspension of chitosan-poly(acrylic acid) (CS-PAA)/Fe3O4 nanoparticles was synthesized by graft copolymerization AA on the surface of CS stabilized Fe3O4 nanoparticles. The size, size distribution, structure, and magnetic properties of the resultant CS-PAA/Fe3O4 nanoparticles were characterized by field-emission scanning electron microscopy (FE-SEM), transmission electron microscope (TEM), dynamic light scattering, Fourier transform infrared spectroscopy, x-ray diffraction, and vibrating sample magnetometry (VSM). FE-SEM and TEM showed the spherelike morphology of CS-PAA/Fe3O4 nanoparticles with their diameter ranging from 15 to 60 nm. VSM measurements indicated that CS-PAA/Fe3O4 nanoparticles preserved the superparamagnetism. CS-PAA complex was proved to be a good stabilizer to prepare the well-dispersed suspension of superparamagnetic Fe3O4 nanoparticles. The stabilizing mechanisms were attributed to the electrostatic repulsion and steric hindrance. The controlled release of entrapped camptothecin from these magnetic nanoparticles was studied and the release mechanism was analyzed.

Keywords

BiomaterialColloidNanostructure
Type
Articles
Information
Journal of Materials Research , Volume 24 , Issue 7 , July 2009 , pp. 2307 - 2315
Copyright
Copyright © Materials Research Society 2009

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References

1Dyal, A., Loos, K., Noto, M., Chang, S.W., Spagnoli, C., Shafi, K.V.P.M., Ulman, A., Cowman, M., and Gross, R.A.: Activity of Candida rugosa lipase immobilized on g-Fe2O3 magnetic nanoparticles. J. Am. Chem. Soc. 125, 1684 (2003).CrossRefGoogle Scholar
2Guo, Q., Teng, X., Rahman, S., and Yang, H.: Patterned Langmuir–Blodgett films of monodisperse nanoparticles of iron oxide using soft lithography. J. Am. Chem. Soc. 125, 630 (2003).Google Scholar
3Sun, S., Murray, C.B., Weller, D., Folks, L., and Moser, A.: Monodisperse FePt nanoparticles and ferromagnetic FePt nanocrystal superlattices. Science 287, 1989 (2000).Google Scholar
4Maclachlan, H.J., Ginzburg, M., Coombs, N., Coyle, T.W., Raju, N.P., Greedan, J.E., Ozin, G.A., and Manners, I.: Shaped ceramics with tunable magnetic properties from metal-containing polymers. Science 287, 1460 (2000).CrossRefGoogle ScholarPubMed
5Sieben, S., Bergemann, C., Lubbe, A., Brockmann, B., and Rescheleit, D.: Comparison of different particles and methods for magnetic isolation of circulating tumor cells. J. Magn. Magn. Mater. 225, 175 (2001).Google Scholar
6Gomez-Lopera, S.A., Plaza, R.C., and Delgado, A.V.: Synthesis and characterization of spherical magnetite/biodegradable polymer composite particles. J. Colloid Interface Sci. 240, 40 (2001).Google Scholar
7Sonvico, F., Mornet, S., Vasseur, S., Dubernet, C., Jaillard, D., Degrouard, J., Hoebeke, J., Duguet, E., Colombo, P., and Couvreur, P.: Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators: Synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chem. 16, 1181 (2005).Google Scholar
8Wunderbaldinger, P., Josephson, L., and Weissleder, R.: Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjugate Chem. 13, 264 (2002).Google Scholar
9Kim, D.K., Zhang, Y., Kehr, J., Klason, T., Bjelke, B., and Muhammed, M.: Characterization and MRI study of surfactantcoated superparamagnetic nanoparticles administered into the rat brain. J. Magn. Magn. Mater. 225, 256 (2001).CrossRefGoogle Scholar
10Morishita, N., Nakagami, H., Morishita, R., Takeda, S., Mishima, F., Terazono, B., Nishijima, S., Kaneda, Y., and Tanaka, N.: Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-evector. Biochem. Biophys. Res. Commun. 334, 1121 (2005).Google Scholar
11Shen, L., Laibinis, P.E., and Hatton, T.A.: Bilayer surfactant stabilized magnetic fluids: Synthesis and interactions at interfaces. Langmuir 15, 447 (1999).CrossRefGoogle Scholar
12Kim, D.K., Mikhaylova, M., Zhang, Y., and Muhammed, M.: Protective coating of superparamagnetic iron oxide nanoparticles. Chem. Mater. 15, 1617 (2003).CrossRefGoogle Scholar
13Harris, L.A., Goff, J.D., Carmichael, A.Y., Riffle, J.S., Harburn, J.J., St. Pierre, T.G., and Saunders, M.: Magnetite nanoparticle dispersions stabilized with triblockcopolymers. Chem. Mater. 15, 1367 (2003).Google Scholar
14Wan, S., Zheng, Y., Liu, Y., Yan, H., and Liu, K.: Fe3O4 nanoparticles coated with homopolymers of glycerol mono(meth)acrylate and their block copolymers. J. Mater. Chem. 15, 3424 (2005).Google Scholar
15Wan, S., Huang, J., Yan, H., and Liu, K.: Sized-controlled preparation of magnetic nanoparticles in the presence of graft copolymers. J. Mater. Chem. 16, 298 (2006).CrossRefGoogle Scholar
16Gupta, A.K. and Gupta, M.: Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 26, 1565 (2005).Google Scholar
17Berry, C.C., Wells, S., Charles, S., and Curtis, A.S.G.: Dextran and albumin derivatised iron oxide nanoparticles: Influence on fibroblasts in vitro. Biomaterials 24, 4551 (2003).CrossRefGoogle ScholarPubMed
18Berry, C.C., Wells, S., Charles, S., Aitchison, G., and Curtis, A.S.G.: Cell response to dextran-derivatised iron oxide nanoparticles post internalization. Biomaterials 25, 5405 (2004).Google Scholar
19Kim, D.K., Mikhaylova, M., Wang, F.H., Kehr, J., Bjelke, B., Zhang, Y., Tsakalakos, T., and Muhammed, M.: Starch-coated superparamagnetic nanoparticles as MR contrast agents. Chem. Mater. 15, 4343 (2003).CrossRefGoogle Scholar
20Mikhaylova, M., Kim, D.K., Berry, C.C., Zagorodni, A., Toprak, M., Curtis, A.S.G., and Muhammed, M.: BSA immobilization on amine-functionalized superparamagnetic iron oxide nanoparticles. Chem. Mater. 16, 2344 (2004).CrossRefGoogle Scholar
21Mao, H.Q., Roy, K., Troung-Le, V.L., Janes, K.A., Lin, K.Y., and Wang, Y.: Chitosan-DNA nanoparticles as gene carriers: Synthesis, characterization and transfection efficiency. J. Controlled Release 70, 399 (2001).Google Scholar
22Yoshinori, K., Hiraku, O., and Yoshiharu, M.: Evaluation of N-succinyl-chitosan as a systemic long-circulating polymer. Biomaterials 21, 1579 (2000).Google Scholar
23Illum, L., Jorgensen, H., Bisgaard, H., Krogsgaard, O., and Rossing, N.: Bioadhesive microspheres as a potential nasal drug delivery system. Int. J. Pharm. 39, 189 (1987).Google Scholar
24Zhu, A.P., Yuan, L.H., and Liao, T.Q.: Suspension of Fe3O4 nanoparticles stabilized by chitosan and O-carboxymethylchitosan. Int. J. Pharm. 350, 361 (2008).Google Scholar
25Hu, Y., Chen, Y., Chen, Q., Zhang, L.Y., Jiang, X.Q., and Yang, C.Z.: Synthesis and stimuli-responsive properties of chitosan/poly (acrylic acid) hollow nanospheres. Polymer (Guildf.) 46, 12703 (2005).Google Scholar
26Ding, Y., Hu, Y., Jiang, X.Q., Zhang, L.Y., and Yang, C.Z.: Polymer-monomer pairs as a reaction system for the synthesis of magnetic Fe3O4-polymer hybrid hollow nanospheres. Angew. Chem. Int. Ed. 43, 6369 (2004).Google Scholar
27Zhang, L.Y., Yang, M., Wang, Q., Li, Y.L., Guo, R., Jiang, X.Q., Yang, C.Z., and Liu, B.R.: 10-Hydroxycamptothecin loaded nanoparticles: Preparation and antitumor activity in mice. J. Controlled Release 119, 153 (2007).Google Scholar
28Zhu, A.P., Liu, J.H., and Ye, W.H.: Preparation of the well-disperse effective loading and controlled release of camptothecin by O-carboxymethylchitosan aggregates. Carbohydr. Polym. 63, 89 (2006).Google Scholar
29Wu, Y., Guo, J., Yang, W.L., Wang, C.C., and Fu, S.K.: Preparation and characterization of chitosan-poly(acrylic acid) polymer magnetic microspheres. Polymer (Guildf.) 471, 5287 (2006).CrossRefGoogle Scholar
30Ma, Z.Y., Guan, Y.P., and Liu, H.Z.: Synthesis and characterization of micron-sized monodisperse superparamagnetic polymer particles with amino groups. J. Polym. Sci., Part A: Polym. Chem. 43, 3433 (2005).Google Scholar