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Antibacterial metal ion release from diamond-like carbon modified surfaces for novel multifunctional implant materials

Published online by Cambridge University Press:  09 August 2016

Sascha Buchegger ,
Caroline Vogel ,
Rudolf Herrmann ,
Bernd Stritzker ,
Achim Wixforth  and
Christoph Westerhausen
Sascha Buchegger
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany
Caroline Vogel
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany
Rudolf Herrmann
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany
Bernd Stritzker
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany
Achim Wixforth
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany; Nanosystems Initiative Munich, Munich 80799, Germany; and Augsburg Center for Innovative Technologies (ACIT), Augsburg 86159, Germany
Christoph Westerhausen*
Affiliation:
Chair for Experimental Physics 1, University of Augsburg, Augsburg 86159, Germany; Nanosystems Initiative Munich, Munich 80799, Germany; and Augsburg Center for Innovative Technologies (ACIT), Augsburg 86159, Germany
*
a) Address all correspondence to this author. e-mail: [email protected]
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Abstract

The aim of this study was the synthesis of hard and low-abrasive novel implant materials with built-in time-dependent antibacterial properties, which can be tailored by a well-defined time-dependent and finite release of metal ions. We were able to synthesize such smart implant surfaces employing ECR (electron cyclotron resonance)-plasma on typical titanium implant material by transforming a polymer film into diamond-like carbon (DLC) which contains metal nanoparticles as reservoirs for controlled metal ion release. We found that the amount of released antibacterial metal ions is a biexponential function of time with a high release rate during the first few hours followed by a decreased ion release rate within the following days. To describe our experimental findings, we developed a kinetic model assuming that both nanoparticles near the surface and nanoparticles in the DLC bulk contribute to the total amount of ions released with different time constants.

Keywords

biomedicalion-beam processingsol–gel
Type
Articles
Information
Journal of Materials Research , Volume 31 , Issue 17 , 14 September 2016 , pp. 2571 - 2577
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Copyright
Copyright © Materials Research Society 2016 

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References

REFERENCES

Pauksch, L., Rohnke, M., Schnettler, R., and Lips, K.S.: Silver nanoparticles do not alter human osteoclastogenesis but induce cellular uptake. Toxicol. Rep. 1, 900–908 (2014).Google Scholar
Grandfield, K.: Bone, implants, and their interfaces. Phys. Today 68, 40–45 (2015).CrossRefGoogle Scholar
Monteiro, D.R., Gorup, L.F., Takamiya, A.S., Ruvollo-Filho, A.C., de Camargo, E.R., and Barbosa, D.B.: The growing importance of materials that prevent microbial adhesion: Antimicrobial effect of medical devices containing silver. Int. J. Antimicrob. Agents 34, 103–110 (2009).Google Scholar
McCoy, C.P., Craig, R.A., McGlinchey, S.M., Carson, L., Jones, D.S., and Gorman, S.P.: Surface localisation of photosensitisers on intraocular lens biomaterials for prevention of infectious endophthalmitis and retinal protection. Biomaterials 33, 7952–7958 (2012).Google Scholar
Mohammed, M.T., Khan, Z.A., and Siddiquee, A.N.: Surface modifications of titanium materials for developing corrosion behavior in human body environment: A review. Procedia Mater. Sci. 6, 1610–1618 (2014).Google Scholar
Gutensohn, K., Beythien, C., Bau, J., Fenner, T., Grewe, P., Koester, R., Padmanaban, K., and Kuehnl, P.: In vitro analyses of diamond-like carbon coated stents. Thromb. Res. 99, 577–585 (2000).Google Scholar
Marciano, F.R., Lima-Oliveira, D.A., Da-Silva, N.S., Diniz, A.V., Corat, E.J., and Trava-Airoldi, V.J.: Antibacterial activity of DLC films containing TiO2 nanoparticles. J. Colloid Interface Sci. 340, 87–92 (2009).Google Scholar
Schwarz, F. and Stritzker, B.: Plasma immersion ion implantation of polymers and silver–polymer nano composites. Surf. Coat. Technol. 204, 1875–1879 (2010).Google Scholar
Elkhawass, E.A., Mohallal, M.E., and Soliman, M.F.M.: Acute toxicity of different sizes of silver nanoparticles intraperitoneally injected in balb/c mice using two toxicological methods. Int. J. Pharm. Pharm. Sci. 7, 94–99 (2015).Google Scholar
Damm, C. and Münstedt, H.: Kinetic aspects of the silver ion release from antimicrobial polyamide/silver nanocomposites. Appl. Phys. A 91, 479–486 (2008).Google Scholar
Ma, H., Williams, P.L., and Diamond, S.A.: Ecotoxicity of manufactured ZnO nanoparticles—A review. Environ. Pollut. 172, 76–85 (2013).Google Scholar
Karlsson, H.L., Cronholm, P., Hedberg, Y., Tornberg, M., De Battice, L., Svedhem, S., and Wallinder, I.O.: Cell membrane damage and protein interaction induced by copper containing nanoparticles—Importance of the metal release process. Toxicology 313, 59–69 (2013).Google Scholar
Salem, W., Leitner, D.R., Zingl, F.G., Schratter, G., Prassl, R., Goessler, W., Reidl, J., and Schild, S.: Antibacterial activity of silver and zinc nanoparticles against Vibrio cholerae and enterotoxic Escherichia coli . Int. J. Med. Microbiol. 305, 85–95 (2015).Google Scholar
Ma, H., Williams, P.L., and Diamond, S.a.: Ecotoxicity of manufactured ZnO nanoparticles—A review. Environ. Pollut. 172, 76–85 (2013).CrossRefGoogle ScholarPubMed
Sowa-Söhle, E.N., Schwenke, A., Wagener, P., Weiss, A., Wiegel, H., Sajti, C.L., Haverich, A., Barcikowski, S., and Loos, A.: Antimicrobial efficacy, cytotoxicity, and ion release of mixed metal (Ag, Cu, Zn, Mg) nanoparticle polymer composite implant material. BioNanoMaterials 14, 217–227 (2013).Google Scholar
Chaloupka, K., Malam, Y., and Seifalian, A.M.: Nanosilver as a new generation of nanoproduct in biomedical applications. Trends Biotechnol. 28, 580–588 (2010).Google Scholar
Allaker, R.P.: The use of nanoparticles to control oral biofilm formation. J. Dent. Res. 89, 1175–1186 (2010).CrossRefGoogle ScholarPubMed
Aydin Sevinç, B. and Hanley, L.: Antibacterial activity of dental composites containing zinc oxide nanoparticles. J. Biomed. Mater. Res., Part B 94B, 22–31 (2010).Google Scholar
Schwarz, F.P., Hauser-Gerspach, I., Waltimo, T., and Stritzker, B.: Antibacterial properties of silver containing diamond like carbon coatings produced by ion induced polymer densification. Surf. Coat. Technol. 205, 4850–4854 (2011).Google Scholar
Zhang, W., Zhang, Y., Ji, J., Yan, Q., Huang, A., and Chu, P.K.: Antimicrobial polyethylene with controlled copper release. J. Biomed. Mater. Res., Part A 83A, 838–844 (2007).CrossRefGoogle Scholar
Chu, P.K.: Applications of plasma-based technology to microelectronics and biomedical engineering. Surf. Coat. Technol. 203, 2793–2798 (2009).Google Scholar
Francz, G., Schröder, A., and Hauert, R.: Surface analysis and bioreactions of Ti- and V-containing a-C: H. Surf. Interface Anal. 28, 3–7 (1999).Google Scholar
Hauert, R.: A review of modified DLC coatings for biological applications. Diamond Relat. Mater. 12, 583–589 (2003).CrossRefGoogle Scholar
Demir, M.M., Munoz-Espi, R., Lieberwirth, I., and Wegner, G.: Precipitation of monodisperse ZnO nanocrystals via acid-catalyzed esterification of zinc acetate. J. Mater. Chem. 16, 2940 (2006).Google Scholar
Herrmann, R., García-García, F.J., and Reller, A.: Rapid degradation of zinc oxide nanoparticles by phosphate ions. Beilstein J. Nanotechnol. 5, 2007–2015 (2014).Google Scholar
Chowdury, P.P., Shaik, A.H., and Chakraborty, J.: Preparation of stable sub 10 nm copper nanopowders redispersible in polar and non-polar solvents. Colloids Surf., A 466, 189–196 (2015).Google Scholar
Schwarz, F.P.: Ph.D. thesis, University of Augsburg, (2010).Google Scholar
Robertson, J.: Diamond-like amorphous carbon. Mater. Sci. Eng., R 37, 129–281 (2002).Google Scholar
Zhang, W., Yao, Y., Sullivan, N., and Chen, Y.S.: Modeling the primary size effects of citrate-coated silver nanoparticles on their ion release kinetics. Environ. Sci. Technol. 45, 4422–4428 (2011).Google Scholar
Meulenkamp, E.A.: Size dependence of the dissolution of ZnO nanoparticles. J. Phys. Chem. B 102, 7764–7769 (1998).Google Scholar
Ho, C-M., Yau, S.K-W., Lok, C-N., So, M-H., and Che, C-M.: Oxidative dissolution of silver nanoparticles by biologically relevant oxidants: A kinetic and mechanistic study. Chem. –Asian J. 5, 285–293 (2010).Google Scholar
Visuri, T. and Kiviluoto, O.: Arthroscopic volume of the knee joint in young male adults. Scand. J. Rheumatol. 15, 251–254 (1986).Google Scholar
Chernousova, S. and Epple, M.: Silver as antibacterial Agent: Ion, nanoparticle, and metal. Angew. Chem., Int. Ed. 52, 1636–1653 (2013).Google Scholar