Hostname: page-component-586b7cd67f-2brh9 Total loading time: 0 Render date: 2024-11-26T04:50:45.175Z Has data issue: false hasContentIssue false
  • English
  • Français

Variations of structure and composition in magnesium incorporated hydroxyapatite/β-tricalcium phosphate

Published online by Cambridge University Press:  01 February 2006

Hyun-Seung Ryu ,
Kug Sun Hong ,
Jung-Kun Lee  and
Deug Joong Kim
Hyun-Seung Ryu
Affiliation:
R&D Center, Bioalpha Inc., Seongnam, Kyonggi 462-807, Korea
Kug Sun Hong*
Affiliation:
School of Materials Science & Engineering, Seoul National University, Seoul 151-742, Korea
Jung-Kun Lee
Affiliation:
Los Alamos National Laboratory, Los Alamos, New Mexico 87545
Deug Joong Kim
Affiliation:
Department of Materials Engineering, Sungkyunkwan University, Suwon 440-746, Korea
*
a)Address all correspondence to this author. e-mail: [email protected]
Get access

Abstract

The phase evolution of magnesium incorporated hydroxyapatite/β-tricalcium phosphate (HA/β-TCP) ceramics of high purity prepared by solid-state reaction was investigated with the aid of x-ray diffraction and infrared spectroscopy (IR) in transmittance mode analysis. The dependence of the microstructure on the phase evolution of biphasic ceramics during natural sintering was also investigated as a function of Mg content. When sintered at 1100 °C, Mg is preferentially incorporated into the β-TCP phase rather than the HA phase. This Mg incorporation into the β-TCP effectively suppresses the phase transition from β- to α-TCP. With increasing sintering temperature, the solubility limit of the Mg in the β-TCP decreases and Mg starts to be either incorporated into the HA phase or segregated as free MgO. The decreased Mg content in the β-TCP facilitates the phase transition from β- into α-TCP, at 1300 °C or higher. Different processing methods on Mg addition show that the retarded phase transition from β- to α-TCP is the inherent property of Mg-doped HA/TCP. The variations in processing parameters mainly affect the microstructure instead of the phase evolution, leading to highly densified HA/β-TCP ceramics.

Keywords

CeramicPhase transformationSintering
Type
Articles
Information
Journal of Materials Research , Volume 21 , Issue 2 , February 2006 , pp. 428 - 436
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1.Hench, L.L.: Bioceramics. J. Am. Ceram. Soc. 81, 1705 (1998).CrossRefGoogle Scholar
2.Bucholz, R.W.: Nonallograft osteoconductive bone graft substitutes. Clin. Orthop. Res. 395, 44 (2002).CrossRefGoogle Scholar
3.Spivak, J.M. and Hasharoni, A.: Use of hydroxyapatite in spine surgery. Eur. Spine J. 10, S197 (2001).Google Scholar
4.Kivrak, N. and Tas, A. Cuneyt: Synthesis of calcium hydroxyapatitetricalcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior. J. Am. Ceram. Soc. 81(9), 2245 (1998).CrossRefGoogle Scholar
5.Yang, X. and Wang, Z.: Sinthesis of biphasic ceramics of hydroxyapatite and β-ticalcium phosphate with controlled phase content and porosity. J. Mater. Chem. 8, 2233 (1998).CrossRefGoogle Scholar
6.Hardouin, P., Chopin, D., Devyver, B., Flautre, B., Blary, M.C., Guigui, P. and Anselme, K.: Quantitative histomorphometric evaluation of spinal arthrodesis after biphasic calcium phosphate ceramic implantation. J. Mater. Sci. Mater. Med. 3, 212 (1991).CrossRefGoogle Scholar
7.Daculsi, G., Laboux, O., Malard, O. and Weiss, P.: Current state of the art of biphasic calcium phosphate bioceramics. J. Mater. Sci. Mater. Med. 14, 195 (2003).CrossRefGoogle ScholarPubMed
8.Rohanizadeh, R., Padrines, M., Bouler, J.M., Couchourel, D., Fortun, Y. and Daculsi, G.: Apatite precipitation after incubation of biphasic calcium-phosphate ceramic in various solutions: Influence of seed species and proteins. J. Biomed. Mater. Res. 42, 530 (1998).3.0.CO;2-6>CrossRefGoogle ScholarPubMed
9.Daculsi, G., Passuti, N., Martin, S., Deudon, C., Legeros, R.Z. and Raher, S.: Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. J. Biomed. Mater. Res. 24, 379 (1990).CrossRefGoogle ScholarPubMed
10.Taş, A. Cüneyt, Korkusuz, F., Timuçin, M. and Akkaş, N.: An investigation of the chemical synthesis and high-temperature sintering behaviour of calcium hydroxyapatite (HA) and tricalcium phosphate (TCP) bioceramics. J. Mater. Sci. Mater. Med. 8, 91 (1997).Google Scholar
11.Kong, L.B., Ma, J. and Boey, F.: Nanosized hydroxyapatite powders derived from coprecipitation process. J. Mater. Sci. 37, 1131 (2002).Google Scholar
12.Raynaud, S., Champion, E. and Bernache-Assollant, D.: Calcium phosphate apatites with variable Ca/P atomic ratio II. Calcination and sintering. Biomaterials 23, 1073 (2002).CrossRefGoogle ScholarPubMed
13.Ryu, H.S., Youn, H.J., Hong, K.S., Kim, S.J., Lee, D.H., Chang, B.S., Lee, C.K. and Chung, S.S.: Correlation between MgO doping and sintering characteristics in hydroxyapatite/β-tricalcium phosphate composite. Key Eng. Mater. 218, 21 (2002).Google Scholar
14.Ryu, H.S., Hong, K.S., Lee, J.K., Kim, D.J., Lee, J.H., Chang, B.S., Lee, D.H., Lee, C.K. and Chung, S.S.: Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility. Biomaterials 25, 393 (2003).CrossRefGoogle Scholar
15.Serre, C.M., Papillard, M., Chavassieux, P., Voeel, J.C. and Boivin, G.: Influence of magnesium substitution on a collagen–apatite biomaterial on the production of a calcifying matrix by human osteoblasts. J. Biomed. Mater. Res. 42, 626 (1998).3.0.CO;2-S>CrossRefGoogle ScholarPubMed
16. Powder Diffraction File JCPDS Card No. 9-432 (JCPDS International Centre for Diffraction Data, Newton Square, PA) 1997.Google Scholar
17. Powder Diffraction File JCPDS Card No. 9-169 (JCPDS International Centre for Diffraction Data, Newton Square, PA) 1997.Google Scholar
18. Powder Diffraction File JCPDS Card No. 9-348 (JCPDS International Centre for Diffraction Data, Newton Square, PA) 1997.Google Scholar
19. Powder Diffraction File JCPDS Card No. 45-945 (JCPDS International Centre for Diffraction Data, Newton Square, PA) 1997.Google Scholar
20.Balman, N., Legros, R. and Bonel, G.: X-ray diffraction of calcined bone tissue: A reliable method for the determination of bone Ca/P molar ratio. Calcif. Tissue Int. 34, S93 (1982).Google Scholar
21.Ryu, H.S., Youn, H.J., Hong, K.S., Chang, B.S., Lee, C.K. and Chung, S.S.: An improvement in sintering property of β-tricalcium phosphate by addition of calcium phosphate. Biomaterials 23, 909 (2002).CrossRefGoogle Scholar
22.Elliot, J.C.: Structural and Chemistry of the Apatites and Other Calcium Orthophosphates (Elsevier, Amsterdam, The Netherlands, 1994), p. 41.Google Scholar
23.Ando, J.: Tricalcium phosphate and its variation. Bull. Chem. Soc. Jpn. 31, 196 (1958).CrossRefGoogle Scholar
24.Depero, L.E., Bonzi, P., Musei, M. and Casale, C.: Microstructural study of vanadium-titanium oxide powders obtained by laser-induced synthesis. J. Solid State Chem. 111, 247 (1994).CrossRefGoogle Scholar