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Uniaxial and biaxial mechanical behavior of human amnion

Published online by Cambridge University Press:  03 March 2011

Michelle L. Oyen ,
Robert F. Cook ,
Triantafyllos Stylianopoulos ,
Victor H. Barocas ,
Steven E. Calvin  and
Daniel V. Landers
Michelle L. Oyen*
Affiliation:
Department of Biophysical Sciences and Medical Physics, and Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota, Minneapolis, Minnesota 55455
Robert F. Cook
Affiliation:
Independent Consultant, Minneapolis, Minnesota 55413
Triantafyllos Stylianopoulos
Affiliation:
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota 55455
Victor H. Barocas
Affiliation:
Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota 55455
Steven E. Calvin
Affiliation:
Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota,Minneapolis, Minnesota 55455; and Minnesota Perinatal Physicians/Allina Health System, Minneapolis, Minnesota 55407
Daniel V. Landers
Affiliation:
Department of Obstetrics, Gynecology and Women’s Health, University of Minnesota, Minneapolis, Minnesota 55455
*
a)Address all correspondence to this author. Present address: University of Virginia, Center for Applied Biomechanics, 1011 Linden Ave., Charlottesville, VA 22902. e-mail: [email protected] This paper was selected as the Outstanding Meeting Paper for the 2004 MRS Fall Meeting Symposium Y Proceedings, Vol. 844.
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Abstract

Chorioamnion, the membrane surrounding a fetus during gestation, is a structural soft tissue critical for maintaining a successful pregnancy and delivery. However, the mechanical behavior of this tissue membrane is poorly understood. The structural component of chorioamnion is the amnion sublayer, which provides the membrane’s mechanical integrity via a dense collagen network and is the focus of this investigation. Amnion uniaxial and planar equi-biaxial tension testing was performed using cyclic loading and stress-relaxation. Cyclic testing demonstrated dramatic energy dissipation in the first cycle followed by less hysteresis on subsequent cycles. Fractional energy dissipation per cycle was strain dependent, with greatest dissipation at small strain levels. Stress-relaxation testing demonstrated a level-dependent response and continued relaxation after long relaxation times. A nonlinear viscoelastic (separable) hereditary integral approach was inadequate to model the amnion response due to intrinsic coupling of the strain- and time-dependent responses.

Keywords

BiologicalMechanical propertiesMicrostructure
Type
Outstanding Meeting Paper
Information
Journal of Materials Research , Volume 20 , Issue 11 , November 2005 , pp. 2902 - 2909
Copyright
Copyright © Materials Research Society 2005

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References

REFERENCES

1Schmidt, W. The amniotic fluid compartment: The fetal habitat. Advances in Anatomy, Embryology, and Cell Biology 127, (Springer-Verlag, Berlin, Germany, 1992).Google Scholar
2Mercer, B.: Preterm premature rupture of the membranes. Obstet. Gynecol. 101, 178 (2003).Google ScholarPubMed
3Bryant-Greenwood, G.D.: The extracellular matrix of the human fetal membranes: Structure and function. Placenta 19, 1 (1998).CrossRefGoogle ScholarPubMed
4Oxlund, H., Helmig, R., Halaburt, J.T. and Uldbjerg, N.: Biomechanical analysis of human chorioamniotic membranes. Eur. J. Obstet. Gynecol. Reprod. Biol. 34, 247 (1990).CrossRefGoogle ScholarPubMed
5Polzin, W.J. and Brady, K.: Mechanical factors in the etiology of premature rupture of the membranes. Clin. Obstet. Gynecol. 34, 702 (1991).CrossRefGoogle ScholarPubMed
6Oyen, M.L., Calvin, S.E. and Cook, R.F.: Uniaxial stress-relaxation and stress-strain responses of human amnion. J. Mater. Sci.-Mater. Med. 15, 619 (2004).CrossRefGoogle ScholarPubMed
7Helmig, R., Oxlund, H., Petersen, L.K. and Uldbjerg, N.: Different biomechanical properties of human fetal membranes obtained before and after delivery. Eur. J. Obstet. Gynecol. Reprod. Biol. 48, 183 (1993).CrossRefGoogle ScholarPubMed
8Lavery, J.P. and Miller, C.E.: The effect of labor on the rheologic response of chorioamniotic membranes. Obstet. Gynecol. 50, 467 (1977).Google Scholar
9Lavery, J.P., Miller, C.E. and Knight, R.D.: The effect of labor on the rheologic response of chorioamniotic membranes. Obstet. Gynecol. 60, 87 (1982).Google ScholarPubMed
10Oyen, M.L., Cook, R.F. and Calvin, S.E.: Mechanical failure of human fetal membrane tissues. J. Mater. Sci.-Mater. Med. 15, 651 (2004).CrossRefGoogle ScholarPubMed
11Schober, E.A., Kusy, R.P. and Savitz, D.A.: Resistance of fetal membranes to concentrated force applications and reconciliation of puncture and burst testing. Ann. Biomed. Eng. 22, 540 (1994).CrossRefGoogle ScholarPubMed
12Pressman, E.K., Cavanaugh, J.L. and Woods, J.R.: Physical properties of the chorioamnion throughout gestation. Am. J. Obstet. Gynecol. 187, 672 (2002).CrossRefGoogle ScholarPubMed
13Findley, W.N., Lai, J. and Onaran, K.: Creep and Relaxation of Nonlinear Viscoelastic Materials (Dover, New York, 1989).Google Scholar
14Fung, Y.C.: Biomechanics: Mechanical Properties of Living Tissues , 2nd ed. (Springer-Verlag, New York, 1993).CrossRefGoogle Scholar
15Oyen-Tiesma, M. and Cook, R.F.: Technique for estimating the fracture resistance of cultured neocartilage. J. Mater. Sci.-Mater. Med. 12, 327 (2001).CrossRefGoogle ScholarPubMed
16Haut, R.C. and Little, R.W.: A constitutive equation for collagen fibers. J. Biomech. 5, 423 (1972).CrossRefGoogle ScholarPubMed
17Toppozada, M.K., Sallam, N.A., Gaafar, A.A. and el-Kashlan, K.M.: Role of repeated stretching in the mechanism of timely rupture of the membranes. Am. J. Obstet. Gynecol. 108, 243 (1970).CrossRefGoogle ScholarPubMed
18Dunn, M.G. and Silver, F.H.: Viscoelastic behavior of human connective tissues: Relative contribution of viscous and elastic components. Connect. Tissue Res. 12, 59 (1983).CrossRefGoogle ScholarPubMed
19Oyen-Tiesma, M. and Cook, R.F.: Solution-mediated stress relaxation of an artificial cartilage, in Soc Exper Mech 2001 Annual Meeting Proc, 234–236 (2001).Google Scholar
20Weiner, C.P., Heilskov, J., Pelzer, G., Grant, S., Wenstrom, K. and Williamson, R.A.: Normal values for human umbilical venous and amniotic fluid pressures and their alteration by fetal disease. Am. J. Obstet. Gynecol. 161, 714 (1989).CrossRefGoogle ScholarPubMed
21Harmanli, O.H., Wapner, R.J. and Lontz, J.F.: Efficacy of fibrin glue for in vitro sealing of human chorioamniotic membranes. J. Reprod. Med. 43, 986 (1998).Google ScholarPubMed