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Synthesis of novel core–shell structural AuNR@MCM-41 for infrared light-driven release of drug

Published online by Cambridge University Press:  15 September 2011

Liping Xie ,
Biao Dong ,
Zhenlong Jiang ,
Yu Wang ,
Tong Liu  and
Xue Bai
Liping Xie
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Biao Dong*
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Zhenlong Jiang
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Yu Wang
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Tong Liu
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Xue Bai
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

The hexagonal mesoporous silica MCM-41 nanospheres with Au nanorods (AuNRs) as core have been synthesized via a modified Stöber method by a process of hydration and condensation of tetraethoxysilane in a water–ethanol mixture. The AuNR@MCM-41 nanocomposites combine the photothermal characteristic with the mesopore of MCM-41 in one body. We utilized these core–shell materials for ibuprofen encapsulation and release in the simulated body fluid (pH 7.4) for the first time. The results certificated AuNR@MCM-41 nanocomposites as novel dual-functional materials could realize the light-driven release of drug due to the photothermal effect of the AuNRs. Such novel nanomaterials offer a new way for cancer treatment which combine hyperthermia with the chemotherapeutic drugs by synergistic effect.

Keywords

BiomaterialCompositeCore/shell
Type
Articles
Information
Journal of Materials Research , Volume 26 , Issue 18 , 28 September 2011 , pp. 2414 - 2419
Copyright
Copyright © Materials Research Society 2011

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References

REFERENCES

1.Trewyn, B.G., Giri, S., Slowing, I.I., and Lin, V.S.Y.: Mesoporous silica nanoparticle based controlled release, drug delivery, and biosensor systems. Chem. Commun. 31, 3236 (2007).Google Scholar
2.Smith, A.M., Duan, H., Mohs, A.M., and Nie, S.: Bioconjugated quantum dots for in vivo molecular and cellular imaging. Adv. Drug Delivery Rev. 60, 1226 (2008).Google Scholar
3.McCarthy, J.R. and Weissleder, R.: Multifunctional magnetic nanoparticles for targeted imaging and therapy. Adv. Drug Delivery Rev. 60, 1241 (2008).CrossRefGoogle ScholarPubMed
4.Park, K., Lee, S., Kang, E., Kim, K., Choi, K., and Kwon, I.C.: New generation of multifunctional nanoparticles for cancer imaging and therapy. Adv. Funct. Mater. 19, 1553 (2009).Google Scholar
5.Maschmeyer, T., Rey, F., Sankar, G., and Thomas, J.M.: Heterogeneous catalysts obtained by grafting metallocene complexes onto mesoporous silica. Nature 378, 159 (1995).CrossRefGoogle Scholar
6.Corma, A.: From microporous to mesoporous molecular sieve materials and their use in catalysis. Chem. Rev. 97, 2373 (1997).CrossRefGoogle ScholarPubMed
7.Corma, A., Galletero, M.S., Garcia, H., Palomares, E., and Rey, F.: Pyrene covalently anchored on a large external surface area zeolite as a selective heterogeneous sensor for iodide. Chem. Commun.. 2, 1100 (2002).CrossRefGoogle Scholar
8.Nguyen, T., Wu, J., Doan, V., Schwartz, B.J., and Tolbert, S.H.: Control of energy transfer in oriented conjugated polymer-mesoporous silica composites. Science 288, 652 (2000).CrossRefGoogle ScholarPubMed
9.Hernandez, R., Tseng, H., Wong, J.W., Stoddart, J.F., and Zink, J.I.: An operational supramolecular nanovalve. J. Am. Chem. Soc. 126, 3370 (2004).CrossRefGoogle ScholarPubMed
10.Angelos, S., Yang, Y., Patel, K., Stoddart, J.F., and Zink, J.I.: pH-Responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes. Angew. Chem. Int. Ed. 47, 2222 (2008).CrossRefGoogle Scholar
11.Leung, K.C.F., Nguyen, T.D., Stoddart, J.F., and Zink, J.I.: Supramolecular nanovalves controlled by proton abstraction and competitive binding. Chem. Mater. 18, 5919 (2006).CrossRefGoogle Scholar
12.Ferris, D.P., Zhao, Y., Khashab, N.M., Khatib, H.A., Stoddart, J.F., and Zink, J.I.: Light-operated mechanized nanoparticles. J. Am. Chem. Soc. 131, 1686 (2009).Google Scholar
13.Lai, C., Trewyn, B.G., Jeftinija, D.M., Jeftinija, K., Xu, S., Jeftinija, S., and Lin, V.S.Y.: A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules. J. Am. Chem. Soc. 125, 4451 (2003).CrossRefGoogle ScholarPubMed
14.Mal, N.K., Fujiwara, M., and Tanaka, Y.: Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica. Nature 421, 350 (2003).CrossRefGoogle ScholarPubMed
15.Weissleder, R.: A clearer vision for in vivo imaging. Nat. Biotechnol. 19, 316 (2001).Google Scholar
16.Link, S. and El-Sayed, M.A.: Shape and size dependence of radiative, non-radiative and photothermal properties of gold nanocrystals. Int. Rev. Phys. Chem. 19, 409 (2000).CrossRefGoogle Scholar
17.Huang, X., El-Sayed, I.H., Qian, W., and El-Sayed, M.A.: Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J. Am. Chem. Soc. 128, 2115 (2006).CrossRefGoogle ScholarPubMed
18.Kim, C., Ghosh, P., and Rotello, V.M.: Multimodal drug delivery using gold nanoparticles. Nanoscale 1, 61 (2009).Google Scholar
19.Kim, C.K., Ghosh, P., Pagliuca, C., Zhu, Z., Menichetti, S., and Rotello, V.M.: Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells. J. Am. Chem. Soc. 131, 1360 (2009).CrossRefGoogle ScholarPubMed
20.Stober, W., Fink, A., and Bohn, E.: Controlled growth of monodisperse silica spheres in the micron size range. J. Colloid Interface Sci. 26, 62 (1968).CrossRefGoogle Scholar
21.Gorelikov, I. and Matsuura, N.: Single-step coating of mesoporous silica on cetyltrimethyl ammonium bromide-capped nanoparticles. Nano Lett. 8, 369 (2008).Google Scholar
22.Murphy, C.J., Sau, T.K., Gole, A.M., Orendorff, C.J., Gao, J., Gou, L., Hunyadi, S.E., and Li, T.: Anisotropic metal nanoparticles: Synthesis, assembly, and optical applications. J. Phys. Chem. B 109, 13857 (2005).Google Scholar
23.Murphy, C.J., Gole, A.M., Hunyadi, S.E., and Orendorff, C.J.: One-dimensional colloidal gold and silver nanostructures. Inorg. Chem. 45, 7544 (2006).CrossRefGoogle ScholarPubMed
24.Yano, K. and Fukushima, Y.: Particle size control of mono-dispersed super-microporous silica spheres. J. Mater. Chem. 13, 2577 (2003).Google Scholar
25.Cong, H., Toftegaard, R., Arnbjerg, J., and Ogilby, P.R.: Silica-coated gold nanorods with a gold overcoat: Controlling optical properties by controlling the dimensions of a gold−silica−gold layered nanoparticle. Langmuir 26, 4188 (2010).Google Scholar
26.Link, S. and El-Sayed, M.A.: Spectral properties and relaxation dynamics of surface plasmon electronic oscillations in gold and silver nanodots and nanorods. J. Phys. Chem. B 103, 8410 (1999).CrossRefGoogle Scholar
27.Andersson, J., Rosenholm, J., Areva, S., and Linden, M.: Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro- and mesoporous silica matrices. Chem. Mater. 16, 4160 (2004).CrossRefGoogle Scholar
28.Vallet-Regi, M., Ramila, A., Del Real, R.P., and Perez-Pariente, J.: A new property of MCM-41: Drug delivery system. Chem. Mater. 13, 308 (2001).CrossRefGoogle Scholar