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Preparation and characteristics of novel poly-L-lactide/β-calcium metaphosphate fracture fixation composite rods

Published online by Cambridge University Press:  31 January 2011

Li Liao ,
Lin Chen ,
Ai-Zheng Chen ,
Xi-Ming Pu ,
Yun-Qing Kang ,
Ya-Dong Yao ,
Xiao-Ming Liao ,
Zhong-bing Huang  and
Guang-Fu Yin
Li Liao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Lin Chen
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Ai-Zheng Chen
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Xi-Ming Pu
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Yun-Qing Kang
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Ya-Dong Yao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Xiao-Ming Liao
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Zhong-bing Huang
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
Guang-Fu Yin*
Affiliation:
School of Materials Science and Engineering, Sichuan University, Chengdu 610064, Sichuan Province, People’s Republic of China
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

A kind of novel poly-L-lactide (PLLA)/β-calcium metaphosphate (β-CMP) fracture-fixation composite rod was prepared by a two-step compression-molding method. The in vitro bioactivity of the composite rod was evaluated by investigating the effects of dissolved products from the composite rod on osteoblasts. In addition, the in vitro biocompatibility of the composite rod was evaluated by an osteoblast adhesion-and-proliferation assay. The products from composite rod dissolution significantly promoted cell growth. Furthermore, osteoblasts adhered and spread well on the rod. This PLLA/β-CMP composite rod has potential applications for clinical use following the assessment of adaptation during in vivo studies.

Keywords

CMPCompositeStrength
Type
Articles
Information
Journal of Materials Research , Volume 22 , Issue 12 , December 2007 , pp. 3324 - 3329
Copyright
Copyright © Materials Research Society 2007

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