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Investigating the effects of surface-initiated polymerization of ε-caprolactone to bioactive glass particles on the mechanical properties of settable polymer/ceramic composites

Published online by Cambridge University Press:  18 September 2014

Andrew J. Harmata ,
Catherine L. Ward ,
Katarzyna J. Zienkiewicz ,
Joseph C. Wenke  and
Scott A. Guelcher Open the ORCID record for Scott A. Guelcher [Opens in a new window]
Andrew J. Harmata
Affiliation:
Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA; and Center for Bone Biology, Vanderbilt Medical Center, Nashville, TN 37232, USA
Catherine L. Ward
Affiliation:
Orthopaedic Task Area, U.S. Army Institute of Surgical Research, San Antonio, TX 78234, USA
Katarzyna J. Zienkiewicz
Affiliation:
Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA
Joseph C. Wenke
Affiliation:
Orthopaedic Task Area, U.S. Army Institute of Surgical Research, San Antonio, TX 78234, USA
Scott A. Guelcher*
Affiliation:
Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37235, USA; Center for Bone Biology, Vanderbilt Medical Center, Nashville, TN 37232, USA; and Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Injectable bone grafts with strength exceeding that of trabecular bone could improve the clinical management of a number of orthopedic conditions. Ceramic/polymer composites have been investigated as weight-bearing bone grafts, but they are typically weaker than trabecular bone due to poor interfacial bonding. We hypothesized that entrapment of surface-initiated poly(ε-caprolactone) (PCL) chains on 45S5 bioactive glass (BG) particles within an in situ-formed polymer network would enhance the mechanical properties of reactive BG/polymer composites. When the surface-initiated PCL molecular weight exceeded the molecular weight between crosslinks of the network, the compressive strength of the composites increased 6- to 10-fold. The torsional strength of the composites exceeded that of human trabecular bone by a factor of two. When injected into femoral condyle defects in rats, the composites supported new bone formation at 8 weeks. The initial bone-like strength of BG/polymer composites and their ability to remodel in vivo highlight their potential for development as injectable grafts for repair of weight-bearing bone defects.

Keywords

surface chemistrycompositepolymer
Type
Invited Feature Papers
Information
Journal of Materials Research , Volume 29 , Issue 20 , 28 October 2014 , pp. 2398 - 2407
Copyright
Copyright © Materials Research Society 2014 

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Footnotes

This paper has been selected as an Invited Feature Paper.

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