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Influence of Tricalcium Aluminate Phase on In Vitro Biocompatibility and Bioactivity of Calcium Aluminate Bone Cement

Published online by Cambridge University Press:  03 March 2011

S.H. Oh ,
R. Finones ,
S. Jin ,
S.Y. Choi  and
K.N. Kim
S.H. Oh
Affiliation:
Materials Sciences and Engineering Program, Department of Mechanical Aerospace Engineering, University of California at San Diego, La Jolla, California, 92093
R. Finones
Affiliation:
Materials Sciences and Engineering Program, Department of Mechanical Aerospace Engineering, University of California at San Diego, La Jolla, California, 92093
S. Jin*
Affiliation:
Materials Sciences and Engineering Program, Department of Mechanical Aerospace Engineering, University of California at San Diego, La Jolla, California, 92093
S.Y. Choi
Affiliation:
Department of Ceramic Engineering, Yonsei University, Seoul 120-749, Korea
K.N. Kim
Affiliation:
Department of Biomaterials and Bioengineering, Yonsei University, Seoul 120-752, Korea
*
a)Address all correspondence to this author. e-mail: [email protected].This author was an editor of this journal during the review and decision stage. For the JMR policy on review and publication of manuscripts authored by editors, please refer to http://www.mrs.org/publications/jmr/policy.html.
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Abstract

The influence of tricalcium aluminate (3CaO·Al2O3) phase doping on in vitro biocompatibility and bioactivity of calcium aluminate (CaO·Al2O3) based bone cement has been investigated. It is demonstrated that the presence of approximately 25% tricalcium aluminate in the bone cement remarkably improves the bioactivity, yet still retains desirable mechanical strength and biocompatibility. An intermediary compound layer such as Ca3Al2(OH)12 was formed on the surface of the doped sample onto which hydroxyapatite (HAp) began to form soon, after only 2 days of immersion in a simulated body fluid solution. This is about seven-fold acceleration in the HAp formation over undoped calcium aluminate cement on which it took approximately15 days to nucleate the HAp phase. The depth of the HAp-containing layer after60 days of soaking was as much as 85 μm, about an order of magnitude more than the undoped calcium aluminate cement. The dramatically accelerated nucleation and growth of hydroxyapatite caused by the presence of tricalcium aluminate is attributed to the occurrence of intermediate layer materials such as Ca3Al2(OH)12, which most likely acts as the nuclei for HAp formation. This doped bone cement can be useful for injectable orthopedic applications, as the setting time for hardening has also been significantly reduced (by a factor of at least 4) to a practical regime of tens of minutes.

Keywords

Bone cementBiocompatibilityBioactivity
Type
Articles
Information
Journal of Materials Research , Volume 19 , Issue 4 , April 2004 , pp. 1062 - 1067
Copyright
Copyright © Materials Research Society 2004

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