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Degradation of PGA, prepared by reactive extrusion polymerization, in water, humid, and dry air, and in a vacuum

Published online by Cambridge University Press:  22 July 2020

Shuliang Chen Open the ORCID record for Shuliang Chen [Opens in a new window] ,
Xin Zhang ,
Mingyang He  and
Jinchun Li
Shuliang Chen
Affiliation:
School of Materials Science and Engineering, Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Changzhou University, Changzhou213164, China
Xin Zhang
Affiliation:
College of Petrochemical Engineering, Jiangsu Key Laboratory of Green Catalytic Materials and Technology, Changzhou University, Changzhou213164, China
Mingyang He
Affiliation:
College of Petrochemical Engineering, Jiangsu Key Laboratory of Green Catalytic Materials and Technology, Changzhou University, Changzhou213164, China
Jinchun Li*
Affiliation:
School of Materials Science and Engineering, Jiangsu Key Laboratory of Environmentally Friendly Polymeric Materials, Changzhou University, Changzhou213164, China
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Polyglycolide (PGA) materials have been widely used in the medical field, but the degradation mechanism in the natural environment is still unclear. High-viscosity PGA was prepared by using twin-screw reaction extrusion polymerization. The mass and intrinsic viscosity of PGA samples, the pH of the solution surrounding the PGA samples in water, and the number of degradation products resulting from the degradation of the PGA samples were studied under different conditions and at different temperatures. PGA does not degrade at 70 °C in either dry air or in a vacuum. Infrared spectroscopy (FTIR) and differential spectroscopy revealed that the PGA samples in water at 70 °C for 40 days had a substantially reduced mass and substantially altered thermal behavior when compared with the control sample (undegraded PGA sample). The degradation of the PGA samples in humid conditions at 70 °C was similar to the degradation of the samples in water at 70 °C. The results of this study indicate that water and water vapor (moisture) in the natural environment are the main causes of PGA degradation, and higher temperatures accelerate the degradation process, which shortens the shelf life and life of PGA.

Keywords

polyglycolidedegradationwater environment
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 14 , 28 July 2020 , pp. 1846 - 1856
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Copyright
Copyright © Materials Research Society 2020

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