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Amino acid–intercalated layered double hydroxide core @ ordered porous silica shell as drug carriers: Design and applications

Published online by Cambridge University Press:  07 November 2019

Jianqiang Wang Open the ORCID record for Jianqiang Wang [Opens in a new window] ,
Wenpei Zhang ,
Lifeng Hao ,
Jun Sun ,
Wenqi Zhang ,
Cheng Guo ,
Yuhan Mu ,
Weiting Ji ,
Caiyuan Yu  and
Fangming Yuan
Jianqiang Wang*
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Wenpei Zhang
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Lifeng Hao*
Affiliation:
Department of Engineering, Qiuzhen School, Huzhou University, Huzhou, Zhejiang 313000, China
Jun Sun
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Wenqi Zhang
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Cheng Guo
Affiliation:
School of Chemistry and Molecular Engineering, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Yuhan Mu
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Weiting Ji
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Caiyuan Yu
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
Fangming Yuan
Affiliation:
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, Jiangsu 211816, China
*
a)Address all correspondence to these authors. e-mail: [email protected]
b)e-mail: [email protected]
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Abstract

A nanoparticle-based drug delivery system is first established by mesoporous silica encapsulating amino acid–intercalated layered double hydroxide (LDH) to construct nanocomposites AA-LDH@MS. The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into LDH as the cores Phe-LDH and His-LDH. These nanocomposites AA-LDH@MS display multispaces of the interlayer spaces of LDH and porous channels of mesoporous silica to load drugs. Moreover, amino acid molecules provide the interaction sites to improve effectively loading amounts of drugs. 5-Fluorouracil (5-FU) is used as the cargo molecules to observe the delivery in vitro. The results indicate that the maximum loading amounts of drugs are up to 392 mg/g at 60 °C for 12 h in the nanocomposite Phe-LDH@MS. All the nanocomposites exhibit the sustained release of 5-FU at pH 4 and pH 7.4. The Korsmeyer–Peppas model is used to fit the kinetic plot of the drug release in vitro, which concludes that 5-FU release from AA-LDH@MS belongs to Fickian diffusion.

Keywords

core–shelldrug deliverylayered double hydroxideamino acidspH responsive
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 22 , 28 November 2019 , pp. 3747 - 3756
Copyright
Copyright © Materials Research Society 2019 

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References

Luo, H.Y., Li, J., and Chen, X.: Antitumor effect of N-succinyl-chitosan nanoparticles on K562 cells. Biomed. Pharmacother. 64, 521 (2010).CrossRefGoogle ScholarPubMed
Torchilin, V.P.: Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery. Nat. Rev. Drug Discovery 13, 813 (2014).CrossRefGoogle ScholarPubMed
Leucuta, S.E.: Nanotechnology for delivery of drugs and biomedical applications. Curr. Clin. Pharmacol. 5, 257 (2010).CrossRefGoogle ScholarPubMed
Ragelle, H., Danhier, F., Préat, V., Langer, R., and Anderson, D.G.: Nanoparticle-based drug delivery systems: A commercial and regulatory outlook as the field matures. Expert Opin. Drug Delivery 14, 851 (2017).CrossRefGoogle ScholarPubMed
Alvarez-Lorenzo, C., Blanco-Fernandez, B., Puga, A.M., and Concheiro, A.: Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery. Adv. Drug Delivery Rev. 65, 1148 (2013).CrossRefGoogle ScholarPubMed
Jia, W., Kui, Y., Liu, F.Y., Li, H.J., Xu, Y.Q., and Sun, S.G.: Diverse gatekeepers for mesoporous silica nanoparticle based drug delivery systems. Chem. Soc. Rev. 46, 6024 (2017).Google Scholar
Tatsuya, M. and Kunihiro, T.: Recent advances in inorganic nanoparticle-based drug delivery systems. Mini-Rev. Med. Chem. 8, 175 (2008).Google Scholar
Biju, V.: Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery, and therapy. Chem. Soc. Rev. 43, 744 (2014).CrossRefGoogle ScholarPubMed
Singh, R. and Lillard, J.W. Jr.: Nanoparticle-based targeted drug delivery. Exp. Mol. Pathol. 86, 215 (2009).CrossRefGoogle ScholarPubMed
Chen, G., Roy, I., Yang, C., and Prasad, P.N.: Nanochemistry and nanomedicine for nanoparticlebased diagnostics and therapy. Chem. Rev. 116, 2826 (2016).CrossRefGoogle Scholar
Bi, X., Zhang, H., and Dou, L.G.: Layered double hydroxide-based nanocarriers for drug delivery. Pharmaceutics 6, 298 (2014).CrossRefGoogle ScholarPubMed
Rives, V., Arco, M., and Martín, C.: Layered double hydroxides as drug carriers and for controlled release of non-steroidal antiinflammatory drugs (NSAIDs): A review. J. Controlled Release 169, 28 (2013).CrossRefGoogle ScholarPubMed
Ma, X., Feng, H.H., Liang, C.Y., Liu, X.J., Zeng, F.Y., and Wang, Y.: Mesoporous silica as micro/nano-carrier: From passive to active cargo delivery, a mini review. J. Mater. Sci. Technol. 33, 1067 (2017).CrossRefGoogle Scholar
Li, Z., Barnes, J.C., Bosoy, A., Stoddart, J.F., and Zink, J.I.: Mesoporous silica nanoparticles in biomedical applications. Chem. Soc. Rev. 41, 2590 (2012).CrossRefGoogle ScholarPubMed
Tronto, J., Cardoso, L.P., Valim, J.B., Marchetti, J.M., Vitória, M., and Bentley, B.: Studies of the intercalation and “in vitro” liberation of amino acids in magnesium aluminium layered double hydroxides. Mol. Cryst. Liq. Cryst. 309, 79 (2003).CrossRefGoogle Scholar
Kriven, W.M., Kwak, S.Y., Wallig, M.A., and Choy, J.H.: Bio-resorbable nanoceramics for gene and drug delivery. MRS Bull. 29, 33 (2004).CrossRefGoogle Scholar
Kwak, S.Y., Kriven, W.M., Wallig, M.A., and Choy, J.H.: Inorganic delivery vector for intravenous injection. Biomaterials 25, 5995 (2004).CrossRefGoogle ScholarPubMed
Bao, H.F., Yang, J.P., Huang, Y., Xu, Z.P., Hao, N., Wu, Z.X., (Max) Lu, G.Q., and Zhao, D.Y.: Synthesis of well-dispersed layered double hydroxide core@ordered mesoporous silica shell nanostructure (LDH@mSiO2) and its application in drug delivery. Nanoscale 3, 4069 (2011).CrossRefGoogle Scholar
Vyskočilová, E., Luštická, I., Paterová, I., Machová, L., and Červený, L.: Modified MCM-41 as a drug delivery system for acetylsalicylic acid. Solid State Sci. 38, 85 (2014).CrossRefGoogle Scholar
Mathew, A., Parambadath, S., Park, S.S., and Ha, C.S.: Hydrophobically modified spherical MCM-41 as nanovalve system for controlled drug delivery. Microporous Mesoporous Mater. 200, 124 (2014).CrossRefGoogle Scholar
Vallet-Regi, M., Ramila, A., del Real, R.P., and Perez-Pariente, J.: A new property of MCM-41: Drug delivery system. Chem. Mater. 13, 308 (2001).CrossRefGoogle Scholar
Liu, J., Harrison, R., Zhou, J.Z., Li, T.T., Yu, C.Z., (Max) Lu, G.Q., Qiao, S.Z., and Xu, Z.P.: Synthesis of nanorattles with layered double hydroxide core and mesoporous silica shell as delivery vehicles. J. Mater. Chem. 21, 10641 (2011).CrossRefGoogle Scholar
Barnabas, M.J., Parambadath, S., and Ha, C.: Amino modified core–shell mesoporous silica based layered double hydroxide (MS-LDH) for drug delivery. J. Ind. Eng. Chem. 53, 392 (2017).CrossRefGoogle Scholar
Aisawa, S., Sasaki, S., Takahashi, S., Hirahara, H., Nakayama, H., and Narita, E.: Intercalation of amino acids and oligopeptides into Zn–Al layered double hydroxide by coprecipitation reaction. J. Phys. Chem. Solids 67, 920 (2006).CrossRefGoogle Scholar
Lampman, G.M., Pavia, D.L., Kriz, G.S., and Vyvyan, J.R.: Spectroscopy, 4th ed. (Brooks/Cole, Belmont, 2009); pp. 80–83.Google Scholar
Veteška, M., Pospíšil, M., Melánová, K., Beneš, L., and Zima, V.: Structure analysis of hydrotalcite intercalated with pyrenetetrasulfonate; experiments and molecular modelling. J. Mol. Model. 14, 1119 (2008).CrossRefGoogle ScholarPubMed
Shoaib, M.H., Tazeen, J., Merchant, H.A., and Yousuf, R.I.: Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak. J. Pharm. Sci. 19, 119 (2006).Google ScholarPubMed
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