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Compare IOM, Assessing Genomic Sequencing, supra note 40, at 7 (“Exome sequencing can be used for either clinical or research purposes, though recently the boundaries between the two have been blurring. In Hegde's laboratory, exome data are divided according to why the sequencing is being done. For new disease presentations the diagnostic yield, or likelihood that the test will provide enough information to make an appropriate diagnosis, ranges roughly from 30 percent to 40 percent, depending on which laboratory is reporting and what kinds of cases are considered, Hegde said. When writing clinical reports, she said, it is critical to sorting the data into categories of what can be interpreted in the clinic and what is clinically actionable….”).Google Scholar

Author, S. M. W. thanks Hank Greely for early conversation on this point.Google Scholar

See, e.g., Callahan, D. Jennings, B., “Ethics and Public Health: Forging a Strong Relationship,” American Journal of Public Health 92, no. 2 (2002): 169–176; Kass, N. E., “An Ethics Framework for Public Health,” American Journal of Public Health 91, no. 11 (2001): 1776–1782.CrossRefGoogle Scholar

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Khoury, et al. , “Knowledge Integration,” supra note 25.Google Scholar

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See sources cited and discussed in id.Google Scholar