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Antibiotic Resistance Spreads Internationally Across Borders

Published online by Cambridge University Press:  01 January 2021

Tamar F. Barlam  and
Kalpana Gupta
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Extract

Antibiotic resistance (ABR) poses an urgent public health risk. High rates of ABR have been noted in all regions of the globe by the World Health Organization. ABR develops when bacteria are exposed to antibiotics either during treatments in humans or animals or through environmental sources contaminated with antibiotic residues (Figure, Panel A). Spread beyond those administered antibiotics occurs through direct contact with the infected or colonized person or animal, through contact or ingestion of retail meat or agricultural products contaminated with ABR organisms, or through the environment. ABR bacteria spread from individuals to populations and across countries (Figure, Panel B).

Type
JLME Supplement
Information
Journal of Law, Medicine & Ethics , Volume 43 , Issue S3 , Autumn 2015 , pp. 12 - 16
Copyright
Copyright © American Society of Law, Medicine and Ethics 2015

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References

World Health Organization, Antibiotic Resistance: Global Report on Surveillance (2014), available at <http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf> (last visited May 8, 2015).+(last+visited+May+8,+2015).>Google Scholar
Centers for Disease Control and Prevention (CDC), “Antibiotic Resistance Threats in the United States. 2013,” available at <http://www.cdc.gov/drugresistance/threat-report-2013/> (last visited May 8, 2015).+(last+visited+May+8,+2015).>Google Scholar
Gerding, D. N. Lessa, F. C., “The Epidemiology of Clostridium difficile Infection Inside and Outside Health Care Institutions,” Infectious Disease Clinics of North America 29, no. 1 (2015): 37–50.CrossRefGoogle Scholar
He, M. et al., “Emergence and Global Spread of Epidemic Healthcare-Associated Clostridium Difficile,” Nature Genetics 45, no. 1 (2013): 109–113.CrossRefGoogle Scholar
Yong, D. et al., “Characterization of a New Metallo- -Lactamase Gene, blaNDM-1, and a Novel Erythromycin Esterase Gene Carried on a Unique Genetic Structure in Klebsiella Pneumoniae Sequence Type 14 from India,” Antibiotic Agents and Chemotherapy 53, no. 12 (2009): 5046–5054.CrossRefGoogle Scholar
Johnson, A. P. Woodford, N., “Global Spread of Antibiotic Resistance: The Example of New Delhi Metallo-b-Lactamase (NDM)-Mediated Carbapenem Resistance,” Journal of Medical Microbiology 62, part 4 (2013): 499–513.CrossRefGoogle Scholar
Molton, J. S. et al., “The Global Spread of Healthcare-Associated Multidrug-Resistant Bacteria: A Perspective from Asia,” Clinical Infectious Diseases 56, no. 9 (2013): 1310–1318.Google Scholar
Rogers, B. A. et al., “Country-to-Country Transfer of Patients and the Risk of Multi-Resistant Bacterial Infection,” Clinical Infectious Diseases 53, no. 1 (2011): 49–56.CrossRefGoogle Scholar
Yong, D. et al., “Epidemiological Characteristics and Molecular Basis of Fluoroquinolone-Resistant Neisseria Gonorrhoeae Strains Isolated in Korea and Nearby Countries,” Journal of Antibiotic Chemotherapy 54, no. 2 (2004): 451–455; Pérez-Losada, M. et al., “Distinguishing Importation from Diversification of Quinolone-Resistant Neisseria Gonorrhoeae by Molecular Evolutionary Analysis,” BMC Evolutionary Biology 7, article 84 (2007).CrossRefGoogle Scholar
Aarestrup, F. M. et al., “Resistance in Bacteria of the Food Chain: Epidemiology and Control Strategies,” Expert Review of Anti-Infective Therapy 6, no. 5 (2008): 733–750.CrossRefGoogle Scholar
Abgottspon, H. et al., “Characteristics of Extended-Spectrum Cephalosporin-Resistant Escherichia coli Isolated from Swiss and Imported Poultry Meat,” Journal of Food Protection 77, no. 1 (2014): 112–115.CrossRefGoogle Scholar
Warren, R. E. et al., “Imported Chicken Meat as a Potential Source of Quinolone-Resistant Escherichia coli Producing Extended-Spectrum Beta-Lactamases in the UK,” Journal of Antibiotic Chemotherapy 61, no. 3 (2008): 504–508.CrossRefGoogle Scholar
Lazarus, B. et al., “Do Human Extra Intestinal Escherichia coli Infections Resistant to Expanded-Spectrum Cephalosporins Originate from Food-Producing Animals? A Systematic Review,” Clinical Infectious Diseases 60, no. 3 (2015): 439–452.CrossRefGoogle Scholar
Hummel, R. et al., “Spread of Plasmid-Mediated Nourseothricin Resistance Due to Antibiotic Use in Animal Husbandry,” Journal of Basic Microbiology 26, no. 8 (1986): 461–466.CrossRefGoogle Scholar
Hammerum, A. M. et al., “Characterization of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli Obtained from Danish Pigs, Pig Farmers and Their Families from Farms with High or No Consumption of Third- or Fourth-Generation Cephalosporins,” Journal of Antibiotic Chemotherapy 69, no. 10 (2014): 2650–2657.CrossRefGoogle Scholar
Amos, G. C. A. et al., “Waste Water Effluent Contributes to the Dissemination of CTX-M-15 in the Natural Environment,” Journal of Antibiotic Chemotherapy 69, no. 7 (2014): 1785–1791.Google Scholar
Andersson, D. I. Hughes, D., “Microbiological Effects of Sublethal Levels of Antibiotics,” Nature Reviews Microbiology 12, no. 7 (2014): 465–478.CrossRefGoogle Scholar
Graham, J. P. et al., “Antibiotic Resistant Enterococci and Staphylococci Isolated from Flies Collected Near Confined Poultry Feeding Operations,” Science of the Total Environment 407, no. 8 (2009): 2701–2710.CrossRefGoogle Scholar
Hamscher, G. et al., “Antibiotics in Dust Originating from a Pig-Fattening Farm: A New Source of Health Hazard for Farmers?” Environmental Health Perspectives 111, no. 13 (2003): 1590–1594.CrossRefGoogle Scholar
See Andersson, Hughes, , supra note 17.Google Scholar
Snitkin, E. S. et al., “Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing,” Science Translational Medicine 4, no.148 (2012): 148ra116.CrossRefGoogle Scholar
Lübbert, C. et al., “Colonization with Extended-Spectrum Beta-Lactamase-Producing and Carbapenemase-Producing Enterobacteriaceae in International Travelers Returning to Germany,” International Journal of Medical Microbiology 305, no. 1 (2015): 148–156.CrossRefGoogle Scholar
Von Wintersdorff, C. J. et al., “High Rates of Antibiotic Drug Resistance Gene Acquisition after International Travel, The Netherlands,” Emerging Infectious Diseases 20, no. 4 (2014): 649–657.CrossRefGoogle Scholar
Zhou, Y. P. et al., “The Role of International Travel in the Spread of Methicillin-Resistant Staphylococcus aureus,” Journal of Travel Medicine 21, no. 4 (2014): 272–281.CrossRefGoogle Scholar
Andersson, D. I. Hughes, D., “Antibiotic Resistance and Its Cost: Is It Possible to Reverse Resistance?” Nature Reviews Microbiology 8, no. 4 (2010): 260–271.CrossRefGoogle Scholar