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About Face: Forensic Genetic Testing for Race and Visible Traits

Published online by Cambridge University Press:  01 January 2021

Extract

“DNAPrint Genomics, Inc. has applied the most recent advancements in human genomic technology for the deciphering of an individual's race. We are proud to introduce to the forensic community DNA WITNESS 2.0, a genetic test for the deduction of the heritable component of race, called Biogeographical Ancestry (BGA).”

–Z. Gaskin

“One definite and obvious consequence of the complexity of human demographic history is that races in any meaningful sense of the term do not exist in the human species.”

–D. B. Goldstein and L. Chikhi

Type
Symposium
Copyright
Copyright © American Society of Law, Medicine and Ethics 2006

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References

Gaskin, Z., “Determining Race Proportions from Crime Scene DNA,” DNAPrint Genetics, available at <http://www.bioforensics.com/conference04/Racial_Identification/> (last visited March 8, 2006).+(last+visited+March+8,+2006).>Google Scholar
Goldstein, D. B. and Chikhi, L., “Human Migrations and Population Structure: What We Know and Why It Matters,” in Lander, E. S. Page, D. et al., eds., Annual Review of Genomics and Human Genetics, vol. 3 (Palo Alto: Annual Reviews, 2002): 129152.Google Scholar
Scheck, B. Neufeld, P. and Dwyer, J., Actual Innocence: When Justice Goes Wrong and How to Make It Right (New York: New American Library, 2003): Chapter 1.Google Scholar
The Future of Forensic DNA Testing: Predictions of the Research and Development Working Group, U.S. Department of Justice, National Institute of Justice (2000): at 91; Faigman, D. L. et al., “DNA Typing,” in Faigman, D. L. Kaye, D. H. et al., eds., Science in the Law: Forensic Science Issues (St. Paul: West Group, 2002): 664–761; CODIS website, FBI, available at <http://www.fbi.gov/hq/lab/codis/index1.htm> (last visited March 3, 2006).Google Scholar
The terms “genetic sequence” or “DNA sequence” refer to the ordered arrangement of the four DNA building blocks, or nucleotides, which are often denoted by the initials A, C, G and T. The particular order in which nucleotides are strung together encodes genetic information. The term “DNA structure” describes something more than the nucleotide sequence; it also includes chemical modifications to the DNA, such as the methylation of some nucleotides, and the three-dimensional configuration of the DNA. In some cases, the structure might include proteins that are bound to or associated with the DNA.Google Scholar
Online Mendelian Inheritance in Man, OMIM, McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University (Baltimore, MD) and National Center for Biotechnology Information, National Library of Medicine (Bethesda, MD), available at <http://www.ncbi.nlm.nih.gov/omim/> (last visited March 3, 2006).+(last+visited+March+3,+2006).>Google Scholar
The International HapMap Consortium, “The International Hap-map Project,” Nature 426 (2003): 789796; Hinds, D. A. et al., “Whole-Genome Patterns of Common DNA Variation in Three Human Populations,” Science 307 (2005): 1072–1079; Rosenberg, N. A. et al., “Genetic Structure of Human Populations,” Science 298 (2002): 2381–2385; Reich, D. E. et al., “Linkage Disequilibrium in the Human Genome,” Nature 411 (2001): 199–204.Google Scholar
Barsh, G. S., “What Controls Variation in Human Skin Color,” PLoS Biology 1, no. 1 (2003): 1922; Roh, K. Y. et al., “Pigmentation in Koreans: Study of the Differences from Caucasians in Age, Gender and Seasonal Variations,” British Journal of Dermatology 144 (2001): 94–99; Shriver, M. D. et al., “Skin Pigmentation, Bio-geographical Ancestry and Admixture Mapping,” Human Genetics 112 (2003): 387–399.Google Scholar
“The Future of Forensic DNA Testing,” supra note 4.Google Scholar
von Zglinicki, T. et al., “Human Cell Senescence as a DNA Damage Response,” Mechanisms of Ageing & Development 126, no. 1 (2005): 111117; Wadhwa, R. et al., “Imminent Approaches Towards Molecular Interventions in Ageing,” Mechanisms of Ageing & Development 126, no. 4 (2005): 481–490; Artandi, S. E. and Attardi, L. D., “Pathways Connecting Telomeres and P53 in Senescence, Apoptosis, and Cancer,” Biochemical & Biophysical Research Communications 331, no. 3 (2000): 881–890.CrossRefGoogle Scholar
Bamshad, M. et al., “Deconstructing the Relationship Between Genetics and Race,” Nature Reviews Genetics 5 (2004): 598608; Kittles, R. A. and Weiss, K. M., “Race, Ancestry, and Genes: Implications for Defining Disease Risk,” Annual Review of Genomics and Human Genetics 4 (2003): 33–67; Bonham, V. L. Warshauer-Baker, E. and Collins, F. S., “Race and Ethnicity in the Genome Era: The Complexity of the Constructs,” American Psychologist 60, no. 1 (2005): 9–15.CrossRefGoogle Scholar
Brandt-Rauf, P. W. and Brandt-Rauf, S. I., “Biomarkers – Scientific Advances and Societal Implications,” in Rothstein, M. A., ed., Genetic Secrets: Protecting Privacy and Confidentiality in the Genetic Era (New Haven, London: Yale University Press, 1997): at 511; Jaenisch, R. and Bird, A., “Epigenetic Regulation of Gene Expression: How the Genome Integrates Intrinsic and Environmental Signals,” Nature Genetics Supplement 33 (2003): 245254; Knudsen, L. E. et al., “Genotoxic Damage in Mine Workers Exposed to Diesel Exhaust, and the Effects of Glutathione Transeferase Genotypes,” Mutation Research 583 (2005): 120–132; Sul, D. et al., “DNA Damage in Lymphocytes of Benzene Exposed Workers Correlates with Trans, Trans-Muconic Acids and Breath Benzene Levels,” Mutation Research 582 (2005): 61–70.Google Scholar
King, T. E. et al., “Genetic Signatures of Co-ancestry Within Surnames,” Current Biology 16 (2006): 384388; “The Future of Forensic DNA Testing,” supra note 4, at 25, 65–67.CrossRefGoogle Scholar
Abraham, C., “Molecular Eyewitness: DNA Gets a Human Face,” Toronto Globe and Mail, June 25, 2005: at 6; Anonymous, “Have the Police Hijacked Our DNA?Lancet 362, no. 9388 (2003): 927; Anonymous, “DNA Test Showing Ancestry May Have Helped LA Search,” USA Today, June 6, 2003; Wade, N., “Unusual Use of DNA Aided in Serial Killer Search,” The New York Times, National Edition, June 3, 2003.Google Scholar
Wade, N., supra note 14.Google Scholar
DNAPrint Plays Role in Capture, DNAPrint Genomics, available at <http://www.dnaprint.com/welcome/press/press_news/2003/plays/> (last visited March 07, 2006).+(last+visited+March+07,+2006).>Google Scholar
Abraham, C., “Molecular Eyewitness,” supra note 14.Google Scholar
Collins, F. S., “What We Do and Don't Know About ‘Race,’ ‘Ethnicity,’ Genetics and Health at the Dawn of the Genome Era,” Nature Genetics Supplement 36, no. 11 (2004): S13S15; Burchard, E. G. et al., “The Importance of Race and Ethnic Background in Biomedical Research and Clinical Practice,” New England Journal of Medicine 348, no. 12 (2003): 1170–1175; Cooper, R. S. and Kaufman, J. S., “Race and Hypertension: Science and Nescience,” Hypertension 32 (1998): 813–816; Freeman, H. P., “The Meaning of Race in Science – Considerations for Cancer Research,” Cancer 82, no. 1 (1998): 219–225; Frank, R., “A Reconceptualization of the Role of Biology in Contributing to Race/Ethnic Disparities in Health Outcomes,” Population Research and Policy Review 20 (2001): 441–455; Ossorio, P. and Duster, T., “Race and Genetics: Controversies in Biomedical, Behavioral, and Forensic Sciences,” American Psychologist 60, no. 1 (2005) 115–128; Royal, C. D. and Dunston, G. M., “Changing the Paradigm from ‘Race’ to Human Genome Variation,” Nature Genetics Supplement 36, no. 1 (2004): S5–7; Santos, R. V. and Maio, M. C., “Race, Genomics, Identities and Politics in Contemporary Brazil,” Critique of Anthropology 24, no. 4 (2004): 347–378; Risch, N. et al., “Categorization of Humans in Biomedical Research: Genes, Race and Disease,” Genomebiology 3, no. 7 (2002): 1–12; Kittles, R. A. and Weiss, K. M., supra note 11; Haga, S. B. and Venter, J. C., “FDA Races in the Wrong Direction,” Science 301, no. 5632 (2003): 466–467; Bamshad, M. et al., supra note 11; Goldstein, D. B. and Chikhi, L., supra note 2.CrossRefGoogle Scholar
Evett, I. W. et al., “Statistical Analysis of Data for Three British Ethnic Groups from a New STR Multiplex,” International Journal of Legal Medicine 110, no. 1 (1997): 59; Cho, M. K. and Sankar, P., “Forensic Genetics and Ethical, Legal and Social Implications Beyond the Clinic,” Nature Genetics 36, no. 11 (2004): S8–S11; Sauer, N. J., “Forensic Anthropology and the Concept of Race: If Races Don't Exist, Why are Forensic Anthropologists so Good at Identifying Them?” Social Science and Medicine 34, no. 2 (1992): 107–111; Shriver, M. D. et al., “Ethnic-Affiliation Estimation by Use of Population-Specific Markers,” American Journal of Human Genetics 60 (1997): 957–964; Shriver, M. D., supra note 8; Shriver, M. D. Frudakis, T. and Budowle, B., “Getting Science and Ethics Right in Forensic Genetics,” Nature Genetics 37, no. 5 (2005): 449–450 (response to Cho and Sankar with a Cho and Sankar rebuttal directly following).CrossRefGoogle Scholar
Smedley, A. and Smedley, B. D., “Race as Biology is Fiction, Racism as a Social Problem is Real,” American Psychologist 60, no. 1 (2005): 1625; Ossorio, P. and Duster, T., supra note 18; Haga, S. B. and Venter, J. C., supra note 28.CrossRefGoogle Scholar
Gaskin, Z., supra note 1.Google Scholar
Faigman, D. L., supra note 4.Google Scholar
Because genes encode traits, most trait genetic testing involves analyzing genes. In contrast, non-coding regions are analyzed for thirteen-STR testing.Google Scholar
Higginbotham, E. B., “African-American Women's History and the Metalanguage of Race,” Signs 17, no. 2 (1992): 251274, at 253.CrossRefGoogle Scholar
Statement of the American Sociological Association, The Importance of Collecting Data and Doing Social Scientific Research on Race, American Sociological Association, available at <http://www.asanet.org/governance/racestmt.html> (last visited March 8, 2005); Smedley, A. and Smedley, B. D., supra note 20; Reardon, J., Race to the Finish: Identity and Governance in the Age of Genomics (Princeton: Princeton University Press, 2005); Hong, Y. et al., “Predicting Intergroup Bias: The Interactive Effects of Implicit Theory and Social Identity,” Personality and Social Psychology Bulletin 30, no. 8 (2004): 10351047.Google Scholar
Hong, Y. et al., supra note 25, at 1036.Google Scholar
Smedley, A. and Smedley, B. D., “Race as Biology Is Fiction,” supra note 20; Marks, J., What It Means to Be 98% Chimpanzee (Berkeley, Los Angeles: University of California Press, 2002).Google Scholar
Banton, M., “The Idea of Race,” in Back, L. and Solomon, J., eds., Theories of Race and Racism (New York: Routledge, 2000): 5163; Holt, T., Problem of Race in the Twenty-First Century (Cambridge, MA: Harvard University Press, 2000).Google Scholar
Marks, J., supra note 27; Molnar, S., Human Variation: Races, Types and Ethnic Groups, 4th ed. (Upper Saddle River: Prentice Hall, Inc., 1998).Google Scholar
This argument is not logically valid, because conclusion (3a) is ambiguous and does not follow from premises 1 and 2. A trait may be encoded by a single gene, such that possessing a particular allele of that gene leads to a particular version of the trait, yet more than one allele, or more than one gene, may encode that trait. For instance, suppose allele A of the hypothetical Hair Color gene is a dominant allele, and that anybody who possesses a single copy of allele A will have black hair. It could still be the case that other alleles of the HairColor gene, or alleles of genes other than HairColor, encode black hair. In such situations, knowing that a person possesses allele A would allow an observer to predict that the person would have naturally black hair, but knowing that the person has naturally black hair would not allow the observer to infer that the person possesses allele A. Even when a gene strongly determines a trait, two people may possess the same trait yet not possess the same alleles encoding that trait.Google Scholar
For a contemporary example of the contingency and malleability of race see, Chapelle, D., Racial Draft, The Chapelle Show (2003), available on DVD (representatives of various races hold a draft, analogous to the National Basketball Association draft, in which each race selects and trades racially ambiguous celebrities).Google Scholar
Sauer, N. J., “Forensic Anthropology and the Concept of Race,” supra note 19; Omi, M. and Winant, H., Racial Formation in the United States, 2nd ed. (New York, London: Routledge, 1994); Smedley, A., Race in North America: Origin and Evolution of a Worldview, 2nd ed. (Boulder, CO: Westview Press, 1999); Lee, S. Mountain, J. L. and Koenig, B. A., “The Meanings of ‘Race’ in the New Genomics: Implications for Health Disparities Research,” Yale Journal of Health Policy, Law, and Ethics 12 (2001): 3375; Lopez, I. H., “The Social Construction of Race: Some Observations on Illusion, Fabrication, and Choice,” Harvard Civil Rights-Civil Liberties Law Review 29 (1994): 1–62; Lopez, I. H., White by Law (New York and London: New York University Press, 1996); ASA Statement on Race in Research, supra note 25.Google Scholar
ASA Statement on Race in Research, supra note 25; Wang, V. O. and Sue, S., “In the Eye of the Storm: Race and Genomics in Research and Practice,” American Psychologist 60, no. 1 (2005): 3745.Google Scholar
Genetic variation is only one form of biological variation. Many kinds of biological variation are neither determined by nor reducible to genetic variation. Some biological variation may correlate with race yet not be caused by genetic variation. Many health disparities probably fall into this category.Google Scholar
Collins, F. S. et al., “A Vision for the Future of Genomics Research,” Nature 422 (2003): 835847.CrossRefGoogle Scholar
Jorde, L. B. and Wooding, S. P., “Genetic Variation, Classification and ‘Race’,” Nature Genetics Supplement 36, no. 1 (2004): S2833; Marks, J., supra note 27; Kittles, R. A. and Weiss, K. M., supra note 11.CrossRefGoogle Scholar
Jorde, L. B. Carey, J. C. and White, R. L., Medical Genetics (St. Louis: Mosby, 1995); Bonham, V. L. Warshauer-Baker, E. and Collins, F. S., supra note 11.Google Scholar
Marks, J., supra note 27; Olson, S., Mapping Human History: Discovering the Past Through Our Genes (New York: Houghton Mifflin Co., 2002); Kittles, R. A. and Weiss, K. M., “Race, Ancestry, and Genes,” supra note 11; Jorde, L. B. Bamshad, M. and Rogers, A. R., “Using Mitochondrial and Nuclear DNA Markers to Reconstruct Human Evolution,” BioEssays 20, no. 2 (1998): 126136.Google Scholar
Harpending, H. C. et al., “Genetic Traces of Ancient Demography,” Proceedings of the National Academy of Sciences 95 (1998): 19611967; Jorde, L. B. et al., “Microsatellite Diversity and the Demographic History of Modern Humans,” Proceedings of the National Academy of Sciences 94 (1997): 3100–3103; Jorde, L. B. Bamshad, M. and Rogers, A. R., “Reconstruct Human Evolution,” supra note 38; Tishkoff, S. A. and Verrelli, B. C., “Patterns of Human Genetic Diversity: Implications for Human Evolutionary History and Disease,” Annual Review of Genomics and Human Genetics 4 (2003): 293–340; Relethford, J. H., “Genetics of Modern Human Origins and Diversity,” Annual Review of Anthropology 27 (1998): 1–23.CrossRefGoogle Scholar
Templeton, A. R., “Human Races: A Genetic and Evolutionary Perspective,” American Anthropologist 100 (1999): 632650; Marks, J., 98% Chimpanzee, supra note 27; Rhode, D. L. Olson, S. and Chang, J. T., “Modelling the Recent Common Ancestry of All Living Humans,” Nature 431 (2004): 562–566, at 565. (“No large group is known to have maintained complete reproductive isolation for extended periods. The populations on either side of the Bering Strait appear to have exchanged mates throughout the period documented in the archeological record.”)CrossRefGoogle Scholar
Rhode, D. L. Olson, S. and Chang, J. T., supra note 40, at 565. Of course, people alive today have received markedly different proportions of DNA from that common ancestor.Google Scholar
Collins, F. S. et al., “A Vision for the Future,” supra note 35; The International HapMap Consortium, “The International Hap-map,” supra note 7; Foster, M. W. and Sharp, R. R., “Race, Ethnicity, and Genomics: Social Classifications as Proxies of Biological Heterogeneity,” Genome Research 12 (2002): 844850, at 845. (“Ironically, the sequencing of the human genome has instead renewed and strengthened interest in biological differences between racial and ethnic populations…”)Google Scholar
Bonham, V. L. Warshauer-Baker, E. and Collins, F. S., supra note 11, at 12.Google Scholar
Caspi, A. et al., “Role of Genotype in the Cycle of Violence in Maltreated Children,” Science 297, no. 5582 (2002): 851854; Fullerton, J. et al., “Linkage Analysis of Extremely Discordant and Concordant Sibling Pairs Identifies Quantitative-Trait Loci that Influence Variation in the Human Personality Trait Neuroticism,” American Journal of Human Genetics 72 (2003): 879–890; Collins, F. S. et al., supra note 35.CrossRefGoogle Scholar
Jorde, L. B. and Wooding, S. P., supra note 36; Kittles, R. A. and Weiss, K. M., supra note 11.Google Scholar
Jorde, L. B. and Wooding, S. P., supra note 36, at S28.CrossRefGoogle Scholar
Templeton, A. R., supra note 40.Google Scholar
Bonham, V. L. Warshauer-Baker, E. and Collins, F. S., supra note 11.Google Scholar
Jorde, L. B. and Wooding, S. P., supra note 36, at S28.CrossRefGoogle Scholar
Serre, D. and Paabo, S., “Evidence for Gradients of Human Genetic Diversity within and among Continents,” Genome Research 14 (2004): 16791685; Marks, J., supra note 27; Molnar, S., Human Variation, supra note 29; Olson, S., supra note 38.CrossRefGoogle Scholar
Tishkoff, S. A. and Williams, S. M., “Genetic Analysis of African Populations: Human Evolution and Complex Disease,” Nature Reviews Genetics 3 (2002): 611621; Jorde, L. B. and Wooding, S. P., supra note 36, at S29; Marks, J., supra note 27, at 81–85; Shriver, M. D. et al., supra note 8; Olson, S., supra note 38, at 66–69.CrossRefGoogle Scholar
Tishkoff, S. A. and Williams, S. M., supra note 51; Reich, D. E. et al., supra note 7.Google Scholar
Bonham, V. L. Warshauer-Baker, E. and Collins, F. S., supra note 11, at 12.Google Scholar
Marks, J., supra note 27.Google Scholar
Cavalli-Sforza, L. L. and Feldman, M. W., “The Application of Molecular Genetic Approaches to the Study of Human Evolution,” Nature Genetics Supplement 33 (2003): 266275.CrossRefGoogle Scholar
Loader, S. et al., “Cystic Fibrosis Carrier Population Screening in the Primary Care Setting,” American Journal of Human Genetics 59 (1996): 234247.Google Scholar
Sausville, E. A. and Carducci, M. A., “Making Bad Cells Go Good: The Promise of Epigenetic Therapy,” Journal of Clinical Oncology 23, no. 17 (2005): 38753876; Ushijima, T., “Detection and Interpretation of Altered Methylation Patterns in Cancer Cells,” Nature Reviews Cancer 5, no. 3 (2005): 223–231; Kimmins, S. and Sassone-Corsi, P., “Chromatin Remodeling and Epigenetic Features of Germ Cells,” Nature 434, no. 7033 (2005): 583–589.CrossRefGoogle Scholar
Sinden, R., “Biological Implications of the DNA Structures Associated With Disease-Causing Triplet Repeats,” American Journal of Human Genetics 64 (1999): 346353.CrossRefGoogle Scholar
For a thoughtful discussion of the complexity of quantifying genetic similarity and difference see Marks, J., supra note 27, at chapter 2.Google Scholar
Abraham, C., supra note 14; Wade, N., supra note 14.Google Scholar
This activity may be referred to as “determining one's biogeographical ancestry.” See, e.g., DNAPrint Genomics, Ancestry by DNA, DNAPrint Genomics, available at <http://www.ancestrybydna.com/> (last visited March 3, 2006). (last visited March 3, 2006).' href=https://scholar.google.com/scholar?q=This+activity+may+be+referred+to+as+“determining+one's+biogeographical+ancestry.”+See,+e.g.,+DNAPrint+Genomics,+Ancestry+by+DNA,+DNAPrint+Genomics,+available+at++(last+visited+March+3,+2006).>Google Scholar
Jorde, L. B. Carey, J. C. and White, R. L., supra note 37, at 28.Google Scholar
Lopez, I. H., supra note 32, at 27; Williams, G. H., Life on the Color Line: The True Story of a White Boy Who Discovered He Was Black (New York: Penguin Group, 1995).Google Scholar
The term “marker” refers to any position in the genome at which scientists can detect a genetic difference among people.Google Scholar
Bamshad, M. et al., supra note 11; Evett, I. W. et al., supra note 19; Jorde, L. B. and Wooding, S. P., supra note 36; Rosenberg, N. A. et al., supra note 7; DNAPrint Genomics, supra note 61.Google Scholar
Tang, M. X. et al., “The Apoe-E4 Allele and the Risk of Alzheimer Disease among African Americans, Whites and Hispanics,” JAMA 279, no. 10 (1998): 751755; Rosenberg, N. A. et al., supra note 7.CrossRefGoogle Scholar
Wade, N., “Articles Highlight Different Views on Genetic Basis of Race,” The New York Times, national edition, October 27, 2004, at A18; Burchard, E. G. et al., supra note 18; Wade, N., supra note 14.Google Scholar
Rosenberg, N. A. et al., supra note 7; Serre, D. and Paabo, S., supra note 50.Google Scholar
Gulcher, J. Helgason, A. and Stefansson, K., “Genetic Homogeneity of Icelanders,” Nature Genetics 26 (2000): 365; cf., Arnason, E. Sigurgislason, H. and Benedikz, E., “Genetic Homogeneity of Icelanders: Fact or Fiction,” Nature Genetics 25 (2000): 373–374.CrossRefGoogle Scholar
Helgason, A. et al., “An Icelandic Example of the Impact of Population Structure on Association Studies,” Nature Genetics 37 (2005): 9095, at 93; see also, Tang, H. Quertermous, T. et al., “Genetic Structure, Self-Identified Race/Ethnicity, and Confounding in Case-Control Association Studies,” American Journal of Human Genetics 76 (2004): 268–275, at 273 (reporting that self-identified Hispanic subjects in their sample could be grouped together in one cluster, but that “one prior study of Hispanics did not suggest a distinct cluster for this group, possibly because of the heterogeneous origins of that Hispanic sample. From the genetic perspective, Hispanics generally represent a differential mixture of European, Native American and African ancestry…”).CrossRefGoogle Scholar
Jorde, L. B. Carey, J. C. and White, R. L., supra note 37, at 83–101; Gerard, L. Gerard, N. and Mercier, G., “North African Genes in Iberia Studied by Y-Chromosome DNA Haplotype V,” Human Immunology 62 (2001): 885888.Google Scholar
Olson, S., “Mapping Human History,” supra note 38.Google Scholar
Harpending, H. C. et al., “Genetic Traces,” supra note 39; Jorde, L. B. Bamshad, M. and Rogers, A. R., supra note 38; Macaulay, V. et al., “The Emerging Tree of West Eurasian mtDNAs: A Synthesis of Control Region Sequences and RFLPs,” American Journal of Human Genetics 64 (1999): 232249.Google Scholar
Salas, A. Carrecedo, A. et al., “Charting the Ancestry of African Americans,” American Journal Human Genetics 77 (2005): 676680 (concluding that mtDNA variants cannot be used to trace one's African ancestry to particular tribes or to particular localities within West Africa, and stating that “Considerable caution is therefore warranted when dealing with claims in the popular media…and those made by genetic ancestry testing companies about their ability to trace the ancestry of certain American – or, for that matter, European – mtDNAs to a particular locale or population within modern-day Africa. Our analyses stand as a warning to unsuspecting members of the public who may be seduced by such promises,” at 679).CrossRefGoogle Scholar
Olson, S., supra note 38.Google Scholar
Autosomes are the chromosomes that do not determine sex, in contrast to the sex-determining chromosomes X and Y.Google Scholar
See, Ancestry by DNA webpage, at <http://www.ancestrybydna.com/welcome/productsandservices/AncestryByDNA/casestudies/family.html> (last visited March 7, 2006). Child 1 is assigned 37% European ancestry, 15% African ancestry, and 38% American Indian ancestry; Child 2 is assigned 60% European ancestry, 2% African ancestry, and 38% American Indian ancestry; Child 3's ancestral proportions fall between the those of the other two children.+(last+visited+March+7,+2006).+Child+1+is+assigned+37%+European+ancestry,+15%+African+ancestry,+and+38%+American+Indian+ancestry;+Child+2+is+assigned+60%+European+ancestry,+2%+African+ancestry,+and+38%+American+Indian+ancestry;+Child+3's+ancestral+proportions+fall+between+the+those+of+the+other+two+children.>Google Scholar
Jorde, L. B. and Wooding, S. P., supra note 36; Bamshad, M. et al., supra note 11; Serre, D. and Paabo, S., supra note 50.Google Scholar
Serre, D. and Paabo, S., supra note 50.Google Scholar
Rhode, D. L. Olson, S. and Chang, J. T., supra note 40, at 565.Google Scholar
DNAPrint Genomics, supra note 61.Google Scholar
This claim should be qualified. In some research, some of the markers used might be within a disease-associated gene, but because of the manner in which the markers are chosen and the research is conducted, the researchers would not know that one of their markers was in a “disease gene.” If commercial ancestry testing firms are using any known disease-associated markers in their analyses, they have not disclosed this information.Google Scholar
Bobadilla, J. L. et al., “Cystic Fibrosis: A Worldwide Analysis of CFTR Mutations – Correlation with Incidence Data and Application to Screening,” Human Mutation 19, no. 6 (2002): 575606.CrossRefGoogle Scholar
This allele probably arose two separate times in human history, once when a mutation occurred in a Northern Italian person and another time when the same mutation occurred in a Zuni ancestor. Bobadilla, J. L. et al., supra note 83.Google Scholar
See Abraham, C., supra note 14.Google Scholar
Parra, F. C. Amado, R. C. et al., “Color and Genomic Ancestry in Brazilians,” Proceedings of the National Academy of Sciences 100, no. 1 (2003): 177182.CrossRefGoogle Scholar
Parra, F. C. et al., supra note 86. Another way of saying this is that, due to the randomness of inheritance, one could have inherited the markers used to trace ancestry and the alleles that encode visible traits from different ancestors.Google Scholar
Lamason, R. L. Mohideen, M. A. et al., “SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans,” Science 310 (2005): 17821786, at 1786, figure 6.CrossRefGoogle Scholar
DNAPrint Genomics, supra note 61.Google Scholar
Hispanic/Latina identity has been quite contested throughout US history and remains so today. Although the U.S. government considers Hispanic an ethnicity, and therefore views it as possible for a person to be Hispanic and a member of any race, many Hispanics designate their race as “other” on the census, perhaps because they do not experience themselves as belonging to one of the “big four” races, see Lopez, I. H., “Race on the 2010 Census: Hispanics and the shrinking White Majority,” Daedalus 134 (2005): 4252, (noting that in 1990, 97.5% of the people choosing “other race” on the census form also checked Hispanic ethnicity, p. 45). In much of the biomedical and genetics literature, the term Hispanic is treated as a race insofar as being Hispanic is viewed as mutually exclusive with being white, American Indian, or African American. Here, I use Hispanic as an ethnicity, and choose the relatively common representation of a white Hispanic person and a non-Hispanic Native American person. My use of this example should not be seen as an endorsement of any particular conception or usage of the term Hispanic.CrossRefGoogle Scholar
Barsh, G. S., supra note 8; Strum, R. A. Box, N. F. and Ramsay, M., “Human Pigmentation Genetics: The Difference is Only Skin Deep,” BioEssays 20 (1998): 712721; Roh, K. Y. et al., supra note 8.Google Scholar
Strum, R. A. Box, N. F. and Ramsay, M., supra note 91, at 720 (1998). Normal variation in human skin color involves mixtures of at least two pigment types-red-yellow pheomelanin and black-brown eumelanin (Barsh, G. S., supra note 8, at 19). People with carrot-red hair, fair skin and freckles make large quantities of pheomelanin and small quantities of eumelanin relative to people with other phenotypes. In populations where red hair and fair skin are common, such as people of English or Irish ancestry, this “carrot-top” phenotype can be caused by a loss-of-function mutation in the melanocortin 1 receptor gene (MC1R). Certain combinations of rare MC1R variants may also cause blonde hair. However, red and blonde hair phenotypes also can be caused by genes other than MC1R. Furthermore, variation in the MC1R gene plays little role in average skin color variation between racial groups. Id. Diet, sun exposure, gender, age and other as yet unknown determinants also play some role, Roh, K. Y. et al., supra note 8.Google Scholar
Lamason, R. L. et al., “SLC24A5, a Putative Cation Exchanger, Affects Pigmentation in Zebrafish and Humans,” Science 310 (2005): 17821786.CrossRefGoogle Scholar
Lamason, R. L. et al., supra note 93.Google Scholar
Lamason, R. L. et al., supra note 93, at 1786 (see figure 6, at least three subjects are indicated as being of 100% African ancestry and homozygous for the recent SLC24A5 allele).Google Scholar
But, see, Abraham, C., supra note 14, reporting that DNAPrint Genomics is working on a technology that could translate a genotype into a “crude sketch of a suspect.”Google Scholar
Cho, M. K. and Sankar, P., supra note 19.Google Scholar
Scheck, B. Neufeld, P. and Dwyer, J., supra note 3, at chapter 3.Google Scholar
“The Future of Forensic DNA Testing,” supra note 4; Kaye, D. and Smith, M. E., “DNA Identification Databases: Legality, Legitimacy, and the Case for Population-Wide Coverage,” Wisconsin Law Review (2003): 413459; Collins, F. S. et al., “A Vision for the Future,” supra note 35, at 289, noting that when the Human Genome Project began, the cost of obtaining high-quality DNA sequence information was approximately $10 per nucleotide; but by 2003, when a comprehensive reference human genome sequence had been completed, the cost was less than ten cents per nucleotide and continuing to drop.Google Scholar
See, e.g., Harris, D. A., “The Statistics and the Law: Why ‘Driving While Black’ Matters,” Minnesota Law Review, 84, no. 265 (1999): 265326; Taylor, S., “Racial Profiling: The Liberals are Right,” National Journal, April 24, 1999, reproduced at <http://nationaljournal.com.ezproxy.library.wisc.edu/pubs/nj/> (last visited March 08, 2006); Ossorio, P. N. and Duster, T., “Race and Genetics: Controversies,” supra note 18, at 122–126. Plenty of scholars would contest the claim that police treatment of minorities is biased. For an interesting challenge to claims of unjust racial profiling in stops and searches, see Perisco, N. and Castleman, D., “Detecting Bias: Using Statistical Evidence to Establish Intentional Discrimination in Racial Profiling Cases,” The University of Chicago Legal Forum (2005): 1–19; and Knowles, J. Persico, N. and Todd, P., “Racial Bias in Motor Vehicle Searches: Theory and Evidence,” Journal of Political Economy 109, no. 1 (2001): 203–229Google Scholar
Kaye, D. and Smith, M.E., supra note 99, at 10; Ossorio, P. and Duster, T., supra note 18, at 123–124.Google Scholar
This argument assumes that racially pernicious stereotypes are not built into the forensic genetic tests.Google Scholar
For instance, if it could be shown that trait genetic testing improved the apprehension rate for perpetrators of crimes in minority communities, then minority communities with disproportionately high crime rates might benefit. This benefit would only occur, however, if police divisions or departments that served minority communities possessed the resources to obtain proper training in sample collection and preparation, and to pay for genetic tests.Google Scholar
Reviewed in, Eberhardt, J. L. et al., “See Black: Race, Crime, and Visual Processing,” Journal of Personality and Social Psychology 87, no. 6 (2004): 876893; Heumann, M. and Cassak, L., “Profiles in Justice? Police Discretion, Symbolic Assailants, and Stereotyping,” Rutgers Law Review 53 (2001): 911–978, at 914–918; Kang, J., “The Trojan Horse of Race,” Harvard Law Review 118 (2005): 1489–1593; Lee, C., “But I Thought He Had a Gun: Race and Police Use of Deadly Force,” Hastings Race and Poverty Law Journal 2 (2004): 1–51.CrossRefGoogle Scholar
Eberhardt, J. L. et al., supra note 104, at 876.Google Scholar
Leaper, C. and Bigler, R. S., “Gendered Language and Sexist Thought,” Monographs of the Society for Research in Child Development 69, no. 1 (2004): 128142; Spears, B. C. and Bigler, R. S., “Children's Perceptions of Gender Discrimination,” Developmental Psychology 40, no. 5 (2004): 714–726; Spears, B. C. and Bigler, R. S., “Children's Perceptions of Discrimination: A Developmental Model,” Child Development 76, no. 3 (2005): 533–553; Bigler, R. S., “Good Morning Boys and Girls: When a Simple Greeting Engenders Stereotypes,” Teaching Tolerance Fall (2005): 22–23, at 22 (an article written for a lay audience, describing the ways in which people who work with children, such as elementary school teachers, unwittingly promote stereotypes by using gender when assigning tasks such as lining up for recess or writing at the board. “A teacher's use of gender labels also can cause children to perform poorly on tasks at which they would normally excel…Studies show that thinking about gender causes girls to perform significantly worse on a challenging math test…”)CrossRefGoogle Scholar
Biernat, M. and Ma, J. E., “Stereotypes and the Confirmability of Trait Concepts,” Personality and Social Psychology Bulletin 31, no. 4 (2005): 483495; Blair, I. V. Judd, C. M. and Fallman, J. L., “The Automaticity of Race and Afrocentric Facial Features in Social Judgments,” Journal of Personality and Social Psychology 87, no. 6 (2004): 763–778; Dovidio, J. F. and Gaertner, S. L., “On the Nature of Contemporary Prejudice: The Causes, Consequences, and Challenges of Aversive Racism,” in Eberhardt, J. L. and Fiske, S. T., eds., Confronting Racism: The Problem and the Response (Thousand Oaks, CA: Sage, 1998): 3–32; Dovidio, J. F. and Gaertner, S. L., “Aversive Racism and Selection Decisions,” Psychological Science 11 (1999): 315–319; Hugenberg, K. and Bodenhausen, G. V., “Ambiguity in Social Categorization: The Role of Prejudice and Facial affect in Race Categorization,” Psychological Science 15, no. 5 (2004): 342–345; Norton, M. I. Vandello, J. A. and Darley, J. M., “Casuistry and Bias,” Journal of Personality and Social Psychology 87, no. 6 (2004): 817–831; Sherman, J. W. et al., “Prejudice and Stereotype Maintenance Processes: Attention, Attribution, and Individuation,” Journal of Personality and Social Psychology 89, no. 4 (2005): 607–622.Google Scholar
See, e.g., Eberhardt, J. L. et al., “Seeing Black,” supra note 104; Levin, D. T., “Race as a Visual Feature: Using Visual Search and Perceptual Discrimination Tasks to Understand Face Categories and the Cross-Race Recognition Deficit,” Journal of Experimental Psychology: General 129, no. 4 (2000): 559574; Sangrigoli, S. et al., “Reversibility of the Other-Race Effect in Face Recognition During Childhood,” Psychological Science 16, no. 6 (2005): 440–444.Google Scholar
Condit, C. et al., “Exploration of the Impact of Messages About Genes and Race on Lay Attitudes,” Clinical Genetics 66 (2004): 402408.CrossRefGoogle Scholar
See, e.g., News and Editorial Staff of Science, “Discoveries of the Year: The Runners Up: Decoding Mental Illness,” Science 302 (2003): 2039; Jacob, C. P. et al., “Cluster B Personality Disorders are Associated with Allelic Variation of Monamine Oxidase A Activity,” Neuropsychopharmacology 30 (2005): 1711–1718; Yu, Y. et al., “Association Study of a Functional MAOA-UVNTR Gene Polymorphism and Personality Traits in Chinese Young Females,” Neuropsychobiology 52 (2005): 118–121; Sawa, A. and Snyder, S. H., “Schizophrenia: Diverse Approaches to a Complex Disease,” Science 296 (2002): 692–695.Google Scholar
See, e.g., Hariri, A. R. et al., “Serotonin Transporter Genetic Variation and the Response of the Human Amygdala,” Science 297 (2002): 400403; Stallings, M. C. et al., “A Genome-Wide Search for Quantitative Trait Loci that Influence Antisocial Drug Dependence in Adolescence,” Archives of General Psychiatry 62 (2005): 1042–1051; Eley, T. C. et al., “Association Analysis of MAOA and COMT with Neuroticism Assessed by Peers,” American Journal of Medical Genetics Part B (Neuropsychiatric Genetics) 120B (2003): 90–96.CrossRefGoogle Scholar
Smalley, S. L. et al., “Genetic Linkage of Attention-Deficit/Hyperactivity Disorder on Chromosome 16 p13, in a Region Implicated in Autism,” American Journal of Human Genetics 71, no. 4 (2002): 959963; Kandel, E. R., “The Molecular Biology of Memory Storage: A Dialogue between Genes and Synapses,” Science 294 (2001): 1030–1038; see, generally, Rothstein, M. A., “Applications of Behavioural Genetics: Outpacing the Science?” Nature Reviews Genetics 6 (2005): 793–798.CrossRefGoogle Scholar
Caspi, A. et al., supra note 44; Rothstein, M. A., supra note 113, at 794; Jacob, C. P. et al., supra note 111.Google Scholar
Rothstein, M. A., “Behavioural Genetics Applications,” supra note 113, at 794; Hogg, R. C. and Bertrand, D., “What Genes Tell us about Nicotine Addiction,” Science 306 (2004): 983984; Potenza, M. N. et al., “Shared Genetic Contributions to Pathological Gambling and Major Depression in Men,” Archives of General Psychiatry 62 (2005): 1015–1021.Google Scholar
Rothstein, M. A. and Carnahan, S., “Expanding the Scope of Law Enforcement DNA Databanks”, Brooklyn Law Review 67 (2001): 127170.Google Scholar
DNA in “Minor” Crimes Yields Major Benefits in Public Safety (Washington, DC: U.S. Department of Justice, Office of Justice Programs, National Institute of Justice, 2004): 13.Google Scholar
Health Insurance Portability and Accountability Act of 1996, Pub. L. No. 104-191, 110 Stat. 1936 (1996)(codified in scattered sections of 26 U.S.C., 28 U.S.C. and 42 U.S.C.)Google Scholar
Alpert, S., “Privacy and Analysis of Stored Tissues,” in NBAC, ed., Research Involving Human Biological Materials: Ethical Issues and Policy Guidance, 2 vol. 2 (Washington, DC, 2000): A1A33; Buchanan, A., “An Ethical Framework for Biological Samples Policy,” in NBAC, ed., Research Involving Human Biological Materials: Ethical Issues and Policy Guidance, vol. 2 (Washington, DC, 2000): B1–B31; Rothstein, M. A., Genetic Secrets: Protecting Privacy and Confidentiality in the Genetic Era (New Haven: Yale University Press, 1997); Genetic Technologies Project: Genetic Laws and Legislative Activity, National Conference of State Legislatures website, available at <http://www.ncsl.org/programs/health/genetics/charts.htm> (last visited March 3, 2006).Google Scholar
Jorde, L. B. Carey, J. C. and White, R. L., supra note 37, at 72.Google Scholar