Twenty-two cases of carcinoma of the head and neck (predominantly squamous), in a veriety of sites, were treated with an oncolytic regime of Adriamycin and Bleomycin. Adjuvant hyperthermia was given to all cases; differing techniques of drug administration were used, depending on whether a case had received previous irradiation. Twenty-one cases showed response to treatment. Post-irradiation cases fared less well than those in which radiotherapy was synchronised with treatment.

This paper describes the management of patients undergoing synchronous combined chemotherapy and radiotherapy at King's College Hospital. It is based on the experience of treating 96 patients with carcinoma of the head and neck between 1974–1978.

A detailed account is given of the method of conducting the treatment. The routine assessment, investigations and follow-up are described, together with the complications due to individual drugs and general effects of combined therapy and their management. Great stress is laid on the need for active, intensive nursing care of these patients.

An uncommon bilateral transitional-type inverted papilloma of the nose and paranasal sinuses is presented, and the salient features of the lesion are discussed. The patient is well and without any signs of recurrence in either side of the nose more than two years after the first diagnosis and complete surgical excision of both tumours.

Commonly unilateral, this tumour may occasionally be bilateral. In the present communication an uncommon case of bilateral inverted transitional-type papilloma, with a long history of allergy, is described with some comments on its pathogenesis.