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Variable expression of molecular markers in juvenile nasopharyngeal angiofibroma

Published online by Cambridge University Press:  07 July 2017

A Mishra ,
A Pandey  and
S C Mishra
A Mishra*
Affiliation:
Department of Otorhinolaryngology, Nepalgunj Medical College, Nepal
A Pandey
Affiliation:
Department of Otorhinolaryngology, Nepalgunj Medical College, Nepal
S C Mishra
Affiliation:
Department of Obstetrics and Gynaecology, King George Medical University, Lucknow, India
*
Address for correspondence: Dr A Mishra, A-1/19, Sector H Aliganj, Lucknow, Uttar Pradesh, India E-mail: [email protected]
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Abstract

Background:

Molecular categorisation may explain the wide variation in the clinical characteristics of juvenile nasopharyngeal angiofibroma.

Methods:

Variations in molecular markers in juvenile nasopharyngeal angiofibroma in an Indian population were investigated and compared with global reports.

Results:

Variable molecular marker expression was demonstrated at the regional and global levels. A wide variation in molecular characteristics is evident. Molecular data have been reported for only 11 countries, indicating a clear geographical bias. Only 58 markers have been studied, and most are yet to be validated.

Conclusion:

Research into the molecular epidemiology of juvenile nasopharyngeal angiofibroma is still in its infancy. Although the molecular variation is not well understood, data obtained so far have prompted important research questions. Hence, multicentre collaborative molecular studies are needed to establish the aetiopathogenesis and establish molecular surrogates for clinical characteristics.

Keywords

AngiofibromaNasopharynxVascular Endothelial Growth Factor AFibroblast Growth FactorsPlatelet-Derived Growth Factorbeta CateninReceptorsAndrogen
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 9 , September 2017 , pp. 752 - 759
Copyright
Copyright © JLO (1984) Limited 2017 

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Footnotes

This review is based PhD work of Dr Anupam Mishra.

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