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Value of lymph node biopsy in the diagnosis of acquired toxoplasmosis

Published online by Cambridge University Press:  29 June 2007

Nukhet Tuzuner ,
Gülen Doǧusoy ,
Cuyan Demirkesen ,
Ferda Ozkana  and
Kemal Altas
Nukhet Tuzuner
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Gülen Doǧusoy*
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Cuyan Demirkesen
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Ferda Ozkana
Affiliation:
Department of Pathology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
Kemal Altas
Affiliation:
Department of Microbiology, University of Istanbul, Cerrahpaşa Medical School, Istanbul, Turkey
*
Address for correspondence: Gülen Doǧusoy, Cerrahpaşa Tip Fakültesi, Patoloji ABD, Aksaray, Istanbul, Turkey. Fax: 0212 632 00 50
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Abstract

Toxoplasmic lymphadenitis generally involves a solitary lymph node in the head and neck regions, without systemic symptoms. In order to determine the frequency of toxoplasmic lymphadenitis, we reviewed the histological sections of 731 consecutive patients with reactive lymph node hyperplasia. Amongst 731 patients, 112 had histological features supporting a diagnosis of toxoplasmic lymphadenitis (15.3 per cent). In 80 of these patients (71 per cent), either Indirect Haemaglutination test (IHA), in 37 cases, or the Enzyme-Linked Immunosorbent Assay (ELISA) for detecting toxoplasmic IgG or IgM antibodies, in 43 cases, were performed. In 76 out of 80 patients (95 per cent), histological features correlated well with serological studies. The IHA test was positive in 30 patients with a titre of 1/64 or higher. The IgG-ELISA test was positive in 11 whereas the IgM-ELISA test was positive in 28 patients. These results provide further evidence of the distinctive nature of the histological changes in toxoplasmic lymphadenitis, which should enable the clinician to make a confident diagnosis of acute acquired toxoplasmosis.

Keywords

Toxoplasmosis, acquiredLymph nodesBiopsy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 4 , April 1996 , pp. 348 - 352
Copyright
Copyright © JLO (1984) Limited 1996

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