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Unusual location for Castleman's disease

Published online by Cambridge University Press:  02 December 2008

H G Rao ,
I Street  and
R Capper
H G Rao*
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
I Street
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
R Capper
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
*
Corresponding author: Dr Harish G Rao, Flat 90, 3 Whitehall Quay, Leeds LS1 4BW, UK. E-mail: [email protected]
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Abstract

Objective:

We present the first reported case of persistent, posterior triangle lymphadenopathy in a child, caused by Castleman's disease.

Case report:

A seven-year-old boy presented with a painless swelling in the posterior triangle of his left neck, with no compression of the surrounding structures. A histological diagnosis of Castleman's disease was made. Eventual treatment was by complete excision. At six-month follow up, there were no signs of recurrence.

Conclusion:

The causes of persistent cervical lymphadenopathy in children are many. Most are not significant, but some are life-threatening. Castleman's disease should be considered as a possible diagnosis in persistent childhood lymphadenopathy.

Keywords

LymphadenopathyNeckChildCastleman's Disease
Type
Online Only Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 1 , January 2009 , e3
Copyright
Copyright © JLO (1984) Limited 2008

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References

1 Castleman, B, Towne, VW. Case records of Massachusset's General Hospital. N Engl J Med 1954;250:26–30Google Scholar
2 Minerva, T, Franza, R. Castleman's disease with diffuse cervical localization: case report. Acta Otorhinolaryngol Belg 2004;24:234–8Google ScholarPubMed
3 Palma, D, Dar, A, Millington, SJ, Smits, CL, Rizkalla, K, Inculet, R. Castleman's disease in children: report of 2 cases and clinicopathologic review. J Pediatr Hematol Oncol 2004;26:264–6CrossRefGoogle ScholarPubMed
4 Parez, N, Bader-Meunier, B, Roy, CC, Dommergues, JP. Pediatric Castleman disease: report of seven cases and review of the literature. Eur J Pediatric 1999;158:631–7Google Scholar
5 Smir, BN, Greiner, TC, Weisenburger, DD. Multicentric angiofollicular lymph node hyperplasia in children: a clinicopathologic study of eight patients. Mod Pathol 1996;1135–42Google Scholar
6 Gaba, AR, Stein, RS, Sweet, DL, Variakojis, D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol 1978;69:86–90Google Scholar
7 Weisenburger, DD, Nathwani, BN, Winberg, CD, Rappaport, H. Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol 1985;16:162–72Google Scholar
8 Ishiyama, T, Koike, M, Nakamura, S, Kakimoto, T, Akimoto, Y, Tsuruoka, N. Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease. Ann Hematol 1996;73:179–82CrossRefGoogle ScholarPubMed
9 Ohyashiki, JH, Ohyashiki, K, Kawakubo, K, Serixawa, H, Abe, K, Mikata, A et al. Molecular genetic, cytogenetic, and immuno-phenotypic analyses in Castleman's disease of the plasma cell type. Am J Clin Pathol 1994;101:290–5CrossRefGoogle Scholar
10 emedicine. http://www.emedicine.com/derm/topic771.htm [15/09/2007]Google Scholar
11 Bowne, BW, Lewis, JJ, Filippa, DA, Niesvizky, R, Brooks, AD, Burt, ME et al. The management of unicentric and multicentric Castleman's disease. Cancer 1999;85:706–173.0.CO;2-7>CrossRefGoogle ScholarPubMed