Hostname: page-component-586b7cd67f-t8hqh Total loading time: 0 Render date: 2024-11-22T18:29:16.170Z Has data issue: false hasContentIssue false
  • English
  • Français

Unusual location for Castleman's disease

Published online by Cambridge University Press:  02 December 2008

H G Rao ,
I Street  and
R Capper
H G Rao*
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
I Street
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
R Capper
Affiliation:
Department of Otolaryngology, Doncaster Royal Infirmary, UK
*
Corresponding author: Dr Harish G Rao, Flat 90, 3 Whitehall Quay, Leeds LS1 4BW, UK. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We present the first reported case of persistent, posterior triangle lymphadenopathy in a child, caused by Castleman's disease.

Case report:

A seven-year-old boy presented with a painless swelling in the posterior triangle of his left neck, with no compression of the surrounding structures. A histological diagnosis of Castleman's disease was made. Eventual treatment was by complete excision. At six-month follow up, there were no signs of recurrence.

Conclusion:

The causes of persistent cervical lymphadenopathy in children are many. Most are not significant, but some are life-threatening. Castleman's disease should be considered as a possible diagnosis in persistent childhood lymphadenopathy.

Keywords

LymphadenopathyNeckChildCastleman's Disease
Type
Online Only Clinical Records
Information
The Journal of Laryngology & Otology , Volume 123 , Issue 1 , January 2009 , e3
Copyright
Copyright © JLO (1984) Limited 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1 Castleman, B, Towne, VW. Case records of Massachusset's General Hospital. N Engl J Med 1954;250:26–30Google Scholar
2 Minerva, T, Franza, R. Castleman's disease with diffuse cervical localization: case report. Acta Otorhinolaryngol Belg 2004;24:234–8Google ScholarPubMed
3 Palma, D, Dar, A, Millington, SJ, Smits, CL, Rizkalla, K, Inculet, R. Castleman's disease in children: report of 2 cases and clinicopathologic review. J Pediatr Hematol Oncol 2004;26:264–6CrossRefGoogle ScholarPubMed
4 Parez, N, Bader-Meunier, B, Roy, CC, Dommergues, JP. Pediatric Castleman disease: report of seven cases and review of the literature. Eur J Pediatric 1999;158:631–7Google Scholar
5 Smir, BN, Greiner, TC, Weisenburger, DD. Multicentric angiofollicular lymph node hyperplasia in children: a clinicopathologic study of eight patients. Mod Pathol 1996;1135–42Google Scholar
6 Gaba, AR, Stein, RS, Sweet, DL, Variakojis, D. Multicentric giant lymph node hyperplasia. Am J Clin Pathol 1978;69:86–90Google Scholar
7 Weisenburger, DD, Nathwani, BN, Winberg, CD, Rappaport, H. Multicentric angiofollicular lymph node hyperplasia: a clinicopathologic study of 16 cases. Hum Pathol 1985;16:162–72Google Scholar
8 Ishiyama, T, Koike, M, Nakamura, S, Kakimoto, T, Akimoto, Y, Tsuruoka, N. Interleukin-6 receptor expression in the peripheral B cells of patients with multicentric Castleman's disease. Ann Hematol 1996;73:179–82CrossRefGoogle ScholarPubMed
9 Ohyashiki, JH, Ohyashiki, K, Kawakubo, K, Serixawa, H, Abe, K, Mikata, A et al. Molecular genetic, cytogenetic, and immuno-phenotypic analyses in Castleman's disease of the plasma cell type. Am J Clin Pathol 1994;101:290–5CrossRefGoogle Scholar
10 emedicine. http://www.emedicine.com/derm/topic771.htm [15/09/2007]Google Scholar
11 Bowne, BW, Lewis, JJ, Filippa, DA, Niesvizky, R, Brooks, AD, Burt, ME et al. The management of unicentric and multicentric Castleman's disease. Cancer 1999;85:706–173.0.CO;2-7>CrossRefGoogle ScholarPubMed