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Tularaemia of middle ear with suppurative lymphadenopathy and retropharyngeal abscess

Published online by Cambridge University Press:  02 March 2009

R Gürkov*
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, University of Munich, Germany
U Kisser
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, University of Munich, Germany
W Splettstösser
Affiliation:
Institute of Microbiology, Federal Armed Forces Medical Academy Munich, Germany
M Hogardt
Affiliation:
Max von Pettenkofer Institute for Hygiene and Medical Microbiology, University of Munich, Germany
E Krause
Affiliation:
Department of Otorhinolaryngology Head and Neck Surgery, University of Munich, Germany
*
Address for correspondence: Dr Robert Gürkov, Department of Otorhinolaryngoloy Head and Neck Surgery, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Fax: +49 89 7095 6869 E-mail: [email protected]

Abstract

Objective:

We report an extremely rare case of otitis media due to Francisella tularensis, complicated by multiple suppurative cervical lesions and a lasting conductive hearing loss.

Case report:

A young woman presented with otitis media, several neck swellings and a retropharyngeal swelling. Polymerase chain reaction testing of aspirated fluid and serology confirmed the diagnosis of tularaemia. Specific antibiotic therapy initiated six weeks after the onset of initial symptoms did not resolve the disease, and open surgical drainage was necessary.

Conclusions:

Otitis media unresponsive to conventional therapy and accompanied by unusually pronounced lymphadenopathy should prompt the clinician to consider tularaemia as a differential diagnosis, in order to initiate timely, specific therapy.

Type
Clinical Records
Copyright
Copyright © JLO (1984) Limited 2009

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References

1Ellis, J, Oyston, PC, Green, M, Titball, RW. Tularemia. Clin Microbiol Rev 2002;15:631–46CrossRefGoogle ScholarPubMed
2Schmid, GP, Kornblatt, AN, Connors, CA, Patton, C, Carney, J, Hobbs, J et al. Clinically mild tularemia associated with tick-borne Francisella tularensis. J Infect Dis 1983;148:63–7CrossRefGoogle ScholarPubMed
3Robert-Koch-Institut. Tularemia – Epidemiology in Germany [in German]. Epidemiol Bull 2007/Nr.7Google Scholar
4Capellan, J, Fong, IW. Tularemia from a cat bite: case report and review of feline-associated tularaemia. Clin Infect Dis 1993;16:472–4CrossRefGoogle Scholar
5Gill, V, Cunha, BA. Tularemia pneumonia. Semin Respir Infect 1997;12:61–7Google ScholarPubMed
6Peter, R, Banyai, T. Erythema nodosum revealing oculoglandular tularemia. Dermatology 2001;202:7980CrossRefGoogle ScholarPubMed
7Luotonen, L, Tapiainen, T, Kallioinen, M, Luotonen, J. Tularemia of the middle ear. Pediatr Infect Dis J 2002;21:264–5CrossRefGoogle ScholarPubMed
8Splettstoesser, WD, Matz-Rensing, K, Seibold, E, Tomaso, H, Al Dahouk, S, Grunow, R et al. Re-emergence of Francisella tularensis in Germany: fatal tularaemia in a colony of semi-free-living marmosets (Callithrix jacchus). Epidemiol Infect 2007;135:1256–65CrossRefGoogle Scholar
9Fujita, O, Tatsumi, M, Tanabayashi, K, Yamada, A. Development of a real-time PCR assay for detection and quantification of Francisella tularensis. Jpn J Infect Dis 2006;59:4651CrossRefGoogle ScholarPubMed
10Bystrom, M, Bocher, S, Magnusson, A, Prag, J, Johansson, A. Tularaemia in Denmark: identification of a Francisella tularensis subsp. holarctica strain by real-time PCR and high-resolution typing by multiple-locus variable-number tandem repeat analysis. J Clin Microbiol 2005;43:5355–8CrossRefGoogle ScholarPubMed
11Broekhuijsen, M, Larsson, P, Johansson, A, Bystrom, M, Eriksson, U, Larsson, E et al. Genome-wide DNA microarray analysis of Francisella tularensis strains demonstrates extensive genetic conservation within the species but identifies regions that are unique to the highly virulent F. tularensis subsp. tularensis. J Clin Microbiol 2003;41:2924–31CrossRefGoogle Scholar
12Schmitt, P, Splettstoesser, W, Porsch-Ozcurumez, M, Finke, EJ, Grunow, R. A novel screening ELISA and a confirmatory Western blot useful for diagnosis and epidemiological studies of tularemia. Epidemiol Infect 2005;133:759–66CrossRefGoogle Scholar
13Johansson, A, Berglund, L, Eriksson, U, Goransson, I, Wollin, R, Forsman, M et al. Comparative analysis of PCR versus culture for diagnosis of ulceroglandular tularemia. J Clin Microbiol 2000;38:22–6CrossRefGoogle ScholarPubMed
14Staples, JE, Kubota, KA, Chalcraft, LG, Mead, PS, Petersen, JM. Epidemiologic and molecular analysis of human tularemia, United States, 1964–2004. Emerg Infect Dis 2006;12:1113–18CrossRefGoogle ScholarPubMed
15Wills, PI, Gedosh, EA, Smith, F, Nichols, DR. Head and neck manifestations of tularemia. Laryngoscope 1982;92:770–3CrossRefGoogle ScholarPubMed
16Everett, ED. Clinical manifestations, diagnosis, and treatment of tularaemia. 2007. Available via uptodate.com, accessed June 24th 2008Google Scholar
17Enderlin, G, Morales, L, Jacobs, RF, Cross, JT. Streptomycin and alternative agents for the treatment of tularemia: review of the literature. Clin Infect Dis 1994;19:42CrossRefGoogle ScholarPubMed
18Tärnvik, A, Chu, MC. New approaches to diagnosis and therapy of tularemia. Ann N Y Acad Sci 2007;1105:378404CrossRefGoogle ScholarPubMed
19Johansson, A, Berglund, L, Gothefors, L, Sjöstedt, A, Tärnvik, A. Ciprofloxacin for treatment of tularemia in children. Pediatr Infect Dis J 2000;19:449–53CrossRefGoogle ScholarPubMed
20Limaye, AP, Hooper, CJ. Treatment of tularemia with fluoroquinolones: two cases and review. Clin Inf Dis 1999;29:922–4CrossRefGoogle Scholar
21Tarnvik, A, Berglund, L. Tularemia. Eur Respir J 2003;21:361–73CrossRefGoogle Scholar
22Celebi, G, Baruönü, F, Ayoğlu, F, Cinar, F, Karadenizli, A, Uğur, MB et al. Tularemia, a reemerging disease in northwest Turkey: epidemiological investigation and evaluation of treatment responses. Jpn J Infect Dis 2006;59:229–34CrossRefGoogle ScholarPubMed