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True carcinosarcoma of the larynx

Published online by Cambridge University Press:  29 June 2007

J. Klijanienko ,
P. Vielh ,
P. Duvillard  and
B. Luboinski
J. Klijanienko
Affiliation:
Histopathology A and B, 94805 Villejuif, France.
P. Vielh*
Affiliation:
Surgery Institut Gustave-Roussy, 94805 Villejuif, France.
P. Duvillard
Affiliation:
Histopathology A and B, 94805 Villejuif, France.
B. Luboinski
Affiliation:
Clinical Cytopathology, Institute Curie 75231 Paris, Cedex 05, France.
*
Docteur Philippe Vielh, Cytopathology Unit, Institute Curie, 26 rue d'Ulm, 75231 Paris Cedex 05, France.
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Abstract

A case of carcinosarcoma of the larynx and pyriform sinus with sarcomatous and epithelial malignant components is described in a 68-year-old male. The primary site was composed of spindle-shaped malignant mesenchymal cells with osteosarcomatous and chondrosarcomatous differentiation intermingled with areas of well differentiated squamous cell carcinoma, tubular and papillary adenocarcinoma, and trabecular neuroendocrine carcinoma. The metastatic lymph node showed squamous cell carcinoma and chondrosarcoma. Immunohistochemical studies showed that keratin was present in epithelial cells and negative in sarcoma, whereas vimentin and S-100 protein were present in sarcoma, but negative in carcinoma. Neuron-specific enolase was present in the neuroendocrine part of the tumour.

Keywords

Laryngeal neoplasmsCarcinosarcoma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 1 , January 1992 , pp. 58 - 60
Copyright
Copyright © JLO (1984) Limited 1992

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