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Topical antiseptic mouthwash in oncological surgery of the oral cavity and oropharynx

Published online by Cambridge University Press:  29 June 2007

Miriam I. Redleaf*
Affiliation:
Division of Otolaryngology–Head and Neck Surgery, University of Chicago Medical Centre, 5841 S. Maryland Avenue, MC 1035, Chicago, IL 60637
Carol A. Bauer
Affiliation:
Department of Otolaryngology–Head and Neck Surgery, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA.
*
Dr Miriam I. Redleaf, M.D., Division of Otolaryngology–Head and Neck Surgery, University of Chicago Medical Centre, 5841 S. Maryland Avenue, MC 1035, Chicago, Illinois 60637, USA.

Abstract

A multivariant analysis of the value of the use of a pre-operative topical antiseptic mouthwash to reduce the incidence of post-operative wound complications in 106 consecutive patients undergoing head and neck surgery involving the oral cavity or oropharynx was carried out at the University of Iowa, Department of Otolaryngology-Head and Neck Surgery. An oral presentation employing povidone–iodine solution was used for 43 patients. The remaining 63 patients studied received no oral presentation. Unfavourable wound outcome was not associated with age, sex, presence and condition of teeth, or serious pre-existing medical illnesses. A significant correlation was found between post-operative wound breakdown and type of closure, stage of disease, and previous operation or radiotherapy. The use of an oral preparation correlated significantly with favourable wound outcome independent of all other variables (p<0.01).

Our data support the use of a topical antiseptic mouthwash to reduce the incidence of post-operative wound complications in surgery of the oral cavity and oropharynx.

Type
Main Articles
Copyright
Copyright © JLO (1984) Limited 1994

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Footnotes

This manuscript was presented to the American Society for Head and Neck Surgery, Spring Meeting (April 21,1993) in Los Angeles, CA, USA.

References

Barton, R. P. E., Moir, A. A. (1983) Use of local gentamicin preparation (‘garamycin’ chains) as prophylaxis against infection in major head or neck surgery. Pharmatherapeulica 3: 327–303.Google ScholarPubMed
Becker, G. D. (1986) Identification and management of the patient at high risk for wound infection. Head and Neck 8: 205210.CrossRefGoogle ScholarPubMed
Becker, G. D., Parell, G. J. (1979) Cefazolin prophylaxis in head and neck cancer surgery. Annals of Otology, Rhinology and Laryngology 88: 183186.CrossRefGoogle ScholarPubMed
Breloff, J. P., Caffesse, R. G. (1983) Effect of achromycin ointment on healing following periodontal surgery. Journal of Periodonlology 54: 368372.CrossRefGoogle ScholarPubMed
Brown, B. M., Johnson, J. T., Wagner, R. L. (1987) Etiologic factors in head and neck wound infections. Laryngoscope 97: 587590.CrossRefGoogle ScholarPubMed
Condon, R. E., Bartlett, J. G., Nichols, R. L., Schulte, W. J., Gorbach, S. L., Ochi, S. (1979) Pre-operative prophylaxic cephalothin fails to control septic complications of colorectal operalions. American Journal of Surgery 137: 6874.CrossRefGoogle Scholar
Condon, R. E., Bartlett, J. G., Greenlee, H., Schulte, W.J., Ochi, S., Abbe, R., Caruana, J. A., Gordon, H. E., Horsley, J. S., Irvin, G. III, Johnson, W., Jordan, P. Jr, Keitzer, W. E, Lempke, R., Read, R. C., Schumer, W., Schwartz, M., Storm, F. K., Vetto, R. M. (1983) Efficacy of oral and systemic antibiotic prophylaxis in colorectal operations. Archives of Surgery 18: 496502.CrossRefGoogle Scholar
Davidson, A. I. G., Clark, C.Smith, G. (1971) Post-operative wound infection. British Journal of Surgery 58: 333337.CrossRefGoogle Scholar
Dor, P., Klastersky, J. (1973) Prophylactic antibiotics in oral, pharyngeal and laryngeal surgery for cancer. Laryngoscope 83: 19921998.CrossRefGoogle ScholarPubMed
Exner, M., Gregori, G., Pau, H. W., Vogel, F. (1985) In vivo studies on the antimicrobial activity of antiseptics on the flora of the oropharyngeal cavity. Journal of Hospital Infection 6: 185188.CrossRefGoogle ScholarPubMed
Huffman, G. G., Wood, W. H., Hausler, W. J., Jenson, J. (1974) The effects of pre-operative rinsing with cetylpyridinium chloride on bacteremia associated with the surgical removal of impacted third molars. Oral Medicine and Oral Pathology 38: 359366.CrossRefGoogle Scholar
Johnson, J. T., Myers, E. N., Sigler, B. A., Thearle, P. B., Schramm, V. L. Jr (1984) Antimicrobial prophylaxis for contaminated head and neck surgery. Laryngoscope 94: 4651.CrossRefGoogle ScholarPubMed
Johnson, J. T., Schuller, D. E., Silver, F., Gluckman, J. L., Newman, R. K., Shagets, F. W., Snyderman, N. L., Leipzig, B., Wagner, R. L. (1986) Antibiotic prophylaxis in high-risk head and neck surgery. Otolaryngology–Head and Neck Surgery 95: 554557.CrossRefGoogle ScholarPubMed
Jones, T. R., Kaulbach, H., Nichter, L., Edlich, R. F., Cantrell, R. W. (1989) Efficacy of an antibiotic mouthwash in contaminated head and neck surgery. American Journal of Surgery 158: 324327.CrossRefGoogle ScholarPubMed
Keidan, R. D., Kusiak, J. F. (1992) Complications following reconstruction with the pectoralis major myocutaneous flap. Laryngoscope 102: 521524.CrossRefGoogle ScholarPubMed
Mantravadi, R. V. P., Skolnik, E. M., Applebaum, E. L. (1981) Complications of post-operative and pre-operative radiation therapy in head and neck cancer. Archives of Otolaryngology, Head and Neck Surgery 107: 690693.CrossRefGoogle Scholar
Robbins, K. T., Favrot, S., Hanna, D., Cole, R. (1990) Risk of wound infection in patients with head and neck cancer. Head and Neck 12: 143148.CrossRefGoogle ScholarPubMed
Robinson, J. M. P. (1976) Wound infection following laryngectomy. Journal of Laryngology and Otology 90: 415425.CrossRefGoogle ScholarPubMed
Scopp, I. W., Orvieto, L. D. (1971) Gingival degerming by povidone-iodine irrigations: bacteremia reduction in extraction procedures. Journal of the American Dental Association 83: 12941296.CrossRefGoogle ScholarPubMed