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Technetium–99m(v) Dimercaptosuccinic acid planar scintigraphy in head and neck cancer: Clinical, scintigraphic and radiological study

Published online by Cambridge University Press:  29 June 2007

J. C. Watkinson ,
C. E. C. Todd ,
C. R. Lazarus ,
M. N. Maisey  and
S. E. M. Clarke
J. C. Watkinson*
Affiliation:
Departments of otolaryngology, Guy's Hospital, London. Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
C. E. C. Todd
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
C. R. Lazarus
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
M. N. Maisey
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
S. E. M. Clarke
Affiliation:
Departments of Nuclear Medicine and Radiology, Guy's Hospital, London.
*
J. C. Watkinson M.Sc, F.R.C.S., Department of Otolaryngology, Guy's Hospital, St. Thomas' Street, London SE1 9RT.
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Abstract

Technetium-99m (Tc99m)(v) Dimercaptosuccinic Acid (DMSA) is animaging agent which has been proposed as a scintigraphic marker for head and neck squamous cell carcinoma. Fifty-four patients were studied of whom 51 had a head and neck tumour. All patients were examined and then imaged using Tc99m(v) DMSA scintigraphy and computerized tomography.

Scintigraphy was less sensitive than clinical examination in the detection of patients with cancer, patients with primary tumours and patients with metastatic neck disease. CT was as sensitive and as accurate as clinical examination but more senstive than Tc99m(v) DMSA in detecting patients with cancer and with primary tumours. CT was more sensitive and more accurate than both clinical examination and Tc99m(v) DMSA scintigraphy in predicting which patients had metastatic neck disease.

Although Tc99m(v) DMSA is accumulated by squamous cell carcinoma, its inability to detect low volume disease and apparent low specificity means it has no role to play in the management of patients with head and neck squamous cell carcinoma.

Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 104 , Issue 10 , October 1990 , pp. 783 - 789
Copyright
Copyright © JLO (1984) Limited 1990

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