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Sudden hearing loss in a patient hepatitis C virus (HCV) positive on therapy with alpha-interferon: a possible autoimmune-microvascular pathogenesis

Published online by Cambridge University Press:  29 June 2007

G. Cadoni ,
L. Marinelli ,
A. De Santis ,
A. Romito ,
R. Manna  and
F. Ottaviani
G. Cadoni
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy
L. Marinelli
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy
A. De Santis
Affiliation:
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
A. Romito
Affiliation:
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
R. Manna
Affiliation:
Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy
F. Ottaviani*
Affiliation:
Institute of Otolaryngology, Catholic University of the Sacred Heart, Rome, Italy
*
Address for correspondence: Prof. Fabrizio Ottaviani, Institute of Otolaryngology, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 8, 00168 Rome, Italy Fax: +39 06 3051194
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Abstract

Alpha interferon (α-IFN) is used for the treatment of various systemic disorders. Side-effects of α-IFN therapy can involve numerous organ systems, but sudden hearing loss has only once been recorded. We report a case of sudden hearing loss occurring in a patient with chronic hepatitis C treated with α-IFN and recovered five days after the discontinuation of this agent. This is the first record of anti-endothelial cell antibodies detection in a patient with sudden hearing loss. The finding of anti-endothelial cell antibodies suggests an association between sudden hearing loss and microvascular damage during interferon therapy.

Keywords

Hearing loss, sensorineuralInterferon, alphaEndotheliumAntibody formation
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 112 , Issue 10 , October 1998 , pp. 962 - 963
Copyright
Copyright © JLO (1984) Limited 1998

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