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Sublingual immunotherapy in patients with house dust mite allergic rhinitis: prospective study of clinical outcomes over a two-year period

Published online by Cambridge University Press:  19 January 2016

J Y Soh ,
M Thalayasingam ,
S Ong ,
E X L Loo ,
L P Shek  and
S S Chao
J Y Soh
Affiliation:
University Children's Medical Institute, National University Health Systems, Singapore
M Thalayasingam
Affiliation:
Department of Paediatrics, International Medical University Clinical School, Seremban, Malaysia
S Ong
Affiliation:
Department of Otolaryngology Head and Neck Surgery, National University Health Systems, Singapore
E X L Loo
Affiliation:
Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (‘A*STAR’), Singapore
L P Shek*
Affiliation:
University Children's Medical Institute, National University Health Systems, Singapore
S S Chao
Affiliation:
Department of Otolaryngology Head and Neck Surgery, National University Health Systems, Singapore
*
Address for correspondence: Dr Lynette Pei-Chi Shek, NUHS Tower Block, Level 12, 1E Kent Ridge Road, Singapore119228 E-mail: [email protected]
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Abstract

Background:

Sublingual immunotherapy in patients with allergic rhinitis sensitised to house dust mites is safe, but its efficacy is controversial and sublingual immunotherapy with Blomia tropicalis has not yet been studied. This study sought to evaluate the efficacy of sublingual immunotherapy with house dust mite extract in children and adults with house dust mite allergic rhinitis over a period of two years.

Methods:

A prospective observational study was conducted of children and adults diagnosed with house dust mite allergic rhinitis who were treated with sublingual immunotherapy from 2008 to 2012. Total Nasal Symptom Scores, Mini Rhinoconjunctivitis Quality of Life scores and medication usage scores were assessed prospectively.

Results:

Thirty-nine patients, comprising 24 children and 15 adults, were studied. Total Nasal Symptom Scores and Mini Rhinoconjunctivitis Quality of Life scores dropped significantly at three months into therapy, and continued to improve. Medication usage scores improved at one year into immunotherapy.

Conclusion:

Sublingual immunotherapy with house dust mite extracts, including B tropicalis, is efficacious as a treatment for patients with house dust mite allergic rhinitis.

Keywords

Sublingual ImmunotherapyRhinitis, AllergicDust Mites, House
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 3 , March 2016 , pp. 272 - 277
Copyright
Copyright © JLO (1984) Limited 2016 

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