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Serum matrix metalloproteinases and tympanosclerosis

Published online by Cambridge University Press:  19 October 2010

H Aslan ,
M Sinan Başoğlu ,
B Şentürk ,
C Özbay ,
H Katilmiş  and
S Öztürkcan
H Aslan*
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
M Sinan Başoğlu
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
B Şentürk
Affiliation:
Department of Biochemistry, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
C Özbay
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
H Katilmiş
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
S Öztürkcan
Affiliation:
Department of Otorhinolaryngology and Head and Neck Surgery, Atatürk Research and Training Hospital, Ministry of Health, İzmir, Turkey
*
Address for correspondence: Op Dr Hale Aslan, Kasırga Sok 22/1, Özyıldırım Sitesi B blok K:8 D:18, Balçova, İzmir, Turkey Fax: +90 232 2431530 E-mail: [email protected]
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Abstract

Aim:

To investigate levels of matrix metalloproteinases 2 and 9, and of their tissue inhibitor (i.e. tissue inhibitor matrix metalloproteinase 1), in the serum of patients with tympanosclerosis.

Materials and method:

We included 40 patients (age range 13–63 years) who had undergone surgery in the ENT department of İzmir Atatürk Training and Research Hospital between 2002 and 2007. Twenty had uncomplicated chronic otitis media and 20 had tympanosclerosis. We also included as the control group 20 individuals with no history of previous otic complaints or systemic or infectious disease. Serum levels of serum matrix metalloproteinases 2 and 9 and of tissue inhibitor matrix metalloproteinase 1 were measured in all subjects and compared.

Result:

Significantly higher levels of serum matrix metalloproteinases 2 and 9 were found in the tympanosclerosis group, compared with the chronic otitis media and control groups. There was no statistically significant difference in tissue inhibitor matrix metalloproteinase 1 level between the three groups.

Conclusion:

Tympanosclerosis surgery has poor success rates, since the pathological process is still active. We suggest that high levels of matrix metalloproteinases may play a role in the continuation of the disease process.

Keywords

TympanosclerosisEtiologySerumMatrix Metalloproteinase
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 2 , February 2011 , pp. 142 - 146
Copyright
Copyright © JLO (1984) Limited 2010

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