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Serum antibodies against respiratory tract viruses in episodes of acute otitis media

Published online by Cambridge University Press:  29 June 2007

Göran Harsten ,
Karin Prellner ,
Bengt Löfgren  and
Olof Kalm
Göran Harsten*
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Karin Prellner
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
Bengt Löfgren
Affiliation:
Departments of Oto-Rhino-Laryngology and Medical Microbiology, University Hospital, Lund, Sweden.
Olof Kalm
Affiliation:
Departments of Oto-Rhino-Laryngology, University Hospital, Lund, Sweden.
*
Göran Harsten, M.D., Ph.D., Department of Oto-Rhino-Laryngology, University Hospital, S-221 85 Lund, Sweden.
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Abstract

Although the findings of epidemiological studies have suggested viral respiratory tract infection (RTI) to be crucially involved in the development of acute otitis media (AOM), the relationship between AOM and viral RTI remains unclear. Serum samples, obtained in the acute and convalescent phases of 57 AOM episodes (in 35 children during the first three years of life) were analysed for IgG antibodies against influenza A viruses, influenza B viruses, parainfluenza virus type 1, respiratory syncytial virus and adenoviruses.

One third of the AOM episodes (18/57) could be related to viral RTI, as evidenced by significant increases in viral serum antibody activity. Treatment failure occurred in four AOM episodes where increases in serum viral antibody activity were noted. In three of these failures, antibiotic treatment was unsuccessful despite the bacterial strains not being resistant to the drug used. This suggests that concomitant viral infection may be a determinant of treatment outcome in some AOM episodes.

Keywords

Otitis media, acuteAntibodiesVirus, respiratory tract
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 5 , May 1991 , pp. 337 - 340
Copyright
Copyright © JLO (1984) Limited 1991

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