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Salvage surgery following irradiation with different fractionation regimes in the treatment of carcinoma of the laryngo pharynx: experience gained from a British Institute of Radiology Study

Published online by Cambridge University Press:  29 June 2007

C. J. Alcock ,
J. F. Fowler ,
J. L. Haybittle ,
J. W. Hopewell ,
M. Rezvani  and
G. Wiernik
C. J. Alcock
Affiliation:
Department of Radiotherapy & Oncology, The Churchill Hospital, Headington, Oxford OX3 7LJ, UK.
J. F. Fowler
Affiliation:
Human Oncology, K4/336, 600 Highland Avenue, Madison, W153792, U.S.A.
J. L. Haybittle
Affiliation:
M.R.C. Cancer Trials Office. 7 Green Street, Cambridge, CB2 3JU, U.K.
J. W. Hopewell
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
M. Rezvani
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
G. Wiernik
Affiliation:
Research Institute (University of Oxford), The Churchill Hospital, Headington, Oxford, OX3 7LJ, U.K.
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Abstract

The 10-year follow-up of patients in a clinical trial involving the comparison of treatment by three fractions per week versus five fractions per week in radiotherapy of squamous carcinoma of the larynx and hypopharynx has now been completed. The trial involved an intake of 734 patients between 1966 and 1975. No statistically significant differences have been found between the two trial arms in terms of overall survival, age corrected survival, local recurrence, laryngectomy-free rates or effects on the normal tissues. Local recurrence was found in 320 of the 713 evaluable patients (45 per cent). Salvage laryngectomy was performed in 151 of the 320 patients with recurrence (47 per cent). Survival at 10 years for all node negative patients was 50 per cent in those patients without primary recurrence, compared with 40 per cent in those undergoing salvage laryngectomy.

Keywords

Laryngeal neoplasmsRadiotherapyLaryngectomy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 106 , Issue 2 , February 1992 , pp. 147 - 153
Copyright
Copyright © JLO (1984) Limited 1992

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References

British Institute of Radiology Working Party (1990) Final report of the general clinical results of the British Institute of Radiology Fractionation Study of 3f/week versus 5f/week. Radiotherapy of the Laryngo-pharynx, 63: 169–180.Google Scholar
Dobbs, J., Barrett, A. (1985) Larynx. In Practical Radiotherapy Planning. Edward Arnold (Publishers) Ltd.: London, p. 21.Google Scholar
Groves, J., Gray, R. F. (1985). In A Synopsis of Otolaryngology. Wright: Bristol, p. 399.Google Scholar
Henk, J. M, Whittam, D. E. (1982) Ear, Nose and Throat. In Treatment of Cancer. Chapman & Hall Ltd.: London, p. 236.Google Scholar
Mantel, N. (1966) Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemotherapy Reports, 5: 163–170.Google Scholar
Million, R. R., Cassisi, N. J., Wittes, R. E. (1982). Cancer in the Head and Neck. In Cancer Principles and Practice of Oncology. J. P. Lippincott Company, Philadelphia, Toronto, p. 361.Google Scholar
Preliminary Report of the Working Party of the British Institute of Radiology on the Effects of Dose Fractionation in Radiotherapy (1963) British Journal of Radiology, 36: 382–383.CrossRefGoogle Scholar
Rezvani, M., Alcock, C. J., Fowler, J. B., Haybittle, J. L., Hopewell, J. W., Wiernik, G. (1989) A comparison of the normal tissue reactions in patients treated with either 3F/week or 5F/week in the BIR Trial of Radiotherapy for Carcinoma of the Laryngopharynx. International Journal of Radiation Biology, 56: 717–720.Google Scholar
Robin, P. E., Olofsson, J. (1987) Chapter title. In Scott-Brown's Otolaryngology, Fifth Edition, Vol. 5, Laryngology (Stell, P. M. and Kerr, A. G., eds.) Butterworths: London, Boston.Google Scholar
Souhami, R. L., Tobias, J. S. (1986). Cancer of the Head and Neck. In Cancer and its Management. Blackwell Scientific Publications: Oxford, p. 156.Google Scholar
U.L.C.C. (1968) TNM Classification of malignant tumours. First edition. (International Union Against Cancer, Geneva).Google Scholar
U.I.C.C. (1974) TNM Classification of Malignant Tumours, Second edn., (International Union Against Cancer, Geneva).Google Scholar
U.I.C.C. (1978) TNM Classification of Malignant Tumours, Third edn., (International Union Against Cancer, Geneva).Google Scholar
U.I.C.C. (1987) TNM Classification of Malignant Tumours, Fourth edn., International Union Against Cancer (Springer-Verlag, London).Google Scholar