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Salvage brachytherapy and salvage surgery for recurrent oropharyngeal carcinoma following radiotherapy

Published online by Cambridge University Press:  29 June 2007

Carlos A. Regueiro ,
Alejandro de la Torre ,
Francisco J. Valcárcel ,
Rosa MagallóN  and
Gregorio Aragón
Carlos A. Regueiro*
Affiliation:
Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
Alejandro de la Torre
Affiliation:
Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
Francisco J. Valcárcel
Affiliation:
Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
Rosa MagallóN
Affiliation:
Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
Gregorio Aragón
Affiliation:
Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
*
Address for correspondence: Carlos A. Regueiro, Ph.D., Department of Radiation Oncology, Clínica Puerta de Hierro, San Martin de Porres 4, 28035 Madrid, Spain.
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Abstract

We reviewed 21 patients who underwent salvage treatment after a biopsy of proven locally recurrent carcinoma of the oropharynx. Two of these patients underwent a second salvage treatment after failure of the first. Treatment was performed with Ir192 interstitial implant in 17 cases (13 rT1 and 4 rT2); by surgery in five cases (3 rT1, 1 rT2, 1 rTx), including two patients who had relapsed after salvage treatment with Ir192 implant; and by hyperfractionated external beam irradiation plus concomitant Tegafur chemotherapy in one case (rT3).

The primary tumour was controlled in four of the 17 cases (23 percent) treated with Ir192 implant. Of these four patients, two remained disease-free 42 and 59 months after treatment, one died of nodal metastases eight months after treatment and another of distant metastases 19 months after treatment. Four of the five cases (80 per cent) treated with surgery, including two patients who relapsed after salvage brachytherapy, remained free from local, regional and distant relapse 21, 25, 31 and 56 months after treatment.

Keywords

Oropharyngeal neoplasmsCarcinomaBrachytherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 109 , Issue 1 , January 1995 , pp. 45 - 48
Copyright
Copyright © JLO (1984) Limited 1995

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