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Safe application of mitomycin C within the nasal cavity

Published online by Cambridge University Press:  07 January 2011

T Gutierrez  and
C Hopkins
T Gutierrez*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK
C Hopkins
Affiliation:
Department of Otolaryngology, Head and Neck Surgery, Guy's and St Thomas' NHS Foundation Trust, London, UK
*
Address for correspondence: Ms Tatiana Gutierrez, Guy's and St Thomas’ NHS Trust, Great Maze Pond, London SE1 9RT, UK E-mail: [email protected]
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Abstract

Objective:

To describe a novel technique of delivering mitomycin C safely via endoscopic sinus surgery.

Case report:

Mitomycin C was applied in the median frontal drainage pathway of a 44-year-old woman suffering from recalcitrant chronic frontal sinusitis. The mitomycin C was soaked onto a neurosurgical patty, which was delivered through a nasopharyngeal tube trimmed to ensure delivery directly to the desired area, thus sparing adjacent mucosa.

Conclusions:

Mitomycin C has been suggested to have a useful role in reducing post-operative scarring after endonasal surgery. The long term safety of topical mitomycin C is not yet known, and inadvertent topical application to adjacent mucosa should be avoided. The described technique achieves this in a simple manner, and can be easily applied to other locations.

Keywords

Frontal SinusMitomycin CEndoscopic SurgeryComplications
Type
Short Communications
Information
The Journal of Laryngology & Otology , Volume 125 , Issue 3 , March 2011 , pp. 309 - 310
Copyright
Copyright © JLO (1984) Limited 2010

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References

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3Heran, M, Baird, R, Blair, G, Skarsgard, E. Topical mitomycin C for recalcitrant esophageal strictures: a novel endoscopic/fluoroscopic technique for safe endoluminal delivery. J Pediatr Surg 2008;43:815–18CrossRefGoogle ScholarPubMed