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The role of platelet-rich plasma in microlaryngeal surgery: a randomised, controlled trial

Published online by Cambridge University Press:  10 February 2022

A Gaafar Open the ORCID record for A Gaafar [Opens in a new window] ,
A Eldeghiedy ,
R ElMaghraby ,
I Nouh  and
M Donia
A Gaafar*
Affiliation:
Department of Otolaryngology, Head and Neck Surgery Unit, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
A Eldeghiedy
Affiliation:
Clinical Pathology, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
R ElMaghraby
Affiliation:
Department of Otolaryngology, Phoniatrics Unit, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
I Nouh
Affiliation:
Department of Otolaryngology, Head and Neck Surgery Unit, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
M Donia
Affiliation:
Department of Otolaryngology, Head and Neck Surgery Unit, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
*
Author for correspondence: Dr A Gaafar, Department of Otolaryngology, Head and Neck Surgery Unit, Faculty of Medicine, Alexandria University, Champollion Street, Alexandria21131, Egypt E-mail: [email protected]
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Abstract

Objective

Platelet-rich plasma has gained interest over the two last decades, mainly because of its role in regenerative medicine. This work aimed to assess the role of intra-operative local application of platelet-rich plasma gel in the improvement of quality of voice after microlaryngeal surgery.

Method

This was a prospective comparative study that included 40 patients undergoing microlaryngeal surgery for benign vocal fold lesions. There were two groups divided equally into study group A and control group B. The assessment of voice was performed by videostroboscopy and acoustic analysis pre-operatively and at two weeks and one and three months post-operatively.

Results

The data demonstrated that all the stroboscopic and acoustic parameters showed significant improvement in both groups. Group A showed significant improvement regarding acoustic parameters at the third post-operative follow up when compared with group B.

Conclusion

Platelet-rich plasma has a beneficial effect on voice quality following microlaryngeal surgery based in particular on acoustic parameters.

Keywords

Vocal CordsPlatelet-Rich PlasmaVoice Quality
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 8 , August 2022 , pp. 737 - 741
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr A Gaafar takes responsibility for the integrity of the content of the paper

References

Zhang, Z. Cause-effect relationship between vocal fold physiology and voice production in a three-dimensional phonation model. J Acoust Soc Am 2016;139:149310.1121/1.4944754CrossRefGoogle Scholar
Cohen, SM, Dupont, WD, Courey, MS. Quality-of-life impact of non-neoplastic voice disorders: a meta-analysis. Ann Otol Rhinol Laryngol 2006;115:128–3410.1177/000348940611500209CrossRefGoogle ScholarPubMed
Mortensen, M. Laryngeal steroid injection for vocal fold scar. Curr Opin Otolaryngol Head Neck Surg 2010;18:487–9110.1097/MOO.0b013e32833fe112CrossRefGoogle ScholarPubMed
Gonzalez-Herranz, R, Amarillo, E, Hernandez-Garcia, E, Montojo Woodeson, J, Plaza-Mayor, G. Amplitude of glottal mucosal wave after vocal fold microflap with or without fibrin glue. J Voice 2017;31:342–610.1016/j.jvoice.2016.07.013CrossRefGoogle ScholarPubMed
Morisaki, T, Kishimoto, Y, Tateya, I, Kawai, Y, Suzuki, R, Tsuji, T et al. Adipose-derived mesenchymal stromal cells prevented rat vocal fold scarring. Laryngoscope 2018;128:33–4010.1002/lary.26855CrossRefGoogle ScholarPubMed
Padilla, S, Orive, G, Sanchez, M, Anitua, E, Hsu, WK. Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. J Am Acad Orthop Surg 2014;22:469–70Google ScholarPubMed
Stavrakas, M, Karkos, PD, Markou, K, Grigoriadis, N. Platelet-rich plasma in otolaryngology. J Laryngol Otol 2016;130:1098–10210.1017/S0022215116009403CrossRefGoogle ScholarPubMed
Marques, LF, Stessuk, T, Camargo, IC, Sabeh Junior, N, dos Santos, L, Ribeiro-Paes, JT. Platelet-rich plasma (PRP): methodological aspects and clinical applications. Platelets 2015;26:101–1310.3109/09537104.2014.881991CrossRefGoogle ScholarPubMed
Drago, L, Bortolin, M, Vassena, C, Romano, CL, Taschieri, S, Del Fabbro, M. Plasma components and platelet activation are essential for the antimicrobial properties of autologous platelet-rich plasma: an in vitro study. PLoS One 2014;9:e10781310.1371/journal.pone.0107813CrossRefGoogle Scholar
Marx, RE. Platelet-rich plasma: evidence to support its use. J Oral Maxillofac Surg 2004;62:489–9610.1016/j.joms.2003.12.003CrossRefGoogle ScholarPubMed
Pomerantz, J, Dutton, JM. Platelet gel for endoscopic sinus surgery. Ann Otol Rhinol Laryngol 2005;114:699–70410.1177/000348940511400908CrossRefGoogle ScholarPubMed
Pavlovic, V, Ciric, M, Jovanovic, V, Stojanovic, P. Platelet rich plasma: a short overview of certain bioactive components. Open Med (Wars) 2016;11:242–710.1515/med-2016-0048CrossRefGoogle Scholar
Anitua, E, Prado, R, Padilla, S, Orive, G. Platelet-rich plasma therapy: another appealing technology for regenerative medicine? Regen Med 2016;11:355–7CrossRefGoogle ScholarPubMed
Cobden, SB, Ozturk, K, Duman, S, Esen, H, Aktan, TM, Avunduk, MC et al. Treatment of acute vocal fold injury with platelet-rich plasma. J Voice 2016;30:731–510.1016/j.jvoice.2015.07.012CrossRefGoogle ScholarPubMed
Woo, SH, Jeong, HS, Kim, JP, Koh, EH, Lee, SU, Jin, SM et al. Favorable vocal fold wound healing induced by platelet-rich plasma injection. Clin Exp Otorhinolaryngol 2014;7:47–5210.3342/ceo.2014.7.1.47CrossRefGoogle ScholarPubMed
Mobarsa, V, Samdani, SK, Gurjar, VS. Outcome analysis of microlaryngeal surgery for benign lesions of vocal cord using videostroboscopy and voice handicap index. Indian J Otolaryngol Head Neck Surg 2019;71:327–3210.1007/s12070-018-1300-0CrossRefGoogle ScholarPubMed
Shiotani, A, Fukuda, H, Kawaida, M, Kanzaki, J. Vocal fold vibration in simulated head voice phonation in excised canine larynges. Eur Arch Otorhinolaryngol 1996;253:356–6310.1007/BF00178292CrossRefGoogle ScholarPubMed
Gray, SD, Pignatari, SS, Harding, P. Morphologic ultrastructure of anchoring fibers in normal vocal fold basement membrane zone. J Voice 1994;8:48–5210.1016/S0892-1997(05)80318-2CrossRefGoogle ScholarPubMed
Kim, T, Kim, S, Park, J, No, S, Jin, S, Lee, S, eds. Efficacy and safety of vocal cord platelet-rich plasma (PRP) injection in patient with intractable vocal cord disease. Proceedings of the KSLP Conference. Seoul: The Korean Society of Logopedics and Phoniatrics, 2017Google Scholar