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Rhinocerebral mucormycosis: Use of liposomal amphotericin B

Published online by Cambridge University Press:  29 June 2007

Edward W. Fisher ,
Abbad Toma ,
Phillip H. Fisher  and
Anthony D. Cheesman
Edward W. Fisher*
Affiliation:
London
Abbad Toma
Affiliation:
London
Phillip H. Fisher
Affiliation:
London
Anthony D. Cheesman
Affiliation:
London
*
E. W. Fisher, M.A., F.R.C.S., The Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, London WC1X 8DA.
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Abstract

Rhinocerebral mucormycosis is a rare but often fatal condition characterized by an aggressive necrotizing infection spreading from the nose to the paranasal sinuses, orbit and hence to the central nervous system. A case is reported in which a diabetic male with advanced mucormycosis was successfully treated by a combination of surgery, supportive therapy and liposomal amphotericin B. Liposomal delivery allows the drug to be both less toxic and more effective, and this is the first reported case of its use in rhinocerebral mucormycosis.

Keywords

MucormycosisAmphotericin B
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 105 , Issue 7 , July 1991 , pp. 575 - 577
Copyright
Copyright © JLO (1984) Limited 1991

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