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The relationship between lung function and the clinical and histopathological features in Chinese patients with nasal polyps

Published online by Cambridge University Press:  15 August 2017

Q L Zhao ,
L Yu ,
L L Zhi ,
P Jin ,
X X Zi ,
L Zhao ,
A Li ,
Y Y Tu ,
L Shi  and
H P Zhang
Q L Zhao
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China Department of Otolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong, China
L Yu
Affiliation:
Department of Otolaryngology, Jinan Central Hospital Affiliated to Shandong University, Shandong, China
L L Zhi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China Department of Otolaryngology, Central Hospital of Zibo, Shandong, China
P Jin
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
X X Zi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
L Zhao
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
A Li
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
Y Y Tu
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
L Shi
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
H P Zhang*
Affiliation:
Department of Otolaryngology, The Second Hospital of Shandong University, Shandong, China
*
Address for correspondence: Dr Hong Ping Zhang, Department of Otolaryngology, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong 250033, PR China Fax: +86 531 8896 2544 E-mail: [email protected]
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Abstract

Objective:

To investigate lung function in Chinese patients suffering from chronic rhinosinusitis with nasal polyps and examine its association with histopathological features.

Methods:

The lung function of 99 patients with nasal polyps was measured. Haematoxylin and eosin and immunohistochemistry staining were performed to evaluate any inflammatory cells and epithelial tissue remodelling.

Results:

Predicted maximal expiratory flow rate at 25 per cent vital capacity was reduced (p < 0.05) in epithelial hyperplasia, and predicted maximal expiratory flow rate at 50 per cent vital capacity was reduced (p < 0.05) in goblet cell hyperplasia. Both peripheral blood eosinophilia and tissue eosinophilia nasal polyps manifested significantly reduced: forced expiratory volume in 1 second/forced vital capacity ratio, predicted maximal expiratory flow rate at 25, 50 and 75 per cent of vital capacity, and predicted maximal mid-expiratory flow. Peripheral blood eosinophils were negatively correlated with predicted maximal expiratory flow rate at 25 and 50 per cent of vital capacity, and predicted maximal mid-expiratory flow. Eosinophils in tissue were negatively correlated with all lung function parameters investigated except predicted forced vital capacity.

Conclusion:

Clinicians should be aware of lung function decline in nasal polyps patients, especially in those with tissue eosinophilia.

Keywords

Nasal PolypsRespiratory Function TestsAirway RemodelingEosinophilsChinese
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 131 , Issue 10 , October 2017 , pp. 880 - 888
Copyright
Copyright © JLO (1984) Limited 2017 

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