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Regenerative medicine in the upper aerodigestive tract, temporal bone dissection, nasal douching and management changes at The Journal of Laryngology & Otology

Published online by Cambridge University Press:  14 June 2021

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Abstract

Type
Editorial
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

The twentieth century saw great advances in the diagnosis and treatment of head and neck cancer. Green and colleaguesReference Green, Shubber, Koumpa and Hamilton1 from London and Leeds (UK) remind us in their article in this issue that ‘… despite relatively high cure rates and survival, treatment with surgical excision, chemotherapy or radiotherapy results in tissue loss and fibrosis within the upper aerodigestive tract. Severe long-term disability may ensue …’. One strategy to help patients is regenerative medicine. This includes cell transplantation, the injection of bioactive factors, scaffolds and bioengineering of laryngeal structures. We published a paper on this topic in 2015,Reference Wormald, Fishman, Juniat, Tolley and Birchall2 which is updated by more recent studies cited in this month's article. The authors advise that research and development should focus on pathologies in which there is a high disease burden in the patient population. They conclude: ‘Regenerative techniques may decrease operating time, eliminate the need of a donor site, improve healing and improve quality of life outcomes’.

Training and skill acquisition in temporal bone surgery is close to the heart of all otologists. There have been numerous challenges facing teachers and students in recent years, such as a lack of organs donated for teaching, and the UK organ-retention scandal and its legal repercussions. One such challenge has been the difficulties in supply and use of human temporal bones, which has been the topic of previous papers in The Journal of Laryngology & Otology,Reference Jeannon3Reference George and De6 and ideas such as plastic bones or three-dimensional (3D) printed bones have been considered.Reference Da Cruz and Francis7 Having acquired a means of practising temporal bone dissection, how do we determine that the trainee has enough skill to safely move from the temporal bone laboratory to the real patient? This issue includes a paper by Stavrakos and colleagues from Thessaloniki, Greece,Reference Stavrakos, Menexes, Triaridis, Bamidis, Constantinidis and Karkos8 which uses 3D-printed bones and applies the principles of objective structured assessment of technical skill (‘OSATS’). This involved two assessors evaluating videos of the dissection, and answering seven questions and one overall question on the performance. The results suggested that the method was reliable and valid. This type of assessment seems labour-intensive for an ENT department, which will involve staff time that requires funding, but it seems to be a fair way of determining when a trainee is fit to transfer safely from the laboratory to the patient and so satisfy the demands of regulators and the public.

The ever-popular topic of nasal irrigation has two contributions in this month's issue of The Journal. Turfe and colleagues from various US centresReference Turfe, Zhao, Palmer and Craig9 describe how fluid dynamics modelling can show the efficacy of douching on reaching the maxillary sinus in standard antrostomy versus more extensive endoscopic medial maxillectomy in recalcitrant maxillary sinus disease. The latter allowed faster and more forceful coverage of the sinus, although both methods produced complete coverage, which is perhaps unsurprising. Ocak and colleagues from Ankara, Turkey, compare a douche with surfactant versus one with sodium hyaluronate, and compared mucociliary clearance in both.Reference Ocak, Mulazimoglu, Kocaoz, Mirici, Dagli and Acar10 They found that both methods were superior to saline, and similar to one another. The general topic of nasal douching was covered in recent years in an article in The Journal from Guangzhou, China.Reference Chen, Feng, Chang, Lai, Chen and Li11

This month sees the retirement of our long-serving Managing Editor, Rosamund Greensted, and the arrival of our new Managing Editor, Catherine Hyland. Both have had distinguished careers before joining The Journal. We thank Rosamund for her enormous contribution to The Journal since 2004. Rosamund's efforts have encompassed tasks and guidance that go well beyond the requirement of her formal role, and we all will miss her both personally and professionally. We wish Rosamund every happiness in her retirement and welcome Catherine warmly to The Journal family.

References

Green, FR, Shubber, NM, Koumpa, FS, Hamilton, NJI. Regenerative medicine for end-stage fibrosis and tissue loss in the upper aerodigestive tract: a twenty-first century review. J Laryngol Otol 2021;135:473–85CrossRefGoogle ScholarPubMed
Wormald, JC, Fishman, JM, Juniat, S, Tolley, N, Birchall, MA. Regenerative medicine in otorhinolaryngology. J Laryngol Otol 2015;129:732–9CrossRefGoogle ScholarPubMed
Jeannon, J-P. Temporal bones for dissection: a diminishing asset? J Laryngol Otol 1996;110:219–20CrossRefGoogle ScholarPubMed
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Morris, DP, Benbow, EW, Ramsden, RT. ‘Bones of contention’. The donation of temporal bones for dissection after the organ-retention scandals. J Laryngol Otol 2001;115:689–93CrossRefGoogle Scholar
George, AP, De, R. Review of temporal bone dissection: how it was, is and will be. J Laryngol Otol 2010;124:119–25CrossRefGoogle Scholar
Da Cruz, MJ, Francis, HW. Face and content validation of a novel three-dimensional printed temporal bone for surgical skills development. J Laryngol Otol 2015;129:S23–9CrossRefGoogle ScholarPubMed
Stavrakos, M, Menexes, G, Triaridis, S, Bamidis, P, Constantinidis, J, Karkos, PD. Objective structured assessment of technical skill in temporal bone dissection: validation of a novel tool. J Laryngol Otol 2021;135:518–28CrossRefGoogle Scholar
Turfe, Z, Zhao, K, Palmer, JN, Craig, JR. Computational fluid dynamic modelling of maxillary sinus irrigation after maxillary antrostomy and modified endoscopic medial maxillectomy. J Laryngol Otol 2021;135:555–9CrossRefGoogle ScholarPubMed
Ocak, E, Mulazimoglu, S, Kocaoz, D, Mirici, E, Dagli, E, Acar, A. Effect of adjunctive sodium hyaluronate versus surfactant nasal irrigation on mucociliary clearance in allergic rhinitis: a single-blind, randomised, controlled study. J Laryngol Otol 2021;135:529–32CrossRefGoogle ScholarPubMed
Chen, XZ, Feng, SV, Chang, LH, Lai, XP, Chen, XH, Li, X et al. The effects of nasal irrigation with various solutions after endoscopic sinus surgery: systematic review and meta-analysis. J Laryngol Otol 2018;132:673–9CrossRefGoogle ScholarPubMed