Hostname: page-component-586b7cd67f-rdxmf Total loading time: 0 Render date: 2024-11-26T13:52:29.727Z Has data issue: false hasContentIssue false
  • English
  • Français

Primary composite squamous cell carcinoma and large cell neuroendocrine carcinoma of the hypopharynx

Published online by Cambridge University Press:  29 June 2007

C. M. Milroy ,
P. J. Robinson  and
H. R. Grant
C. M. Milroy*
Affiliation:
Department of Histopathology, University College and Middlesex School of Medicine
P. J. Robinson
Affiliation:
Department of Otolaryngology, University College Hospital, London.
H. R. Grant
Affiliation:
Department of Otolaryngology, University College Hospital, London.
*
Dr C. M. Milroy, Department of Histopathology, University College and Middlesex School of Medicine, Rockefeller Building, University Street, London WC1E 6JJ
Get access Rights & Permissions [Opens in a new window]

Abstract

Neuroendocrine carcinomas are rare neoplasms of the larynx and hypopharynx. Tumours composed of both neuroendocrine and Squamous cell elements are very rare. We report a case of a primary hypopharyngeal carcinoma composed of both squamous cell and large cell neuroendocrine carcinoma and discuss the treatment of this patient and management of neuroendocrine carcinomas of the larynx and hypopharynx.

Type
View from beneath — Pathology in Focus
Information
The Journal of Laryngology & Otology , Volume 103 , Issue 11 , November 1989 , pp. 1093 - 1096
Copyright
Copyright © JLO (1984) Limited 1989

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Baugh, R. F., Wolf, G. T., Lloyd, R. V., McClatchey, K. D. and Evans, D. A. (1987) Carcinoid (neuroendocrine carcinoma) of the larynx. Annals of Otology, Rhinology and Laryngology, 96: 315–321.CrossRefGoogle ScholarPubMed
Chen, D. A., Mandell-Brown, M., Moore, S. F. and Johnson, J. T. (1986) ‘Composite tumour—mixed squamous cell and small-cell anaplastic carcinoma of the larynx. Otolaryngology—Head and Neck Surgery, 95: 99–103.Google Scholar
Ferlito, A. (1976a) Histological classification of larynx and hypopharynx cancers and their clinical implications. Pathologic aspects of 2,052 malignant neoplasms diagnosed at the ORL department of Padua University from 1966 to 1976. Acta Otolaryngologica, Supplement 342: 1–88.Google Scholar
Ferlito, A. (1976b) Adenosquamous carcinoma of the larynx. A clinical and pathologic study. Report of four cases and review of the literature. Acta Oto-rhino-laryngologica Belgica, 30: 379–389.Google Scholar
Ferlito, A. (1980) Double primary synchronous and metachronous cancer of the larynx and hypopharynx with dissimilar histology. Archives of Oto-Rhino-Laryngology, 229: 107–119.Google Scholar
Ferlito, A. and Polidoro, F. (1980) Simultaneous primary oat cell carcinoma (Apudoma) and squamous cell carcinoma of the hypopharynx. ORL: Journal of Oto-Rhino-Laryngology and its related specialties. 42: 146–157.Google Scholar
Ferlito, A., Friedmann, I. and Goldman, N. C. (1988) Primary carcinoid tumour of the larynx. ORL: Journal for Oto-Rhino-Laryngology and its related specialties, 50: 129–149.Google Scholar
Gerughty, R. M., Henninger, G. R. and Brown, F. M. (1968) Adenosquamous carcinoma of the nasal, oral and laryngeal cavities. A clinicopatholgic survey of ten cases. Cancer, 22: 1140–1155.3.0.CO;2-1>CrossRefGoogle Scholar
Giddings, N. A., Kennedy, T. L. and Vrabec, D. P. (1987) Primary small cell carcinoma of the larynx: analysis of treatment. Journal of Otolaryngology, 16: 157–166.Google Scholar
Glossop, L. P., Griffiths, M. and Grant, H. R. (1984) Combined adenocarcinoma and squamous carcinoma of the hypopharynx. A case report. Journal of Laryngology and Otology, 98: 1161–1166.Google Scholar
Gnepp, D. R., Ferlito, A. and Hyams, V. (1983) Primary small cell (oat cell) carcinoma of the larynx: Review of the literature and report of 18 cases. Cancer, 51: 1731–1745.Google Scholar
Goldman, N. C., Hood, I. and Singleton, G. T. (1969) Carcinoid of the larynx. Archives of Otolaryngology, 90: 91–93.Google ScholarPubMed
Ibrahim, N. B. N., Briggs, J. C. and Corbishley, C. M. (1984) Extrapulmonary oat cell carcinoma. Cancer, 54: 1645–1661.3.0.CO;2-Q>CrossRefGoogle ScholarPubMed
McDowell, E. M. and Trump, B. J. (1981) Pulmonary small cell carcinoma showing tripartite differentiation in individual cells. Human Pathology, 12: 286–294.CrossRefGoogle ScholarPubMed
McDowell, E. M., Wilson, T. S. and Trump, B. F. (1981) Atypical endocrine tumours of the lung. Archives of Pathology and Laboratory Medicine, 105: 20–28.Google Scholar
McSweeny, E. C., McDonnell, L. and O'Brien, C. (1981) Medullary carcinoma of the thyroid presenting as tumours of the pharynx and larynx. Histopathology, 5: 263–275.Google Scholar
Mills, S. E., Cooper, P. H., Garland, T. A. and Johns, M. E. (1983) Small cell undifferentiated carcinoma of the larynx. Cancer, 51: 116–120.Google Scholar
Palvio, H. P., Sørensen, F. P. and Kløve-Morgensen, M. (1985) Stem cell carcinoma of the colon and rectum. Report of two cases and review of the literature. Diseases of the Colon and Rectum, 28: 440–445.Google Scholar
Porto, D. P., Wick, M. R., Ewing, S. L. and Adams, G. L. (1987) Neuroendocrine carcinoma of the larynx. American Journal of Otolaryngology, 9: 97–104.Google Scholar
Sniege, N., Mackay, B., Ordenez, N. G., Batsakis, J. G. (1983) Laryngeal paraganglioma. Archives of Otolaryngology, 109: 113–117.Google Scholar
Stanley, R. J., DeSanto, L. W., Weiland, L. H. (1986) Oncocytic and oncocytoid tumours (well differentiated neuroendocrine carcinomas) of the larynx. Archives of Otolaryngology, 112: 529–535.CrossRefGoogle ScholarPubMed
Wain, S. L., Kier, R., Vollmer, R. T., Bossen, E. H. (1986) Basaloid-squamous carcinoma of the tongue, hypopharynx and larynx. Human Pathology, 17: 1158–1166.CrossRefGoogle ScholarPubMed
Wenig, B. M., Hyams, V. J. and Heffner, D. K. (1988) Moderately differentiated neuroendocrine carcinoma of the larynx. Cancer, 62: 2658–2676.3.0.CO;2-M>CrossRefGoogle ScholarPubMed
Woodruff, J. M., Huvos, A. G., Erlandson, R. A., Shah, J. P., Gerold, F. P. (1985) Neuroendocrine carcinomas of the larynx. A study of two histological types, one of which mimics thyroid medullary carcinoma. American Journal of Surgical Pathology, 9: 771–790.Google Scholar