Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-26T12:23:51.607Z Has data issue: false hasContentIssue false
  • English
  • Français

Prevalence and aetiology of profound deafness in the general population of Sichuan, China

Published online by Cambridge University Press:  29 June 2007

Xuezhong Liu ,
Lirong Xu ,
Silig Zhang  and
Yin Xu
Xuezhong Liu*
Affiliation:
Department of Otolaryngology, West China University of Medical Sciences, Chengdu, China
Lirong Xu
Affiliation:
Department of Otolaryngology, West China University of Medical Sciences, Chengdu, China
Silig Zhang
Affiliation:
Department of Epidemiological Survey, Sichuan Family Planning Research institute, Chengdu, China
Yin Xu
Affiliation:
Department of Epidemiological Survey, Sichuan Family Planning Research institute, Chengdu, China
*
Dr Xuezhong Liu, Centre for Audiology, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Get access Rights & Permissions [Opens in a new window]

Abstract

People with profound deafness were surveyed in the general population of Sichuan. The results showed that the overall prevalence in Sichuan was 0.186 per cent (236/126 876) of the general population, males 0.2 12 per cent (135/63 741), females 0.159 per cent (101/63 135) (p 0.05). Two hundred and fifteen (92 per cent) cases were older than 10 years, but 227 (96 per cent) lost their hearing under the age of 10 years, 192 (80 per cent) under five years, and 104 (44 per entwere congenital). There was no significant difference in prevalence of deafness between the population located in urban and rural areas. However, the population living in the flat area and mountain area had a much higher prevalence than that of the hill people (p 0.05). Amongst the nationalities investigated, there existed significant differences in prevalence. Both the population of the Hui and the Lisu presented a significantly higher prevalence of profound deafness than that of the others. In aetiology, genetic factors may account for 43 per cent (101/236) of the cases, amongst which, autosomal recessive (AR) deafness is 92 per cent (95/104) and autosomal dominant (AD) 5.4 per cent. Environmental factors were thought to be responsible for 35.6 per cent (84/236) of cases, including infectious diseases (31 per cent), ototoxic antibiotics (2.6 per cent), injury (1.7 per cent), and asphyxia (0.4 per cent). The number of cases of unknown origin were 20.3 per cent. It is suggested that, in China, the importance of genetic factors in hearing impairment should be emphasized. In addition, infectious diseases and ototoxicity play an important role in causing deafness.

Keywords

DeafnessprofoundPrevalenceaetiology
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 107 , Issue 11 , November 1993 , pp. 990 - 993
Copyright
Copyright © JLO (1984) Limited 1993

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Davis, A. C. (1983). Hearing in the Population: First Phase Findings of the MRC National Study of Hearing, Academic Press, IAC, London. pp 35–58.Google Scholar
Finley, D. J. (1949) The truncated binomial distribution. Annals of Eugenics 14: 319–328.CrossRefGoogle Scholar
Fraser, G. R. (1976). The Causes of Profound Deafness in Children, John Hopkins University Press, Baltimore. pp 24–34.Google Scholar
Hu, D. N., Qiu, W. Q., Wu, B. T., Fang, L. Z., Zhou, F., Gu, Y. P., Zhang, Q. H., Yan, J. H. (1987) Prevalence and genetic aspects of deaf mutism in Shanghai. Journal of Medical Genetics 24: 589–592.Google Scholar
Jiang, S. Z., Wang, S. L., Liu, P. I. (1988) The survey of hearing loss in Nangton County, China. Chinese Journal of Otolaryngology 23: 282–283.Google Scholar
Konigsmark, B. W., Gorlin, R. J. (1976). Genetic and Metabolic Deafness, W. B. Saunders, Philadelphia. pp 24–50.Google Scholar
Liu, X. Z., Xu, L. R. (1988) Sensorineural hearing loss: a segregation analysis. Chinese Journal of Medical Genetics 5: 193–195.Google Scholar
Newton, V. F. (1985) Aetiology of bilateral sensorineural hearing loss in young children. Journal of Laryngology and Otology 99 Supplement: pp 10–29.Google Scholar
Vogel, F., Motulsky, A. G. (1979). Human Genetic Problems and Approaches. Springer-Verlag, New York, Appendix 3.Google Scholar
Williamson, I., Steel, K. (1991) The aetiology of hearing impairment. Hereditary Deafness Newsletter 7: 7–16.Google Scholar
Zhang, S. L., Tang, X. D., Zhang, S. Z. (1990). Genetico-Epidemiological Survey of the General Population in Sichuan, C.S.T. University Press, Chengdu, pp 10–58.Google Scholar