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Presbylarynx: is diabetes mellitus a risk factor for vocal atrophy? A prospective case–control study

Published online by Cambridge University Press:  25 November 2021

M Santos ,
A Machado ,
S Vaz Freitas ,
C Almeida e Sousa  and
Á Moreira da Silva
M Santos*
Affiliation:
Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar (‘ICBAS’), Universidade do Porto, Porto, Portugal
A Machado
Affiliation:
Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar (‘ICBAS’), Universidade do Porto, Porto, Portugal
S Vaz Freitas
Affiliation:
Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar (‘ICBAS’), Universidade do Porto, Porto, Portugal Faculty of Health Sciences, Universidade Fernando Pessoa, Porto, Portugal Laboratory of Artificial Intelligence and Decision Support (‘LIAAD’), Institute for Systems and Computer Engineering, Technology and Science (‘INESC TEC’), Porto, Portugal
C Almeida e Sousa
Affiliation:
Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar (‘ICBAS’), Universidade do Porto, Porto, Portugal
Á Moreira da Silva
Affiliation:
Centro Hospitalar Universitário do Porto, Institute of Biomedical Sciences Abel Salazar (‘ICBAS’), Universidade do Porto, Porto, Portugal
*
Author for correspondence: Dr Mariline Santos, Largo Abel Salazar, Centro Hospitalar Universitário do Porto, Portugal E-mail: [email protected]
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Abstract

Objective

To evaluate the prevalence of diabetes mellitus type 2 in subjects with presbylarynx.

Method

A case–control, prospective study was carried out on consecutive subjects who presented to the otorhinolaryngology department.

Results

The study comprised 174 subjects (60 males and 114 females) with a mean age of 73.99 years (65–95 years). Presbylarynx was identified in 71 patients (41 per cent). Among patients with diabetes mellitus type 2, 20 patients (77 per cent) exhibited endoscopic signs of presbylarynx. A statistically significant difference was found between presbylarynx versus no presbylarynx concerning diabetes mellitus type 2 (p < 0.001). Subjects with diabetes mellitus type 2 were approximately eight times more likely to have presbylarynx compared to subjects without diabetes mellitus type 2.

Conclusion

In this study, 77 per cent of patients with diabetes mellitus type 2 had endoscopic signs of presbylarynx. A multivariable analysis, which took into account co-morbidities of the elderly, identified diabetes mellitus type 2 as a possible risk factor for presbylarynx. Many physiopathological mechanisms might explain this result, as diabetes mellitus type 2 is known to affect muscular, neurological and vascular systems.

Keywords

LarynxAtrophyDiabetes Mellitus
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 9 , September 2022 , pp. 871 - 874
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr M Santos takes responsibility for the integrity of the content of the paper

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