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Post-operative radiotherapy in advanced laryngeal cancer: effect on local and regional recurrence, distant metastases and second primaries

Published online by Cambridge University Press:  08 March 2006

Taner Yılmaz ,
Şefik Hoşal ,
Enis Özyar ,
Fadıl Akyol  and
Bülent Gürsel
Taner Yılmaz
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Şefik Hoşal
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Enis Özyar
Affiliation:
Department of Radiation Oncology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Fadıl Akyol
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
Bülent Gürsel
Affiliation:
Department of Otolaryngology-Head & Neck Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
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Abstract

This was a retrospective study of patients who did or did not receive post-operative radiotherapy for squamous cell carcinoma of the larynx.

The rates of local and regional recurrences, distant metastases and second primaries were evaluated in 236 patients who received radiotherapy following surgery. These rates were evaluated and compared with those from 294 patients treated with surgery alone.

Multivariate analysis of irradiated patients revealed that local and regional recurrences were determined independently by tumour (T) and pathologic node (pN) stages (p < 0.05). The distant metastasis rate significantly depended on N stage (p < 0.05). Multiple primary tumours were not significantly affected by any of the factors studied (p > 0.05).

Analysis of both irradiated and non-irradiated patients revealed that local and regional recurrence was determined independently by pathologic T (pT) stage, tumour localization, radiation status and pN stages (p < 0.05). The distant metastasis rate significantly depended on N stage and tumour localization (p < 0.05) and the rate of formation of multiple primary tumours was significantly affected by the patient's age and radiation status (p < 0.05).

In conclusion irradiation of laryngeal cancer patients independently increases the risk of local and regional recurrence, and also increases the risk of multiple primary tumours while not significantly influencing the risk of distant metastasis. The risk of distant metastasis is affected by determinants of advanced lesions and tumour localization.

Keywords

Head and Neck NeoplasmsNeoplasm MetastasisRadiotherapyRisk Factors
Type
Research Article
Information
The Journal of Laryngology & Otology , Volume 119 , Issue 10 , October 2005 , pp. 784 - 790
Copyright
© 2005 Royal Society of Medicine Press

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