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Outcomes of surgical versus non-surgical treatment of resectable T4a laryngeal and hypopharyngeal carcinoma

Published online by Cambridge University Press:  18 March 2022

S Thiagarajan Open the ORCID record for S Thiagarajan [Opens in a new window] ,
M Gupta ,
P Sathe ,
G Gill ,
S Ghosh-Laskar Open the ORCID record for S Ghosh-Laskar [Opens in a new window] ,
K Prabhash  and
D Chaukar
S Thiagarajan*
Affiliation:
Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
M Gupta
Affiliation:
Department of Surgical Oncology, HealthCare Global, Ranchi, Jharkhand, India
P Sathe
Affiliation:
Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
G Gill
Affiliation:
Department of ENT, Kothari Hospital, Bikaner, India
S Ghosh-Laskar
Affiliation:
Department of Radiation Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
K Prabhash
Affiliation:
Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
D Chaukar
Affiliation:
Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, India
*
Author for correspondence: Dr S Thiagarajan, Department of Head and Neck Surgical Oncology, Tata Memorial Hospital, Parel, Mumbai400012, India E-mail: [email protected]
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Abstract

Objective

Surgery is the recommended treatment for resectable T4a laryngeal and hypopharyngeal carcinoma. Non-surgical treatment is an option in a select few patients.

Method

This retrospective study was undertaken to assess the treatment outcomes in patients with resectable T4a carcinoma of the larynx and hypopharynx who received either surgical or non-surgical treatment at our institute and to assess factors influencing these outcomes.

Results

A total of 120 patients were included in the study. They were divided into groups A, B and C based on the presence of extralaryngeal spread through laryngeal membrane, cartilage or both. The overall survival was better among patients who received surgery than those who received non-surgical treatment in the three groups. The factor influencing overall survival was the treatment given in the form of surgical versus non-surgical treatment.

Conclusion

Surgery is the preferred treatment for T4a laryngeal and hypopharyngeal carcinoma, even in patients with extralaryngeal spread without cartilage erosion.

Keywords

Carcinoma LarynxCarcinoma HypopharynxT4aTreatment Pattern
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 136 , Issue 11 , November 2022 , pp. 1087 - 1095
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Dr S Thiagarajan takes responsibility for the integrity of the content of the paper

Presented at the Foundation of Head and Neck Oncology 2020 virtual meeting, 12–13 December 2020.

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