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Osteoclastic activity in chronic otitis media with cholesteatoma-related bone destruction

Published online by Cambridge University Press:  05 August 2021

A Özgür ,
T Yemiş ,
E Başbulut ,
N F Turgut ,
D Özdemir ,
G Akgül ,
D M Mehel  and
M Çelebi
A Özgür*
Affiliation:
İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital, Department of Otorhinolaryngology, İstanbul, Turkey
T Yemiş
Affiliation:
Department of Otorhinolaryngology, Gümüşhane State Hospital, Gümüşhane/Turkey
E Başbulut
Affiliation:
Microbiology Laboratory, Samsun Education and Research Hospital, Samsun/Turkey
N F Turgut
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
D Özdemir
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
G Akgül
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
D M Mehel
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
M Çelebi
Affiliation:
Department of Otorhinolaryngology, Samsun Health Practices and Research Centre, University of Health Sciences, Samsun, Turkey
*
Author for correspondence: Dr Abdulkadir Özgür, İstanbul Yeni Yüzyıl University Gaziosmanpaşa Hospital Merkez Mah. Cukurcesme Caddesi No: 51 PB: 34245, Gaziosmanpaşa, İstanbul, Turkey E-mail: [email protected]
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Abstract

Background

Cholesteatoma-related bone destruction is the cause of many complications due to chronic otitis media. This study aimed to evaluate osteoclastic activity in cholesteatoma-related bone destruction using tartrate-resistant acid phosphatase 5b, an enzyme specific to osteoclastic activity.

Method

Seventy-two patients diagnosed with chronic otitis media were included in this study and were divided into two groups: with and without bone destruction. The blood serum and tissue tartrate-resistant acid phosphatase 5b levels from both groups were compared.

Results

There were no significant differences in the level of serum enzymes between both groups. However, in tissue samples, tartrate-resistant acid phosphatase 5b levels were significantly lower in the bone destruction group than the group without bone destruction.

Conclusion

This study determined that the level of tartrate-resistant acid phosphatase 5b, a specific enzyme for osteoclastic activity in cholesteatoma-related bone destruction, is locally decreased. This data suggests that osteoclastic activity may decrease in cholesteatoma-related bone destruction. However, further experimental and clinical studies are required to clarify this highly complex mechanism.

Keywords

CholesteatomaBone DestructionChronic Otitis Media
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 135 , Issue 10 , October 2021 , pp. 879 - 882
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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Footnotes

Dr A Özgür takes responsibility for the integrity of the content of the paper

References

Kuo, CL, Liao, WH, Shiao, AS. A review of current progress in acquired cholesteatoma management. Eur Arch Otorhinolaryngol 2015;272:3601–910.1007/s00405-014-3291-0CrossRefGoogle ScholarPubMed
Olszewska, E, Wagner, M, Bernal-Sprekelsen, M, Ebmeyer, J, Dazert, S, Hildmann, H et al. Etiopathogenesis of cholesteatoma. Eur Arch Otorhinolaryngol 2004;261:6–24CrossRefGoogle ScholarPubMed
Hamed, MA, Nakata, S, Sayed, RH, Ueda, H, Badawy, BS, Nishimura, Y et al. Pathogenesis and bone resorption in acquired cholesteatoma: current knowledge and future prospectives. Clin Exp Otorhinolaryngol 2016;9:298–308CrossRefGoogle ScholarPubMed
Xie, S, Wang, X, Ren, J, Liu, W. The role of bone resorption in the etiopathogenesis of acquired middle ear cholesteatoma. Eur Arch Otorhinolaryngol 2017;274:2071–8CrossRefGoogle ScholarPubMed
Jeong, JH, Park, CW, Tae, K, Lee, SH, Shin, DH, Kim, KR et al. Expression of RANKL and OPG in middle ear cholesteatoma tissue. Laryngoscope 2006;116:1180–410.1097/01.mlg.0000224345.59291.daCrossRefGoogle ScholarPubMed
Imai, R, Sato, T, Iwamoto, Y, Hanada, Y, Terao, M, Ohta, Y et al. Osteoclasts modulate bone erosion in cholesteatoma via RANKL signaling. J Assoc Res Otolaryngol 2019;20:449–59CrossRefGoogle ScholarPubMed
Koizumi, H, Suzuki, H, Ikezaki, S, Ohbuchi, T, Hashida, K, Sakai, A. Osteoclasts are not activated in middle ear cholesteatoma. J Bone Miner Metab 2016;34:193–200CrossRefGoogle Scholar
Koizumi, H, Suzuki, H, Kawaguchi, R, Hashida, K, Hohchi, N, Ohkubo, JI et al. Presence of osteoclasts in middle ear cholesteatoma: a study of undecalcified bone sections. Acta Otolaryngol 2017;137:127–30CrossRefGoogle ScholarPubMed
Yemis, T, Ozgur, A, Basbulut, E, Ozdemir, D, Akgul, G, Mehel, DM et al. Bone turnover in chronic otitis media with bone destruction. Eur Arch Otorhinolaryngol 2020;277:2229–33CrossRefGoogle ScholarPubMed
Oddie, GW, Schenk, G, Angel, NZ, Walsh, N, Guddat, LW, de Jersey, J et al. Structure, function, and regulation of tartrate-resistant acid phosphatase. Bone 2000;27:575–8410.1016/S8756-3282(00)00368-9CrossRefGoogle ScholarPubMed
Rissanen, JP, Suominen, MI, Peng, Z, Halleen, JM. Secreted tartrate-resistant acid phosphatase 5b is a marker of osteoclast number in human osteoclast cultures and the rat ovariectomy model. Calcif Tissue Int 2008;82:108–1510.1007/s00223-007-9091-4CrossRefGoogle ScholarPubMed
Lyubimova, NV, Pashkov, MV, Tyulyandin, SA, Gol'dberg, VE, Kushlinskii, NE. Tartrate-resistant acid phosphatase as a marker of bone metastases in patients with breast cancer and prostate cancer. Bull Exp Biol Med 2004;138:77–9CrossRefGoogle ScholarPubMed
Reithmeier, A, Norgard, M, Ek-Rylander, B, Nareoja, T, Andersson, G. Cathepsin K regulates localization and secretion of tartrate-resistant acid phosphatase (TRAP) in TRAP-overexpressing MDA-MB-231 breast cancer cells. BMC Mol Cell Biol 2020;21:15CrossRefGoogle Scholar
Lv, Y, Wang, G, Xu, W, Tao, P, Lv, X, Wang, Y. Tartrate-resistant acid phosphatase 5b is a marker of osteoclast number and volume in RAW 264.7 cells treated with receptor-activated nuclear kappaB ligand. Exp Ther Med 2015;9:143–6CrossRefGoogle ScholarPubMed
Mira-Pascual, L, Patlaka, C, Desai, S, Paulie, S, Nareoja, T, Lang, P et al. A novel sandwich ELISA for tartrate-resistant acid phosphatase 5a and 5b protein reveals that both isoforms are secreted by differentiating osteoclasts and correlate to the type i collagen degradation marker CTX-I in vivo and in vitro. Calcif Tissue Int 2020;106:194–207CrossRefGoogle ScholarPubMed
Hamzei, M, Ventriglia, G, Hagnia, M, Antonopolous, A, Bernal-Sprekelsen, M, Dazert, S et al. Osteoclast stimulating and differentiating factors in human cholesteatoma. Laryngoscope 2003;113:436–42CrossRefGoogle ScholarPubMed
Capeller, B, Caffier, H, Sutterlin, MW, Dietl, J. Evaluation of tartrate-resistant acid phosphatase (TRAP) 5b as serum marker of bone metastases in human breast cancer. Anticancer Res 2003;23:1011–15Google ScholarPubMed
Tauchert, S, di Liberto, A, Cordes, T, Thill, M, Salehin, D, Friedrich, M. Tartrate-resistant acid phosphatase (TRAP) as a serum marker for bone resorption in breast cancer patients with bone metastases. Clin Exp Obstet Gynecol 2009;36:219–25Google ScholarPubMed
Chole, RA. Osteoclasts in chronic otitis media, cholesteatoma, and otosclerosis. Ann Otol Rhinol Laryngol 1988;97:661–6CrossRefGoogle ScholarPubMed
Xie, S, Pan, Z, Yin, T, Ren, J, Liu, W. Expression of PTHrP and RANKL in acquired middle ear cholesteatoma epithelium. Acta Otolaryngol 2020;140:351–510.1080/00016489.2020.1717609CrossRefGoogle ScholarPubMed
Walsh, MC, Choi, Y. Biology of the RANKL-RANK-OPG system in immunity, bone, and beyond. Front Immunol 2014;5:511CrossRefGoogle ScholarPubMed