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Oral squamous cell carcinoma in human immunodeficiency virus positive patients: clinicopathological audit

Published online by Cambridge University Press:  14 December 2011

F M A Butt ,
M L Chindia  and
F Rana
F M A Butt*
Affiliation:
Department of Human Anatomy, University of Nairobi, Kenya
M L Chindia
Affiliation:
Department of Oral and Maxillofacial Surgery, University of Nairobi, Kenya
F Rana
Affiliation:
Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya
*
Address for correspondence: Dr F M A Butt, P O Box 25361, Code 00603, Nairobi, Kenya Fax: +254 20 2710712 E-mail: [email protected]
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Abstract

Background:

Most human immunodeficiency virus positive patients now have a longer life expectancy, with the advent of highly active antiretroviral therapy. However, they are now at increased risk of developing a malignancy during their lives.

Aim:

To investigate the age at which oral squamous cell carcinoma presents in patients infected with human immunodeficiency virus.

Study design:

Prospective, clinicohistopathological audit of patients infected with human immunodeficiency virus.

Results:

Of 200 human immunodeficiency virus positive patients, 16 (8 per cent) presented with oral squamous cell carcinoma (nine women and seven men; age range 18–43 years, mean age 31.7 years). The majority of patients (62.5 per cent) had stage III and IV disease (tumour-node-metastasis staging). There was a predilection for poorly differentiated oral squamous cell carcinoma (using Broder's histopathological classification).

Conclusion:

Oral squamous cell carcinoma associated with human immunodeficiency virus infection appears to present at a relatively young age.

Keywords

Oral CavityCarcinoma, Squamous CellEpidemiologyHuman Immunodeficiency Virus
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 126 , Issue 3 , March 2012 , pp. 276 - 278
Copyright
Copyright © JLO (1984) Limited 2011

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