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Olfactory neural tumours—the role of external beam radiotherapy

Published online by Cambridge University Press:  29 June 2007

N. J. Slevin ,
C. J. R. Irwin ,
S. S. Banerjee ,
N. K. Gupta  and
W. T. Farrington
N. J. Slevin*
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
C. J. R. Irwin
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
S. S. Banerjee
Affiliation:
Department of Pathology, Christie Hospital, Manchester, UK
N. K. Gupta
Affiliation:
Department of Radiotherapy, Christie Hospital, Manchester, UK
W. T. Farrington
Affiliation:
Department of Surgery, Christie Hospital, Manchester, UK
*
Address for correspondence: Dr N. J. Slevin, Consultant Radiotherapist and Oncologist, Christie Hospital NHS Trust, Wilmslow Road, Withington, Manchester M20 4BX Fax: 0161-446-3352
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Abstract

Olfactory neuroblastoma is an uncommon tumour arising in the nasal cavity or paranasal sinuses. We report the management of nine cases treated with external beam radiotherapy subsequent to sureery, either attempted definitive removal or biopsy only. Recent refinements in pathologicalevaluation of these tumours are discussed. Seven cases were deemed classical olfactory neuroblastoma whilst two were classified as neuroendocrine carcinoma. The clinical features, radirap technique and variable natural history are presented. Seven of eight patients treatecall were controlled locally, with a minimumfollow-up of two years. Three patients developedcervica lymph node disease and three patients died of systemic metastatic disease. Suggestios are made as to which patients should have en-bloc resection rather than definitive radiotherapy.

Keywords

NeuroblastomaOlfactory nerveRadiotherapy
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 110 , Issue 11 , November 1996 , pp. 1012 - 1016
Copyright
Copyright © JLO (1984) Limited 1996

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